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Gene Review

JMJD6  -  jumonji domain containing 6

Homo sapiens

Synonyms: Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, Histone arginine demethylase JMJD6, JmjC domain-containing protein 6, Jumonji domain-containing protein 6, KIAA0585, ...
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Disease relevance of JMJD6


Psychiatry related information on JMJD6

  • At follow-up, patients participated in a 4 to 6 hour interview that assessed current and lifetime Axis I disorders (SCID-I), current Axis II disorders (PDE), eating behaviors (EAT, BSQ, EDI, PSR), global functioning (GAF), social adjustment (SAS-SR), and treatment and medical problems experienced since discharge [5].
  • This paper reports on turnover intentions of PSR workers, a rapidly growing sector of the community mental health labor force as reported in a nationwide survey [6].
  • The present study examined the relationship between the perception by homosexual males of positive or negative societal reaction to homosexuality (PSR), their degree of conformity to heterosexual norms, and their degree of psychological adjustment [7].

High impact information on JMJD6


Chemical compound and disease context of JMJD6

  • Combinations of inhibitory and subinhibitory concentrations of thienamycin with 55 vol% of defibrinated human blood resulted in additive effects against all PSR and NSS test strains of S. marcescens and against the NSS Escherichia coli control strain ATCC 25922 [11].
  • Although hypoxia (fractional concentration of O2 in air = 0.06) had no significant effect on fictive breathing, ventilating frogs with increasing CO2 levels (fractional CO2 concentration in inspired air range: 0.00-0.03) increased the number of breaths in each fictive breathing episode, and this effect was potentiated by PSR feedback [12].
  • We concluded: (i) [15N]glycine cannot be used to measure the PSR in patients with evidence of liver disease; the results are best interpreted in terms of glycine metabolism; (ii) the "apparent" PSR correlated with clinical status; and (iii) an elevated PSR in a patient with a malignancy is not necessarily due to protein metabolism by the tumor [13].

Biological context of JMJD6

  • Recently, a putative phosphatidylserine receptor (PSR) was identified and proposed to mediate recognition of phosphatidylserine and phagocytosis [14].
  • Apoptosis was detected by the TUNEL method, and the RNA protection assay (RPA) was used to compare activation of apoptosis with PSR mRNA expression levels [2].
  • Up-regulation of PSR could be confirmed by Western blot analysis [2].
  • The RNA protection assay revealed high mRNA levels of the antiapoptotic genes bcl-2 and bfl-1 (P < 0.05) in chronic pancreatitis tissues with high PSR mRNA expression [2].
  • Genetic deficiency of PSR in the mouse is lethal perinatally, and results to date have been ambiguous with regard to the phagocytic and inflammatory phenotypes associated with that deficiency [15].

Anatomical context of JMJD6

  • These results allowed us to conclude that SR-BI is a phagocytosis-inducing PS receptor of Sertoli cells [16].
  • The phosphatidylserine receptor is expressed on the surface of macrophages and is crucial for the recognition and engulfment of apoptotic cells [2].
  • A newly described phosphatidylserine receptor, critical in the phagocytosis of apoptotic cells by macrophages, is also expressed at similar levels on human microglia [17].
  • Our results suggest that both PSR and SR-B1 are expressed in nursing TECs and these receptors appear to play a major role in the clearance of apoptotic cells from the thymus [18].
  • We conclude that PET can be used to estimate skeletal muscle PSR in healthy human subjects and that it holds promise for future in vivo, noninvasive studies of the influences of physiological factors, pharmacological manipulations, and disease states on this important component of muscle protein turnover and balance [19].

Associations of JMJD6 with chemical compounds


Other interactions of JMJD6


Analytical, diagnostic and therapeutic context of JMJD6

  • METHODS: The expression and localization of PSR were analyzed by Northern blot analysis, RT-PCR, Western blot analysis and immunohistochemistry [2].
  • Indeed, affinity-purified anti-PSR antibodies identified a 47 kDa protein species in cells transfected with untagged PSR and localized this protein in the nuclei by immunofluorescent confocal microscopy [3].
  • Ligation of PSR by PS on AC surfaces is considered essential for signaling uptake of ACs that are tethered to phagocytes via other receptors [26].
  • Positron emission tomography (PET) with L-[methyl-11C]methionine was explored as an in vivo, noninvasive, quantitative method for measuring the protein synthesis rate (PSR) in paraspinal and hind limb muscles of anesthetized dogs [20].
  • For quantification of the protein synthesis rate (PSR), arterial cannulation with repeated blood sampling to obtain the plasma input function and a dynamic TYR PET study to calculate a time-activity curve are necessary [27].


  1. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. Vandivier, R.W., Fadok, V.A., Hoffmann, P.R., Bratton, D.L., Penvari, C., Brown, K.K., Brain, J.D., Accurso, F.J., Henson, P.M. J. Clin. Invest. (2002) [Pubmed]
  2. Phosphatidylserine receptor in chronic pancreatitis: evidence for a macrophage independent role. Köninger, J., Balaz, P., Wagner, M., Shi, X., Cima, I., Zimmermann, A., di Sebastiano, P., Büchler, M.W., Friess, H. Ann. Surg. (2005) [Pubmed]
  3. Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals. Cui, P., Qin, B., Liu, N., Pan, G., Pei, D. Exp. Cell Res. (2004) [Pubmed]
  4. Brain tumors: L-[1-C-11]tyrosine PET for visualization and quantification of protein synthesis rate. Pruim, J., Willemsen, A.T., Molenaar, W.M., van Waarde, A., Paans, A.M., Heesters, M.A., Go, K.G., Visser, G.M., Franssen, E.J., Vaalburg, W. Radiology. (1995) [Pubmed]
  5. Outcome and clinical course in inpatient bulimic women: a 2- to 9-year follow-up study. Fallon, B.A., Walsh, B.T., Sadik, C., Saoud, J.B., Lukasik, V. The Journal of clinical psychiatry. (1991) [Pubmed]
  6. Turnover intentions of community mental health workers in psychosocial rehabilitation services. Blankertz, L.E., Robinson, S.E. Community mental health journal. (1997) [Pubmed]
  7. The relationship of perceived societal hostility, conformity, and psychological adjustment in homosexual males. Ross, M.W. Journal of homosexuality. (1978) [Pubmed]
  8. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Fadok, V.A., Bratton, D.L., Rose, D.M., Pearson, A., Ezekewitz, R.A., Henson, P.M. Nature (2000) [Pubmed]
  9. Phosphatidylserine recognition by phagocytes: a view to a kill. Wu, Y., Tibrewal, N., Birge, R.B. Trends Cell Biol. (2006) [Pubmed]
  10. Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells. Hoffmann, P.R., deCathelineau, A.M., Ogden, C.A., Leverrier, Y., Bratton, D.L., Daleke, D.L., Ridley, A.J., Fadok, V.A., Henson, P.M. J. Cell Biol. (2001) [Pubmed]
  11. Interactions of antimicrobial drugs and combined phagocytic/serum bactericidal activity of defibrinated human blood against Serratia marcescens. IV. N-formimidoyl thienamycin. Traub, W.H. Chemotherapy. (1983) [Pubmed]
  12. Role of pulmonary stretch receptor feedback in control of episodic breathing in the bullfrog. Kinkead, R., Milsom, W.K. Am. J. Physiol. (1997) [Pubmed]
  13. Whole-body protein turnover in metabolically stressed patients and patients with cancer as measured with [15N] glycine. Stein, T.P., Ang, S.D., Schluter, M.D., Leskiw, M.J., Nusbaum, M. Biochemical medicine. (1983) [Pubmed]
  14. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Wang, X., Wu, Y.C., Fadok, V.A., Lee, M.C., Gengyo-Ando, K., Cheng, L.C., Ledwich, D., Hsu, P.K., Chen, J.Y., Chou, B.K., Henson, P., Mitani, S., Xue, D. Science (2003) [Pubmed]
  15. The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells. Mitchell, J.E., Cvetanovic, M., Tibrewal, N., Patel, V., Colamonici, O.R., Li, M.O., Flavell, R.A., Levine, J.S., Birge, R.B., Ucker, D.S. J. Biol. Chem. (2006) [Pubmed]
  16. Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular sertoli cells. Kawasaki, Y., Nakagawa, A., Nagaosa, K., Shiratsuchi, A., Nakanishi, Y. J. Biol. Chem. (2002) [Pubmed]
  17. Phagocytosis of apoptotic inflammatory cells by microglia and its therapeutic implications: termination of CNS autoimmune inflammation and modulation by interferon-beta. Chan, A., Seguin, R., Magnus, T., Papadimitriou, C., Toyka, K.V., Antel, J.P., Gold, R. Glia (2003) [Pubmed]
  18. Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells. Cao, W.M., Murao, K., Imachi, H., Hiramine, C., Abe, H., Yu, X., Dobashi, H., Wong, N.C., Takahara, J., Ishida, T. J. Mol. Endocrinol. (2004) [Pubmed]
  19. Muscle protein synthesis by positron-emission tomography with L-[methyl-11C]methionine in adult humans. Fischman, A.J., Yu, Y.M., Livni, E., Babich, J.W., Young, V.R., Alpert, N.M., Tompkins, R.G. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  20. Measurement of muscle protein synthesis by positron emission tomography with L-[methyl-11C]methionine. Hsu, H., Yu, Y.M., Babich, J.W., Burke, J.F., Livni, E., Tompkins, R.G., Young, V.R., Alpert, N.M., Fischman, A.J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  21. Human alveolar epithelial cells engulf apoptotic eosinophils by means of integrin- and phosphatidylserine receptor-dependent mechanisms: a process upregulated by dexamethasone. Sexton, D.W., Blaylock, M.G., Walsh, G.M. J. Allergy Clin. Immunol. (2001) [Pubmed]
  22. Selection and slippage creating serine homopolymers. Huntley, M.A., Golding, G.B. Mol. Biol. Evol. (2006) [Pubmed]
  23. Fourteen-member macrolides promote the phosphatidylserine receptor-dependent phagocytosis of apoptotic neutrophils by alveolar macrophages. Yamaryo, T., Oishi, K., Yoshimine, H., Tsuchihashi, Y., Matsushima, K., Nagatake, T. Antimicrob. Agents Chemother. (2003) [Pubmed]
  24. CD14-dependent clearance of apoptotic cells by human macrophages: the role of phosphatidylserine. Devitt, A., Pierce, S., Oldreive, C., Shingler, W.H., Gregory, C.D. Cell Death Differ. (2003) [Pubmed]
  25. Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. Fadok, V.A., Savill, J.S., Haslett, C., Bratton, D.L., Doherty, D.E., Campbell, P.A., Henson, P.M. J. Immunol. (1992) [Pubmed]
  26. Tethering and tickling: a new role for the phosphatidylserine receptor. Somersan, S., Bhardwaj, N. J. Cell Biol. (2001) [Pubmed]
  27. L-1-11C-tyrosine PET in patients with laryngeal carcinomas: comparison of standardized uptake value and protein synthesis rate. de Boer, J.R., Pruim, J., van der Laan, B.F., Que, T.H., Willemsen, A.T., Albers, F.W., Vaalburg, W. J. Nucl. Med. (2003) [Pubmed]
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