The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Diclofop     2-[4-(2,4-dichlorophenoxy) phenoxy]propanoi...

Synonyms: Diclofop acid, SureCN66474, AGN-PC-00KI1L, HOE 21079, LS-121352, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of DICHLORFOP ACID

  • Sphingomonas paucimobilis mineralized 1.5 micrograms diclofop-methyl.mL-1 to diclofop acid within 54 h [1].
  • Diclofop was administered orally at 7-56 mg/kg body weight per day to male Wistar rats for 2, 4, 7 or 14 consecutive days and some effects regarded as early hepatic markers of PPs were studied [2].
 

High impact information on DICHLORFOP ACID

  • We have determined the crystal structures at up to 2.5-A resolution of the CT domain of yeast ACC in complex with the herbicide haloxyfop or diclofop [3].
  • Diclofop residues determined with hydrolysis were approximately double those without hydrolysis, suggesting that a significant portion of diclofop was excreted in the conjugated form [4].
  • The selective grass herbicides diclofop, haloxyfop, and trifop were found to be potent reversible inhibitors of acetyl-CoA carboxylase from the susceptible species barley, corn, and wheat [5].
  • In biotype R2, which exhibited a medium level of resistance, there was an increased rate of oxidation of the aryl ring of diclofop, a reaction most likely catalyzed by a cytochrome P450 enzyme [6].
  • Markers of hepatocellular proliferation (S- and M-phase) indicated that mitogenesis was transient and declined despite continuation of diclofop treatment [2].
 

Anatomical context of DICHLORFOP ACID

  • A study was performed to determine whether diclofop (2-(4-(2,4-dichlorophenoxy) phenoxy)propionic acid), introduced as a herbicide, exhibits the properties of peroxisome proliferators (PPs) [2].
 

Associations of DICHLORFOP ACID with other chemical compounds

  • Removal of diclofop methyl by the bacterial consortium was increased by 36% when a larger surface to volume ratio was provided by glass beads that allowed extensive biofilm formation [7].
  • Interestingly, we also demonstrate that herbicides themselves are potent inducers of the amount of total P450 and laurate/diclofop hydroxylase activies [8].
  • The parallel induction of lauric acid (omega-1)-hydroxylase and diclofop hydroxylase activities suggests that both compounds proceeds from the same or very similar forms of P450 [8].

References

  1. Degradation of diclofop-methyl by pure cultures of bacteria isolated from Manitoban soils. Smith-Greenier, L.L., Adkins, A. Can. J. Microbiol. (1996) [Pubmed]
  2. Studies of early hepatocellular proliferation and peroxisomal proliferation in Wistar rats treated with herbicide diclofop. Palut, D., Ludwicki, J.K., Kostka, G., Kopec-Szlezak, J., Wiadrowska, B., Lembowicz, K. Toxicology (2001) [Pubmed]
  3. Molecular basis for the inhibition of the carboxyltransferase domain of acetyl-coenzyme-A carboxylase by haloxyfop and diclofop. Zhang, H., Tweel, B., Tong, L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Determination of the herbicide diclofop in human urine. Cessna, A.J., Grover, R. J. Chromatogr. (1992) [Pubmed]
  5. Kinetic characterization, stereoselectivity, and species selectivity of the inhibition of plant acetyl-CoA carboxylase by the aryloxyphenoxypropionic acid grass herbicides. Rendina, A.R., Felts, J.M., Beaudoin, J.D., Craig-Kennard, A.C., Look, L.L., Paraskos, S.L., Hagenah, J.A. Arch. Biochem. Biophys. (1988) [Pubmed]
  6. Lolium rigidum, a pool of resistance mechanisms to ACCase inhibitor herbicides. De Prado, J.L., Osuna, M.D., Heredia, A., De Prado, R. J. Agric. Food Chem. (2005) [Pubmed]
  7. The role of interactions, sessile growth and nutrient amendments on the degradative efficiency of a microbial consortium. Wolfaardt, G.M., Lawrence, J.R., Robarts, R.D., Caldwell, D.E. Can. J. Microbiol. (1994) [Pubmed]
  8. Induction and inactivation of a cytochrome P450 confering herbicide resistance in wheat seedlings. Forthoffer, N., Helvig, C., Dillon, N., Benveniste, I., Zimmerlin, A., Tardif, F., Salaün, J.P. European journal of drug metabolism and pharmacokinetics. (2001) [Pubmed]
 
WikiGenes - Universities