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Chemical Compound Review:

AGN-PC-00IO43 (hydroxy- (4,8,12,16,20,24,28,32,36...

Synonyms: CTK8G9924

Jun, L. et al., Ferella, M. et al., Okada, K. et al., Kang, D. et al., Zahiri, H.S. et al., et al.

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Disease relevance of Solanesyl diphosphate

Purification of solanesyl-diphosphate synthase from Micrococcus luteus. A new class of prenyltransferase [1].
Both E. coli and S. cerevisiae expressing the sdsA gene mainly produced solanesyl diphosphate, which resulted in the synthesis of UQ-9 without any noticeable effect on the growth of the cells [2].

High impact information on Solanesyl diphosphate

A Solanesyl-diphosphate Synthase Localizes in Glycosomes of Trypanosoma cruzi [3].
Two solanesyl diphosphate synthases, designated SPS1 and SPS2, which are responsible for the synthesis of the isoprenoid side chain of either plastoquinone or ubiquinone in Arabidopsis thaliana, were identified [4].
These two different subcellular localizations are thought to be the reflection of their roles in solanesyl diphosphate synthesis in two different parts: presumably SPS1 and SPS2 for the side chains of ubiquinone and plastoquinone, respectively [4].
Biosynthesis of ubiquinone-9 was studied by incubating rat liver mitochondria with p-hydroxy[U-14C]benzoate, solanesyl diphosphate and S-adenosyl-L-methionine [5].

Analytical, diagnostic and therapeutic context of Solanesyl diphosphate

Thin layer chromatography indicated that the Rsdds enzyme resulted in relatively much less solanesyl diphosphate formation [6].

References

Purification of solanesyl-diphosphate synthase from Micrococcus luteus. A new class of prenyltransferase. Ohnuma, S., Koyama, T., Ogura, K. J. Biol. Chem. (1991) [Pubmed]
Cloning of the sdsA gene encoding solanesyl diphosphate synthase from Rhodobacter capsulatus and its functional expression in Escherichia coli and Saccharomyces cerevisiae. Okada, K., Kamiya, Y., Zhu, X., Suzuki, K., Tanaka, K., Nakagawa, T., Matsuda, H., Kawamukai, M. J. Bacteriol. (1997) [Pubmed]
A Solanesyl-diphosphate Synthase Localizes in Glycosomes of Trypanosoma cruzi. Ferella, M., Montalvetti, A., Rohloff, P., Miranda, K., Fang, J., Reina, S., Kawamukai, M., B??a, J., Nilsson, D., Pravia, C., Katzin, A., Cassera, M.B., Aslund, L., Andersson, B., Docampo, R., Bontempi, E.J. J. Biol. Chem. (2006) [Pubmed]
Identification and subcellular localization of two solanesyl diphosphate synthases from Arabidopsis thaliana. Jun, L., Saiki, R., Tatsumi, K., Nakagawa, T., Kawamukai, M. Plant Cell Physiol. (2004) [Pubmed]
Evidence that the decarboxylation reaction occurs before the first methylation in ubiquinone biosynthesis in rat liver mitochondria. Kang, D., Takeshige, K., Isobe, R., Minakami, S. Eur. J. Biochem. (1991) [Pubmed]
Biochemical characterization of the decaprenyl diphosphate synthase of Rhodobacter sphaeroides for coenzyme Q(10) production. Zahiri, H.S., Noghabi, K.A., Shin, Y.C. Appl. Microbiol. Biotechnol. (2006) [Pubmed]

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