Gene Review:
NR3C1 - nuclear receptor subfamily 3, group C,...
Homo sapiens
Synonyms:
GCCR, GCR, GCRST, GR, GRL, ...
Chang,
Powles,
Allred,
Ashley,
Clark,
Makris,
Assersohn,
Gregory,
Osborne,
Dowsett,
Okamoto,
Isohashi,
Koyano,
Saito,
Sai,
Kurose,
Ozawa,
Nakajima,
Matsumoto,
Saito,
Shirao,
Yoshida,
Minami,
Ohtsu,
Saijo,
Sawada,
Korte,
Cuzzocrea,
Bruscoli,
Crisafulli,
Mazzon,
Agostini,
Mui??,
Esposito,
Di Virgilio,
Meli,
Vegeto,
Maggi,
Riccardi,
Webster,
Tonelli,
Sternberg,
Binder,
Salyakina,
Lichtner,
Wochnik,
Ising,
Pütz,
Papiol,
Seaman,
Lucae,
Kohli,
Nickel,
Künzel,
Fuchs,
Majer,
Pfennig,
Kern,
Brunner,
Modell,
Baghai,
Deiml,
Zill,
Bondy,
Rupprecht,
Messer,
Köhnlein,
Dabitz,
Brückl,
Müller,
Pfister,
Lieb,
Mueller,
Lõhmussaar,
Strom,
Bettecken,
Meitinger,
Uhr,
Rein,
Holsboer,
Muller-Myhsok,
Zarate,
Singh,
Manji,
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- Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2. Sengupta, S., Wasylyk, B. Genes Dev. (2001)
- Biologic markers as predictors of clinical outcome from systemic therapy for primary operable breast cancer. Chang, J., Powles, T.J., Allred, D.C., Ashley, S.E., Clark, G.M., Makris, A., Assersohn, L., Gregory, R.K., Osborne, C.K., Dowsett, M. J. Clin. Oncol. (1999)
- Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. Assenat, E., Gerbal-Chaloin, S., Larrey, D., Saric, J., Fabre, J.M., Maurel, P., Vilarem, M.J., Pascussi, J.M. Hepatology (2004)
- Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. Wu, W., Pew, T., Zou, M., Pang, D., Conzen, S.D. J. Biol. Chem. (2005)
- Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness. Perlman, W.R., Webster, M.J., Kleinman, J.E., Weickert, C.S. Biol. Psychiatry (2004)
- Corticosteroids in relation to fear, anxiety and psychopathology. Korte, S.M. Neuroscience and biobehavioral reviews. (2001)
- Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer's disease. Seckl, J.R., French, K.L., O'Donnell, D., Meaney, M.J., Nair, N.P., Yates, C.M., Fink, G. Brain Res. Mol. Brain Res. (1993)
- Cellular plasticity cascades: targets for the development of novel therapeutics for bipolar disorder. Zarate, C.A., Singh, J., Manji, H.K. Biol. Psychiatry (2006)
- Neuroendocrine regulation of immunity. Webster, J.I., Tonelli, L., Sternberg, E.M. Annu. Rev. Immunol. (2002)
- Glucocorticoids in T cell development and function*. Ashwell, J.D., Lu, F.W., Vacchio, M.S. Annu. Rev. Immunol. (2000)
- Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Binder, E.B., Salyakina, D., Lichtner, P., Wochnik, G.M., Ising, M., Pütz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M.A., Nickel, T., Künzel, H.E., Fuchs, B., Majer, M., Pfennig, A., Kern, N., Brunner, J., Modell, S., Baghai, T., Deiml, T., Zill, P., Bondy, B., Rupprecht, R., Messer, T., Köhnlein, O., Dabitz, H., Brückl, T., Müller, N., Pfister, H., Lieb, R., Mueller, J.C., Lõhmussaar, E., Strom, T.M., Bettecken, T., Meitinger, T., Uhr, M., Rein, T., Holsboer, F., Muller-Myhsok, B. Nat. Genet. (2004)
- Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Bledsoe, R.K., Montana, V.G., Stanley, T.B., Delves, C.J., Apolito, C.J., McKee, D.D., Consler, T.G., Parks, D.J., Stewart, E.L., Willson, T.M., Lambert, M.H., Moore, J.T., Pearce, K.H., Xu, H.E. Cell (2002)
- Steroid hormone receptor gene expression in human breast cancer cells: inverse relationship between oestrogen and glucocorticoid receptor messenger RNA levels. Hall, R.E., Lee, C.S., Alexander, I.E., Shine, J., Clarke, C.L., Sutherland, R.L. Int. J. Cancer (1990)
- Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins. Kiefer, T.L., Lai, L., Yuan, L., Dong, C., Burow, M.E., Hill, S.M. J. Pineal Res. (2005)
- Hormone resistance in cancer: the role of abnormal steroid receptors. Sluyser, M. Critical reviews in oncogenesis. (1994)
- HPLC micromethod for simultaneous measurement of estradiol, progesterone, androgen and glucocorticoid receptor levels. Application to breast cancer biopsies. Formento, J.L., Moll, J.L., Francoual, M., Krebs, B.P., Milano, G., Renee, N., Khater, R., Frenay, M., Namer, M. European journal of cancer & clinical oncology. (1987)
- HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection. Mirani, M., Elenkov, I., Volpi, S., Hiroi, N., Chrousos, G.P., Kino, T. J. Immunol. (2002)
- Variations of the human glucocorticoid receptor gene (NR3C1): pathological and in vitro mutations and polymorphisms. Bray, P.J., Cotton, R.G. Hum. Mutat. (2003)
- Novel genetic polymorphisms in the NR3C1 (glucocorticoid receptor) gene in a Japanese population. Koyano, S., Saito, Y., Sai, K., Kurose, K., Ozawa, S., Nakajima, T., Matsumoto, K., Saito, H., Shirao, K., Yoshida, T., Minami, H., Ohtsu, A., Saijo, N., Sawada, J. Drug Metab. Pharmacokinet. (2005)
- Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element. Pearce, D., Yamamoto, K.R. Science (1993)
- Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. Tai, P.K., Albers, M.W., Chang, H., Faber, L.E., Schreiber, S.L. Science (1992)
- Diversity and specialization of mammalian SWI/SNF complexes. Wang, W., Xue, Y., Zhou, S., Kuo, A., Cairns, B.R., Crabtree, G.R. Genes Dev. (1996)
- Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Scheinman, R.I., Gualberto, A., Jewell, C.M., Cidlowski, J.A., Baldwin, A.S. Mol. Cell. Biol. (1995)
- Nuclear orphan receptor as a repressor of glucocorticoid receptor transcriptional activity. Trapp, T., Holsboer, F. J. Biol. Chem. (1996)
- Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. Silverstein, A.M., Galigniana, M.D., Chen, M.S., Owens-Grillo, J.K., Chinkers, M., Pratt, W.B. J. Biol. Chem. (1997)
- Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor. Rao, J., Lee, P., Benzeno, S., Cardozo, C., Albertus, J., Robins, D.M., Caplan, A.J. J. Biol. Chem. (2001)
- Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma. Adcock, I.M., Lane, S.J., Brown, C.R., Lee, T.H., Barnes, P.J. J. Exp. Med. (1995)
- Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. Hittelman, A.B., Burakov, D., Iñiguez-Lluhí, J.A., Freedman, L.P., Garabedian, M.J. EMBO J. (1999)
- A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity. Schneikert, J., Hübner, S., Martin, E., Cato, A.C. J. Cell Biol. (1999)
- TATA box binding protein induces structure in the recombinant glucocorticoid receptor AF1 domain. Kumar, R., Volk, D.E., Li, J., Lee, J.C., Gorenstein, D.G., Thompson, E.B. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Glucocorticoid receptor inhibits transforming growth factor-beta signaling by directly targeting the transcriptional activation function of Smad3. Song, C.Z., Tian, X., Gelehrter, T.D. Proc. Natl. Acad. Sci. U.S.A. (1999)
- BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. Hsiao, P.W., Fryer, C.J., Trotter, K.W., Wang, W., Archer, T.K. Mol. Cell. Biol. (2003)
- Identification of glucocorticoid receptor domains involved in transrepression of transforming growth factor-beta action. Li, G., Wang, S., Gelehrter, T.D. J. Biol. Chem. (2003)
- Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation. Itoh, M., Adachi, M., Yasui, H., Takekawa, M., Tanaka, H., Imai, K. Mol. Endocrinol. (2002)
- Structure-function analysis of squirrel monkey FK506-binding protein 51, a potent inhibitor of glucocorticoid receptor activity. Denny, W.B., Prapapanich, V., Smith, D.F., Scammell, J.G. Endocrinology (2005)
- STAMP, a Novel Predicted Factor Assisting TIF2 Actions in Glucocorticoid Receptor-Mediated Induction and Repression. He, Y., Simons, S.S. Mol. Cell. Biol. (2007)
- Repression of interleukin-5 transcription by the glucocorticoid receptor targets GATA3 signaling and involves histone deacetylase recruitment. Jee, Y.K., Gilmour, J., Kelly, A., Bowen, H., Richards, D., Soh, C., Smith, P., Hawrylowicz, C., Cousins, D., Lee, T., Lavender, P. J. Biol. Chem. (2005)
- Heat shock protein is tightly associated with the recombinant human glucocorticoid receptor:glucocorticoid response element complex. Srinivasan, G., Patel, N.T., Thompson, E.B. Mol. Endocrinol. (1994)
- STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene. Lerner, L., Henriksen, M.A., Zhang, X., Darnell, J.E. Genes Dev. (2003)
- Structural and biochemical mechanisms for the specificity of hormone binding and coactivator assembly by mineralocorticoid receptor. Li, Y., Suino, K., Daugherty, J., Xu, H.E. Mol. Cell (2005)
- Calreticulin Is a receptor for nuclear export. Holaska, J.M., Black, B.E., Love, D.C., Hanover, J.A., Leszyk, J., Paschal, B.M. J. Cell Biol. (2001)
- Macromolecular translocation inhibitor II (Zn(2+)-binding protein, parathymosin) interacts with the glucocorticoid receptor and enhances transcription in vivo. Okamoto, K., Isohashi, F. J. Biol. Chem. (2005)
- The glucocorticoid receptor is specifically expressed in the stromal compartment of the human endometrium. Bamberger, A.M., Milde-Langosch, K., Löning, T., Bamberger, C.M. J. Clin. Endocrinol. Metab. (2001)
- Estrogen Receptor Antagonist Fulvestrant (ICI 182,780) Inhibits the Anti-Inflammatory Effect of Glucocorticoids. Cuzzocrea, S., Bruscoli, S., Crisafulli, C., Mazzon, E., Agostini, M., Mui??, C., Esposito, E., Di Virgilio, R., Meli, R., Vegeto, E., Maggi, A., Riccardi, C. Mol. Pharmacol. (2007)