Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-D-88091 N-methylbutane-1,4-diamine

Synonyms: CHEBI:17166, HMDB03661, CTK4C4199, AKOS009159150, AC1L981Z, ...

Katoh, A. et al., Biastoff, S. et al., Hoye, T.R. et al.

Hoye, Bjorklund, Koltun, Renner,

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Disease relevance of N-Methylputrescine

Recombinant MPO protein expressed in Escherichia coli formed a homodimer and deaminated N-methylputrescine more efficiently than symmetrical diamines [1].

High impact information on N-Methylputrescine

Oxidative deamination of N-methylputrescine was found to be stereoselective; the pro-S hydrogen atom is removed with 6-10:1 selectivity [2].
Putrescine N-methyltransferase (PMT, EC 2.1.1.53) catalyses the S-adenosyl- L-methionine (SAM or AdoMet)-dependent methylation of putrescine to N-methylputrescine within the biosynthetic pathways of calystegines, nicotine, and tropane alkaloids in medicinal plants and produces S-adenosyl- L-homocysteine (SAH or AdoHcy) [3].

Associations of N-Methylputrescine with other chemical compounds

Nicotine biosynthesis in Nicotiana species requires an oxidative deamination of N-methylputrescine, catalyzed by N-methylputrescine oxidase (MPO) [1].

Analytical, diagnostic and therapeutic context of N-Methylputrescine

Molecular Cloning of N-methylputrescine Oxidase from Tobacco [1].

References

Molecular Cloning of N-methylputrescine Oxidase from Tobacco. Katoh, A., Shoji, T., Hashimoto, T. Plant Cell Physiol. (2007) [Pubmed]
N-methylputrescine oxidation during cocaine biosynthesis: study of prochiral methylene hydrogen discrimination using the remote isotope method. Hoye, T.R., Bjorklund, J.A., Koltun, D.O., Renner, M.K. Org. Lett. (2000) [Pubmed]
Colorimetric Activity Measurement of a Recombinant Putrescine N-Methyltransferase from Datura stramonium. Biastoff, S., Teuber, M., Zhou, Z.S., Dr??ger, B. Planta Med. (2006) [Pubmed]

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