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MeSH Review

Microbodies

 
 
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Disease relevance of Microbodies

 

High impact information on Microbodies

 

Biological context of Microbodies

 

Anatomical context of Microbodies

 

Associations of Microbodies with chemical compounds

 

Gene context of Microbodies

  • Both fission and fusion of microbodies with parental PML bodies indicate a loss of structural integrity of the bodies, dependent on the state of the surrounding chromatin [7].
  • The proteins encoded by those genes were predicted to have a signal peptide for the secretory pathway, which is consistent with earlier biochemical work that localized allantoinase activity to microbodies and endoplasmic reticulum (Hanks et al., 1981) [18].
  • The PEX11 proteins are required for the division of microbodies in trypanosomes, yeast and mammals, and a role of coatomer in this process has been suggested [19].
  • Rab39 contains conserved motifs involved in phosphate/guanosine binding and a microbody C-terminal targeting signal [20].
  • Peroxin 2 is essential for the import of many proteins into the microbodies of yeasts and mammals [21].
 

Analytical, diagnostic and therapeutic context of Microbodies

References

  1. Response of microbodies in Morris hepatoma 9618A to clofibrate. Tsukada, H., Mochizuki, Y., Itabashi, M., Gotoh, M., Morris, H.P. J. Natl. Cancer Inst. (1975) [Pubmed]
  2. Cloning and sequencing of the malate synthase gene from Hansenula polymorpha. Bruinenberg, P.G., Blaauw, M., Kazemier, B., Ab, G. Yeast (1990) [Pubmed]
  3. Matrical inclusions induced by clofibrate in hepatic microbodies of rats fed 2-acetylaminofluorene. Tsukada, H., Mochizuki, Y., Gotoh, M. J. Natl. Cancer Inst. (1975) [Pubmed]
  4. Import of a DHFR hybrid protein into glycosomes in vivo is not inhibited by the folate-analogue aminopterin. Häusler, T., Stierhof, Y.D., Wirtz, E., Clayton, C. J. Cell Biol. (1996) [Pubmed]
  5. Compartmentation of phosphoglycerate kinase in Trypanosoma brucei plays a critical role in parasite energy metabolism. Blattner, J., Helfert, S., Michels, P., Clayton, C. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. Leishmania major expresses a single dihydroxyacetone phosphate acyltransferase localized in the glycosome, important for rapid growth and survival at high cell density and essential for virulence. Zufferey, R., Ben Mamoun, C. J. Biol. Chem. (2006) [Pubmed]
  7. Chromatin contributes to structural integrity of promyelocytic leukemia bodies through a SUMO-1-independent mechanism. Eskiw, C.H., Dellaire, G., Bazett-Jones, D.P. J. Biol. Chem. (2004) [Pubmed]
  8. Expression of a betaine aldehyde dehydrogenase gene in rice, a glycinebetaine nonaccumulator, and possible localization of its protein in peroxisomes. Nakamura, T., Yokota, S., Muramoto, Y., Tsutsui, K., Oguri, Y., Fukui, K., Takabe, T. Plant J. (1997) [Pubmed]
  9. Biogenesis and metabolic significance of microbodies in urate-utilizing yeasts. Veenhuis, M., Hoogkamer-Te Niet, M.C., Middelhoven, W.J. Antonie Van Leeuwenhoek (1985) [Pubmed]
  10. Two tandemly linked identical genes code for the glycosomal glyceraldehyde-phosphate dehydrogenase in Trypanosoma brucei. Michels, P.A., Poliszczak, A., Osinga, K.A., Misset, O., Van Beeumen, J., Wierenga, R.K., Borst, P., Opperdoes, F.R. EMBO J. (1986) [Pubmed]
  11. Import of fructose bisphosphate aldolase into the glycosomes of Trypanosoma brucei. Clayton, C.E. J. Cell Biol. (1987) [Pubmed]
  12. Biochemistry of protozoan microbodies: peroxisomes, alpha-glycerophosphate oxidase bodies, hydrogenosomes. Müller, M. Annu. Rev. Microbiol. (1975) [Pubmed]
  13. Peroxisomal assembly: membrane proliferation precedes the induction of the abundant matrix proteins in the methylotrophic yeast Candida boidinii. Veenhuis, M., Goodman, J.M. J. Cell. Sci. (1990) [Pubmed]
  14. Investigation of the glyoxysome-peroxisome transition in germinating cucumber cotyledons using double-label immunoelectron microscopy. Titus, D.E., Becker, W.M. J. Cell Biol. (1985) [Pubmed]
  15. Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei. Opperdoes, F.R., Baudhuin, P., Coppens, I., De Roe, C., Edwards, S.W., Weijers, P.J., Misset, O. J. Cell Biol. (1984) [Pubmed]
  16. Topogenesis of microbody enzymes: a sequence comparison of the genes for the glycosomal (microbody) and cytosolic phosphoglycerate kinases of Trypanosoma brucei. Osinga, K.A., Swinkels, B.W., Gibson, W.C., Borst, P., Veeneman, G.H., Van Boom, J.H., Michels, P.A., Opperdoes, F.R. EMBO J. (1985) [Pubmed]
  17. Glucose is toxic to glycosome-deficient trypanosomes. Furuya, T., Kessler, P., Jardim, A., Schnaufer, A., Crudder, C., Parsons, M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  18. Functional characterization of allantoinase genes from Arabidopsis and a nonureide-type legume black locust. Yang, J., Han, K.H. Plant Physiol. (2004) [Pubmed]
  19. Binding of coatomer by the PEX11 C-terminus is not required for function. Maier, A.G., Schulreich, S., Bremser, M., Clayton, C. FEBS Lett. (2000) [Pubmed]
  20. Rab39, a novel Golgi-associated Rab GTPase from human dendritic cells involved in cellular endocytosis. Chen, T., Han, Y., Yang, M., Zhang, W., Li, N., Wan, T., Guo, J., Cao, X. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  21. Compartmentation of enzymes in a microbody, the glycosome, is essential in Trypanosoma brucei. Guerra-Giraldez, C., Quijada, L., Clayton, C.E. J. Cell. Sci. (2002) [Pubmed]
  22. The beta-oxidation system in catalase-free microbodies of the filamentous fungus Neurospora crassa. Purification of a multifunctional protein possessing 2-enoyl-CoA hydratase, L-3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxyacyl-CoA epimerase activities. Thieringer, R., Kunau, W.H. J. Biol. Chem. (1991) [Pubmed]
  23. The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number. Roper, J.R., Güther, M.L., Macrae, J.I., Prescott, A.R., Hallyburton, I., Acosta-Serrano, A., Ferguson, M.A. J. Biol. Chem. (2005) [Pubmed]
  24. Microbody of methanol-grown yeasts. Localization of catalase and flavin-dependent alcohol oxidase in the isolated microbody. Fukui, S., Kawamoto, S., Yasuhara, S., Tanaka, A., Osumi, M. Eur. J. Biochem. (1975) [Pubmed]
  25. Binding of glycosomes to endoplasmic reticulum and to intermediate filaments in cardiac conduction fibers. Rybicka, K. J. Histochem. Cytochem. (1981) [Pubmed]
  26. Cloning, sequencing and expression of a cDNA encoding an antigen from the Myxosporean parasite causing the proliferative kidney disease of salmonid fish. Saulnier, D., Brémont, M., de Kinkelin, P. Mol. Biochem. Parasitol. (1996) [Pubmed]
 
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