Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

PubChem8265 (2S)-2-hydroxybutanoic acid

Synonyms: AG-F-12925, CHEBI:50613, ANW-73908, AK-34732, KB-04989, ...

Hofmeister, A.E. et al., Johnson, R.N. et al., Zeiler, T.A. et al., Cavill, I. et al.

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Disease relevance of C05984

The in vitro RBC values (lactate dehydrogenase, 2-hydroxybutyrate dehydrogenase, hemolysis, potassium, 2,3 DPG, ATP) were at least equal to those in RBCs collected by conventional whole-blood donation [1].

High impact information on C05984

The results from 1H-NMR spectroscopy and, after degradation of 2-hydroxybutyrate to propionate, the transcarboxylase assay consistently indicated that the deamination of L-threonine catalyzed by L-serine dehydratase of P. asaccharolyticus proceeds with inversion and retention in a 2:1 ratio [2].
Myoglobin was compared with the activities of creatine kinase, 2-hydroxybutyrate dehydrogenase and glutamate-oxaloacetate transaminase in relation to electrocardiographic criteria of myocardial damage [3].
Serum 2-hydroxybutyrate dehydrogenase activity and ineffective erythropoiesis [4].

References

Automated blood component collection with the MCS 3p cell separator: evaluation of three protocols for buffy coat-poor and white cell-reduced packed red cells and plasma. Zeiler, T.A., Kretschmer, V. Transfusion (1997) [Pubmed]
The iron-sulfur-cluster-containing L-serine dehydratase from Peptostreptococcus asaccharolyticus. Stereochemistry of the deamination of L-threonine. Hofmeister, A.E., Berger, S., Buckel, W. Eur. J. Biochem. (1992) [Pubmed]
Serum myoglobin concentration as an index of myocardial damage after cardiac surgery. Johnson, R.N., Neutze, J.M., Kerr, A.R., Gillain, B. International journal of cardiology. (1983) [Pubmed]
Serum 2-hydroxybutyrate dehydrogenase activity and ineffective erythropoiesis. Cavill, I., Ricketts, C., Griffiths, G.J., Elder, G.H., Trevett, D. British medical journal. (1978) [Pubmed]

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