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Chemical Compound Review

AG-F-00124     2,3-dimethoxy-5-methyl-6- (3,7,11,15,19,23...

Synonyms: CTK8F8757, AC1L40XN
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Disease relevance of C01967


Psychiatry related information on C01967


High impact information on C01967


Chemical compound and disease context of C01967

  • In mumps virus-infected cultures there were transient reductions in the contents of cholesterol, dolichol, and ubiquinone-9 in the cultures, whereas the reduction in the ubiquinone-10 level was progressive, reaching 20% of its original value 21 days after infection [3].

Biological context of C01967


Anatomical context of C01967


Associations of C01967 with other chemical compounds


Gene context of C01967

  • Strain SW-45T was chemotaxonomically characterized by having ubiquinone-9 (Q-9) as the major respiratory lipoquinone and C16 : 0, C18 : 1omega9c and C16 : 1omega9c as the predominant fatty acids [19].
  • Increased redox ratios of coenzyme Q(9) and coenzyme Q(10) are also evident in quadriceps, heart and liver tissues in mdx mouse, but not brain [20].

Analytical, diagnostic and therapeutic context of C01967


  1. Relation of mevalonate synthesis to mitochondrial ubiquinone content and respiratory function in cultured neuroblastoma cells. Maltese, W.A., Aprille, J.R. J. Biol. Chem. (1985) [Pubmed]
  2. Development and fertility in Caenorhabditis elegans clk-1 mutants depend upon transport of dietary coenzyme Q8 to mitochondria. Jonassen, T., Marbois, B.N., Faull, K.F., Clarke, C.F., Larsen, P.L. J. Biol. Chem. (2002) [Pubmed]
  3. Ubiquinone-10 protects neurons from virus-induced degeneration. Edlund, C., Holmberg, K., Dallner, G., Norrby, E., Kristensson, K. J. Neurochem. (1994) [Pubmed]
  4. Insensitivity of ubiquinone biosynthesis in glioblastoma cells to an epileptogenic drug, U18666A. Jeng, I., Klemm, N., Proctor, B. J. Neurochem. (1984) [Pubmed]
  5. The coupling of light-induced electron transfer and proton uptake as derived from crystal structures of reaction centres from Rhodopseudomonas viridis modified at the binding site of the secondary quinone, QB. Lancaster, C.R., Michel, H. Structure (1997) [Pubmed]
  6. Insulin-like growth factor I (IGF-1) supplementation prevents diabetes-induced alterations in coenzymes Q9 and Q10. Wold, L.E., Muralikrishnan, D., Albano, C.B., Norby, F.L., Ebadi, M., Ren, J. Acta diabetologica. (2003) [Pubmed]
  7. Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity. Padilla, S., Jonassen, T., Jiménez-Hidalgo, M.A., Fernández-Ayala, D.J., López-Lluch, G., Marbois, B., Navas, P., Clarke, C.F., Santos-Ocaña, C. J. Biol. Chem. (2004) [Pubmed]
  8. Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver. Kalén, A., Appelkvist, E.L., Chojnacki, T., Dallner, G. J. Biol. Chem. (1990) [Pubmed]
  9. 5-demethylubiquinone-9-methyltransferase from rat liver mitochondria. Characterization, localization, and solubilization. Houser, R.M., Olson, R.E. J. Biol. Chem. (1977) [Pubmed]
  10. Promotion of carcinogenesis and oxidative stress by dietary cholesterol in rat prostate. Homma, Y., Kondo, Y., Kaneko, M., Kitamura, T., Nyou, W.T., Yanagisawa, M., Yamamoto, Y., Kakizoe, T. Carcinogenesis (2004) [Pubmed]
  11. Mitochondrial activities of rat heart during ageing. Castelluccio, C., Baracca, A., Fato, R., Pallotti, F., Maranesi, M., Barzanti, V., Gorini, A., Villa, R.F., Parenti Castelli, G., Marchetti, M. Mech. Ageing Dev. (1994) [Pubmed]
  12. Identification of the quinone species in cyanide-sensitive and cyanide-insensitive mitochondria of Moniliella tomentosa. Vanderleyden, J., Meyers, M., Verachtert, H. Biochem. J. (1980) [Pubmed]
  13. 1-Methyl-4-phenyl-2,3-dihydropyridinium is transformed by ubiquinone to the selective nigrostriatal toxin 1-methyl-4-phenylpyridinium. Shi, H., Noguchi, N., Xu, Y., Niki, E. FEBS Lett. (1999) [Pubmed]
  14. Halomonas marisflavae sp. nov., a halophilic bacterium isolated from the Yellow Sea in Korea. Yoon, J.H., Choi, S.H., Lee, K.C., Kho, Y.H., Kang, K.H., Park, Y.H. Int. J. Syst. Evol. Microbiol. (2001) [Pubmed]
  15. Coenzyme Q10 in plasma and erythrocytes: comparison of antioxidant levels in healthy probands after oral supplementation and in patients suffering from sickle cell anemia. Niklowitz, P., Menke, T., Wiesel, T., Mayatepek, E., Zschocke, J., Okun, J.G., Andler, W. Clin. Chim. Acta (2002) [Pubmed]
  16. Effects of dietary iron overload on progression in chemical hepatocarcinogenesis. Stål, P., Wang, G.S., Olsson, J.M., Eriksson, L.C. Liver (1999) [Pubmed]
  17. Influence of ubiquinone on the inhibitory effect of adriamycin on mitochondrial oxidative phosphorylation. Muhammed, H., Kurup, C.K. Biochem. J. (1984) [Pubmed]
  18. Developmental changes in the respiratory chain of Ascaris mitochondria. Takamiya, S., Kita, K., Wang, H., Weinstein, P.P., Hiraishi, A., Oya, H., Aoki, T. Biochim. Biophys. Acta (1993) [Pubmed]
  19. Marinobacter litoralis sp. nov., a moderately halophilic bacterium isolated from sea water from the East Sea in Korea. Yoon, J.H., Shin, D.Y., Kim, I.G., Kang, K.H., Park, Y.H. Int. J. Syst. Evol. Microbiol. (2003) [Pubmed]
  20. Ubiquinol: a potential biomarker for tissue energy requirements and oxidative stress. Miles, L., Miles, M.V., Tang, P.H., Horn, P.S., Quinlan, J.G., Wong, B., Wenisch, A., Bove, K.E. Clin. Chim. Acta (2005) [Pubmed]
  21. Half-life of ubiquinone-9 in rat tissues. Thelin, A., Schedin, S., Dallner, G. FEBS Lett. (1992) [Pubmed]
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