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Chemical Compound Review:

L-Lyxopyranose (3R,4R,5S)-oxane-2,3,4,5- tetrol

Synonyms: AG-F-27743, SureCN8331810, CHEBI:62321, CTK1C1174, AKOS015892634, ...

Muiry, J.A. et al., Badia, J. et al., Sánchez, J.C. et al.

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Disease relevance of C01508

Activation of a cryptic gene encoding a kinase for L-xylulose opens a new pathway for the utilization of L-lyxose by Escherichia coli [1].
L-Rhamnose, L-mannose and L-lyxose each elicited an alkaline pH change when added to energy-depleted suspensions of L-rhamnose-grown Salmonella typhimurium LT2, Klebsiella pneumoniae, Klebsiella aerogenes, Erwinia carotovora carotovora and Erwinia carotovora atroseptica [2].
Escherichia coli cannot grow on L-lyxose, a pentose analog of the 6-deoxyhexose L-rhamnose, which supports the growth of this and other enteric bacteria [3].

High impact information on C01508

1. An alkaline pH change occurred when L-rhamnose, L-mannose or L-lyxose was added to L-rhamnose-grown energy-depleted suspensions of strains of Escherichia coli [2].
4. The relative rates of H+ symport and of sugar metabolism, and the relative values of their kinetic parameters, suggested that the physiological role of the transport activity was primarily for utilization of L-rhamnose, not for L-mannose or L-lyxose [2].
However, rhamnulose kinase did not phosphorylate L-xylulose sufficiently to support the growth of wild-type E. coli on L-lyxose [3].

References

Activation of a cryptic gene encoding a kinase for L-xylulose opens a new pathway for the utilization of L-lyxose by Escherichia coli. Sánchez, J.C., Gímenez, R., Schneider, A., Fessner, W.D., Baldomà, L., Aguilar, J., Badía, J. J. Biol. Chem. (1994) [Pubmed]
Proton-linked L-rhamnose transport, and its comparison with L-fucose transport in Enterobacteriaceae. Muiry, J.A., Gunn, T.C., McDonald, T.P., Bradley, S.A., Tate, C.G., Henderson, P.J. Biochem. J. (1993) [Pubmed]
L-lyxose metabolism employs the L-rhamnose pathway in mutant cells of Escherichia coli adapted to grow on L-lyxose. Badia, J., Gimenez, R., Baldomá, L., Barnes, E., Fessner, W.D., Aguilar, J. J. Bacteriol. (1991) [Pubmed]

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