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Chemical Compound Review

NSC-308875     2-[2- [[(3R,8S,10R,12S,13R,17R)- 3,12...

Synonyms: AC1L73CT, NCI60_002645, Ginsenoside Rg1 mixture with ginsenoside A1
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Disease relevance of NSC308875

  • In the present study, we describe that ginsenoside-Rg1 (G-Rg1) stimulates the proliferation of cultured human hepatoma SK-HEP-1 cells [1].

High impact information on NSC308875


Biological context of NSC308875


Anatomical context of NSC308875


Gene context of NSC308875


Analytical, diagnostic and therapeutic context of NSC308875


  1. Ginsenoside-Rg1 positively regulates cyclin E-dependent kinase activity in human hepatoma SK-HEP-1 cells. Lee, K.Y., Lee, S.K. Biochem. Mol. Biol. Int. (1996) [Pubmed]
  2. Ginsenoside-Rg1 Induces Vascular Endothelial Growth Factor Expression through the Glucocorticoid Receptor-related Phosphatidylinositol 3-Kinase/Akt and beta-Catenin/T-cell Factor-dependent Pathway in Human Endothelial Cells. Leung, K.W., Pon, Y.L., Wong, R.N., Wong, A.S. J. Biol. Chem. (2006) [Pubmed]
  3. Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells. Leung, K.W., Cheng, Y.K., Mak, N.K., Chan, K.K., Fan, T.P., Wong, R.N. FEBS Lett. (2006) [Pubmed]
  4. Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor. Lee, Y.J., Chung, E., Lee, K.Y., Lee, Y.H., Huh, B., Lee, S.K. Mol. Cell. Endocrinol. (1997) [Pubmed]
  5. Ginsenoside-Rg1 regulates the induction of tyrosine aminotransferase gene transcription in rat hepatocyte cultures. Kang, S.Y., Lee, K.Y., Lee, S.K. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  6. Effect of ginseng saponins on the survival of cerebral cortex neurons in cell cultures. Himi, T., Saito, H., Nishiyama, N. Chem. Pharm. Bull. (1989) [Pubmed]
  7. Inductive effect of ginsenoside-Rg1 on tyrosine aminotransferase gene expression in rat primary hepatocyte cultures. Kim, M.Y., Lee, K.Y., Lee, S.K. Biochem. Mol. Biol. Int. (1994) [Pubmed]
  8. Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. IV. Decomposition of ginsenoside-Rg1 and -Rb1 in the digestive tract of rats. Odani, T., Tanizawa, H., Takino, Y. Chem. Pharm. Bull. (1983) [Pubmed]
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