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Chemical Compound Review

Nipent     (6R)-10-[(2R,4S,5R)-4- hydroxy-5...

Synonyms: Oncopent, Coforin, Vidarbine, pentostatin, CO-Vidarabine, ...
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Disease relevance of pentostatin

  • Pretreatment with 500 micrograms/kg DCF shows a small, but statistically significant, preservation of both ATP and phosphorylation potential during hypoxia and initial recovery [1].

High impact information on pentostatin

  • In all, 11 pts were pretreated with either splenectomy (n=6), interferon alpha (n=9) or deoxycoformycin (dCF) (n=3) or all procedures in sequence [2].
  • Of these, three patients were studied at the time of diagnosis, 12 in relapse after interferon (IFN) therapy, eight with a partial response after IFN and one with a complete response after 2-deoxycoformycin (DCF) therapy [3].
  • Only FLU and 2-CdA activated the apoptosis and DCF showed a minor apoptotic pathway amount [4].
  • In July 1985, the patient began intravenous deoxycoformycin (DCF) therapy, and after 1 year complete peripheral blood and bone marrow remission was achieved [5].
  • We are using immortalized stromal cell lines resistant to deoxycoformycin (dCF) to select transduced murine HSC containing human ADA in vitro [6].

Gene context of pentostatin


  1. 31P NMR spectroscopy of perinatal hypoxic-ischemic brain damage: a model to evaluate neuroprotective drugs in immature rats. Williams, G.D., Palmer, C., Roberts, R.L., Heitjan, D.F., Smith, M.B. NMR in biomedicine. (1992) [Pubmed]
  2. An update: 12-year follow-up of patients with hairy cell leukemia following treatment with 2-chlorodeoxyadenosine. Jehn, U., Bartl, R., Dietzfelbinger, H., Haferlach, T., Heinemann, V. Leukemia (2004) [Pubmed]
  3. Serum interleukin-1 beta levels correlate with neoplastic bulk in hairy cell leukemia. Cimino, G., Annino, L., Giona, F., Sgadari, C., Di Gregorio, A.O., Cava, M.C., Cimino, G., Mandelli, F. Leukemia (1991) [Pubmed]
  4. Apoptosis induction with three nucleoside analogs on freshly isolated B-chronic lymphocytic leukemia cells. Zinzani, P.L., Tosi, P., Visani, G., Martinelli, G., Farabegoli, P., Buzzi, M., Ottaviani, E., Salvucci, M., Bendandi, M., Zaccaria, A. Am. J. Hematol. (1994) [Pubmed]
  5. Sezary syndrome in a patient with hairy cell leukemia in remission. Crump, M., Sutton, D.M., Pantalony, D. Cancer (1991) [Pubmed]
  6. Gene transfer into murine hematopoietic stem cells and bone marrow stromal cells. Luskey, B.D., Lim, B., Apperley, J.F., Orkin, S.H., Williams, D.A. Ann. N. Y. Acad. Sci. (1990) [Pubmed]
  7. Plasma levels of soluble CD8 antigen and interleukin-2 receptor antigen in patients with hairy cell leukemia, relationship with splenectomy and with clinical response to therapy. Ho, A.D., Grossmann, M., Knauf, W., Martin, H., Trümper, L., Zwingers, T., Sonnen, R., Pralle, H., Hunstein, W. Leukemia (1989) [Pubmed]
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