Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

galactose (2S,3R,4S,5R,6R)-6- (hydroxymethyl)oxane-2...

Synonyms: Hexose, Gal-alpha, D-galactose, alpha-D-Gal, Galactose (NF), ...

Vallejo, V. et al., Suzuki, Y. et al., Greger, I.H. et al., Tajima, M. et al.

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Disease relevance of galactose

Influenza viruses differ in their ability to recognize SA-galactose (Gal) linkages, depending on the animal hosts from which they are isolated [1].

High impact information on galactose

Both genes are part of the galactose (GAL) gene cluster which is transcriptionally activated to high levels in the presence of galactose [2].
Duplicate upstream activating sequences in the promoter region of the Saccharomyces cerevisiae GAL7 gene [3].
Nevertheless, the most contrasting was the type of glycosidic linkage between 5-N-acetyl-neuraminic acid (Neu5Ac) and galactose (Gal) expressed in central nervous system (CNS) [4].

References

Sialic acid species as a determinant of the host range of influenza A viruses. Suzuki, Y., Ito, T., Suzuki, T., Holland, R.E., Chambers, T.M., Kiso, M., Ishida, H., Kawaoka, Y. J. Virol. (2000) [Pubmed]
Poly(A) signals control both transcriptional termination and initiation between the tandem GAL10 and GAL7 genes of Saccharomyces cerevisiae. Greger, I.H., Proudfoot, N.J. EMBO J. (1998) [Pubmed]
Duplicate upstream activating sequences in the promoter region of the Saccharomyces cerevisiae GAL7 gene. Tajima, M., Nogi, Y., Fukasawa, T. Mol. Cell. Biol. (1986) [Pubmed]
Differential expression of sialic acid on porcine organs during the maturation process. Vallejo, V., Reyes-Leyva, J., Hernández, J., Ramírez, H., Delannoy, P., Zenteno, E. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2000) [Pubmed]

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