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Chemical Compound Review

Diclofop     2-[4-(2,4-dichlorophenoxy) phenoxy]propanoi...

Synonyms: Diclofop acid, SureCN66474, AGN-PC-00KI1L, HOE 21079, LS-121352, ...
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Disease relevance of DICHLORFOP ACID

  • Sphingomonas paucimobilis mineralized 1.5 micrograms diclofop-methyl.mL-1 to diclofop acid within 54 h [1].
  • Diclofop was administered orally at 7-56 mg/kg body weight per day to male Wistar rats for 2, 4, 7 or 14 consecutive days and some effects regarded as early hepatic markers of PPs were studied [2].

High impact information on DICHLORFOP ACID

  • We have determined the crystal structures at up to 2.5-A resolution of the CT domain of yeast ACC in complex with the herbicide haloxyfop or diclofop [3].
  • Diclofop residues determined with hydrolysis were approximately double those without hydrolysis, suggesting that a significant portion of diclofop was excreted in the conjugated form [4].
  • The selective grass herbicides diclofop, haloxyfop, and trifop were found to be potent reversible inhibitors of acetyl-CoA carboxylase from the susceptible species barley, corn, and wheat [5].
  • In biotype R2, which exhibited a medium level of resistance, there was an increased rate of oxidation of the aryl ring of diclofop, a reaction most likely catalyzed by a cytochrome P450 enzyme [6].
  • Markers of hepatocellular proliferation (S- and M-phase) indicated that mitogenesis was transient and declined despite continuation of diclofop treatment [2].

Anatomical context of DICHLORFOP ACID

  • A study was performed to determine whether diclofop (2-(4-(2,4-dichlorophenoxy) phenoxy)propionic acid), introduced as a herbicide, exhibits the properties of peroxisome proliferators (PPs) [2].

Associations of DICHLORFOP ACID with other chemical compounds

  • Removal of diclofop methyl by the bacterial consortium was increased by 36% when a larger surface to volume ratio was provided by glass beads that allowed extensive biofilm formation [7].
  • Interestingly, we also demonstrate that herbicides themselves are potent inducers of the amount of total P450 and laurate/diclofop hydroxylase activies [8].
  • The parallel induction of lauric acid (omega-1)-hydroxylase and diclofop hydroxylase activities suggests that both compounds proceeds from the same or very similar forms of P450 [8].


  1. Degradation of diclofop-methyl by pure cultures of bacteria isolated from Manitoban soils. Smith-Greenier, L.L., Adkins, A. Can. J. Microbiol. (1996) [Pubmed]
  2. Studies of early hepatocellular proliferation and peroxisomal proliferation in Wistar rats treated with herbicide diclofop. Palut, D., Ludwicki, J.K., Kostka, G., Kopec-Szlezak, J., Wiadrowska, B., Lembowicz, K. Toxicology (2001) [Pubmed]
  3. Molecular basis for the inhibition of the carboxyltransferase domain of acetyl-coenzyme-A carboxylase by haloxyfop and diclofop. Zhang, H., Tweel, B., Tong, L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Determination of the herbicide diclofop in human urine. Cessna, A.J., Grover, R. J. Chromatogr. (1992) [Pubmed]
  5. Kinetic characterization, stereoselectivity, and species selectivity of the inhibition of plant acetyl-CoA carboxylase by the aryloxyphenoxypropionic acid grass herbicides. Rendina, A.R., Felts, J.M., Beaudoin, J.D., Craig-Kennard, A.C., Look, L.L., Paraskos, S.L., Hagenah, J.A. Arch. Biochem. Biophys. (1988) [Pubmed]
  6. Lolium rigidum, a pool of resistance mechanisms to ACCase inhibitor herbicides. De Prado, J.L., Osuna, M.D., Heredia, A., De Prado, R. J. Agric. Food Chem. (2005) [Pubmed]
  7. The role of interactions, sessile growth and nutrient amendments on the degradative efficiency of a microbial consortium. Wolfaardt, G.M., Lawrence, J.R., Robarts, R.D., Caldwell, D.E. Can. J. Microbiol. (1994) [Pubmed]
  8. Induction and inactivation of a cytochrome P450 confering herbicide resistance in wheat seedlings. Forthoffer, N., Helvig, C., Dillon, N., Benveniste, I., Zimmerlin, A., Tardif, F., Salaün, J.P. European journal of drug metabolism and pharmacokinetics. (2001) [Pubmed]
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