Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CCRIS 1564 methyl-nitroso-cyanamide

Synonyms: AG-F-14510, LS-7524, CTK4H1352, AKOS006275950, BRN 2347248, ...

Hidaka, K. et al., Ishizawa, M. et al., Inui, N. et al.

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Disease relevance of N-cyano-N-methyl-nitrous amide

A potent carcinogen, methylnitrosocyanamide was used to induce revertants in a strain of Escherichia coli carrying an amber mutation in a gene for tryptophan (trp) biosynthesis and an ochre mutation in a gene for alkaline phosphatase biosynthesis [1].
Chromosomal aberration, mutation and morphological transformation of Syrian hamster embryonic cells after exposure to methylnitrosocyanamide [2].

High impact information on N-cyano-N-methyl-nitrous amide

The formation of methylnitrosocyanamide (MNC), a carcionogenic N-nitroso compound, from methylguanidine (MG) and NaNO2 in simulated gastric juice (SGJ) and in the stomachs of rats was quantitatively investigated [3].
About 90% of the Trp+ revertants induced by methylnitrosocyanamide were due to mutations in suppressor genes, and 85% of the suppressor mutations occurred in gene supE [1].

References

Mode of mutagenic action of methylnitrosocyanamide, a potent carcinogen. Hidaka, K., Ishizawa, M., Otsuji, N., Endo, H. Cancer Res. (1978) [Pubmed]
Chromosomal aberration, mutation and morphological transformation of Syrian hamster embryonic cells after exposure to methylnitrosocyanamide. Inui, N., Taketomi, M. Mutat. Res. (1977) [Pubmed]
Formation of methylnitrosocyanamide from methylguanidine and sodium nitrite in simulated gastric juice and in stomachs of rats: quantitative estimation by a mutagenicity assay. Ishizawa, M., Utsunomiya, T., Kinoshita, N., Endo, H. J. Natl. Cancer Inst. (1979) [Pubmed]

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