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Gene Review

GOT1  -  glutamic-oxaloacetic transaminase 1, soluble

Homo sapiens

Synonyms: ASTQTL1, Aspartate aminotransferase, cytoplasmic, Cysteine aminotransferase, cytoplasmic, Cysteine transaminase, cytoplasmic, GIG18, ...
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Disease relevance of GOT1


High impact information on GOT1


Chemical compound and disease context of GOT1


Biological context of GOT1


Anatomical context of GOT1


Associations of GOT1 with chemical compounds


Other interactions of GOT1


Analytical, diagnostic and therapeutic context of GOT1


  1. Antitumoural Effects of the Pyridyl Cyanoguanidine CHS 828 on Three Different Types of Neuroendocrine Tumours Xenografted to Nude Mice. Johanson, V., Arvidsson, Y., Kolby, L., Bernhardt, P., Sward, C., Nilsson, O., Ahlman, H. Neuroendocrinology (2005) [Pubmed]
  2. Uptake of meta-iodobenzylguanidine in neuroendocrine tumours is mediated by vesicular monoamine transporters. Kölby, L., Bernhardt, P., Levin-Jakobsen, A.M., Johanson, V., Wängberg, B., Ahlman, H., Forssell-Aronsson, E., Nilsson, O. Br. J. Cancer (2003) [Pubmed]
  3. Fusion of ETV6 to GOT1 in a case with myelodysplastic syndrome and t(10;12)(q24;p13). Janssen, H., Wlodarska, I., Mecucci, C., Hagemeijer, A., Vandenberghe, P., Marynen, P., Cools, J. Haematologica (2006) [Pubmed]
  4. CSF enzymes in lacunar and cortical stroke. Donnan, G.A., Zapf, P., Doyle, A.E., Bladin, P.F. Stroke (1983) [Pubmed]
  5. Hepatic irradiation in primary and metastatic liver cancer. Hatano, K., Mikuriya, S., Oda, T., Makino, M., Hada, Y. Cancer Chemother. Pharmacol. (1989) [Pubmed]
  6. The role of lactic acid in autocrine B-cell growth stimulation. Pike, S.E., Markey, S.P., Ijames, C., Jones, K.D., Tosato, G. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  7. Vitamin B6 status in women with postpartum depression. Livingston, J.E., MacLeod, P.M., Applegarth, D.A. Am. J. Clin. Nutr. (1978) [Pubmed]
  8. Description of a new variant in the glutamate-oxaloacetate transaminase system by thin-layer agarose gel isoelectric focusing. Farnbacher, O., Weidinger, S. Electrophoresis (1991) [Pubmed]
  9. The maximum activities of hexokinase, phosphorylase, phosphofructokinase, glycerol phosphate dehydrogenases, lactate dehydrogenase, octopine dehydrogenase, phosphoenolpyruvate carboxykinase, nucleoside diphosphatekinase, glutamate-oxaloacetate transaminase and arginine kinase in relation to carbohydrate utilization in muscles from marine invertebrates. Zammit, V.A., Newsholme, E.A. Biochem. J. (1976) [Pubmed]
  10. Brain neuroprotection by scavenging blood glutamate. Zlotnik, A., Gurevich, B., Tkachov, S., Maoz, I., Shapira, Y., Teichberg, V.I. Exp. Neurol. (2007) [Pubmed]
  11. The salubrious effect of tamoxifen [correction of Tamaxifen] on serum marker enzymes, glycoproteins, and lysosomal enzymes level in breast cancer woman. Thangaraju, M., Rameshbabu, J., Vasavi, H., Ilanchezhian, S., Vinitha, R., Sachdanandam, P. Mol. Cell. Biochem. (1998) [Pubmed]
  12. Enzymes in the cerebrospinal fluid in diagnosis of brain death. Voisin, C., Wattel, F., Scherpereel, P., Gosselin, B., Chopin, C. Resuscitation. (1975) [Pubmed]
  13. Clinical studies on the effect of Neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer. Bandyopadhyay, U., Biswas, K., Sengupta, A., Moitra, P., Dutta, P., Sarkar, D., Debnath, P., Ganguly, C.K., Banerjee, R.K. Life Sci. (2004) [Pubmed]
  14. Acral myxoinflammatory fibroblastic sarcoma with unique clonal chromosomal changes. Lambert, I., Debiec-Rychter, M., Guelinckx, P., Hagemeijer, A., Sciot, R. Virchows Arch. (2001) [Pubmed]
  15. Assignment of LIPA, associated with human acid lipase deficiency, to human chromosome 10 and comparative assignment to mouse chromosome 19. Koch, G., Lalley, P.A., McAvoy, M., Shows, T.B. Somatic Cell Genet. (1981) [Pubmed]
  16. Confirmation of a de novo duplication, dup(10)(q24 leads to q26), by GOT1 gene dosage studies. Tomkins, D.J., Gitelman, B.J., Roberts, M.H. Hum. Genet. (1983) [Pubmed]
  17. Genetic polymorphism of human glutamate oxaloacetate transaminase (GOT1) detected using isoelectric focusing and a sensitive and positive staining method. Nakanaga, M., Nadano, D., Yasuda, T., Tenjo, E., Sawazaki, K., Iida, R., Fujiki, N., Kishi, K. Int. J. Legal Med. (1991) [Pubmed]
  18. Multicolor spectral karyotype analysis of a transplantable human ileal carcinoid. Sjögren, H., Nilsson, O., Behrendt, M., Kölby, L., Jacobsen Levin, A.M., Ahlman, H., Stenman, G. Int. J. Mol. Med. (2000) [Pubmed]
  19. Prenatal prediction of duplication 10q24 leads to qter by gene dosage of GOT1 on uncultured amniotic cells. Dallapiccola, B., Novelli, G., Micara, G., Ferranti, G., Pachi, A., Magnani, M. Prenat. Diagn. (1983) [Pubmed]
  20. Respiratory properties and malate metabolism in Percoll-purified mitochondria isolated from pineapple, Ananas comosus (L.) Merr. cv. smooth cayenne. Hong, H.T., Nose, A., Agarie, S. J. Exp. Bot. (2004) [Pubmed]
  21. Serum creatine kinase levels in untreated hospitalized adolescents during acute psychosis. Hermesh, H., Stein, D., Manor, I., Shechtmann, T., Blumensohn, R., Meged, S., Shiloh, R., Benjamini, Y., Weizman, A. Journal of the American Academy of Child and Adolescent Psychiatry. (2002) [Pubmed]
  22. Distribution of lactic dehydrogenase and glutamate oxaloacetate transaminase in buffalo spermatozoa. Gupta, R.S., Srivastava, R.K. Cellular and molecular biology, including cyto-enzymology. (1981) [Pubmed]
  23. The hepatotoxicity of parenteral protein hydrolysate-containing solutions. Garnica, A.D. Ann. Clin. Lab. Sci. (1976) [Pubmed]
  24. Assignment to chromosome 16 of a gene necessary for the expression of human mitochondrial glutamate oxaloacetate transaminase (aspartate aminotransferase) (E.C. Tolley, E., van Heyningen, V., Brown, R., Bobrow, M., Craig, I.W. Biochem. Genet. (1980) [Pubmed]
  25. Report : the protective effect of aloe vera juice on lindane induced hepatotoxicity and genotoxicity. Oe, E., Eo, F., If, U., Ej, A. Pakistan journal of pharmaceutical sciences (2006) [Pubmed]
  26. Ethanol enhances de novo synthesis of high density lipoprotein cholesterol. Cluette, J.E., Mulligan, J.J., Noring, R., Doyle, K., Hojnacki, J. Proc. Soc. Exp. Biol. Med. (1984) [Pubmed]
  27. Fluorimetric assay of serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and alpha-hydroxybutyrate dehydrogenase by solution and solid surface fluorescent methods. Rietz, B., Guilbault, G.G. Anal. Chim. Acta (1975) [Pubmed]
  28. Genetic homogeneity, high-resolution mapping, and mutation analysis of the urofacial (Ochoa) syndrome and exclusion of the glutamate oxaloacetate transaminase gene (GOT1) in the critical region as the disease gene. Wang, C.Y., Huang, Y.Q., Shi, J.D., Marron, M.P., Ruan, Q.G., Hawkins-Lee, B., Ochoa, B., She, J.X. Am. J. Med. Genet. (1999) [Pubmed]
  29. Evaluation of the cytotoxicity of sodium valproate on primary cultured rat hepatocytes. Takeuchi, T., Sugimoto, T., Nishida, N., Kobayashi, Y. Neuropediatrics. (1988) [Pubmed]
  30. GOT1 xenografted to nude mice: a unique model for in vivo studies on SSTR-mediated radiation therapy of carcinoid tumors. Nilsson, O., Kölby, L., Bernhardt, P., Forssell-Aronsson, E., Johanson, V., Ahlman, H. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  31. Nutritional status in elderly population in kibbutzim. Havivi, E., Levin, N., Reshef, A. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1985) [Pubmed]
  32. Abnormal liver function associated with occupational exposure to dimethylformamide and glutathione S-transferase polymorphisms. Luo, J.C., Cheng, T.J., Kuo, H.W., Chang, M.J. Biomarkers (2005) [Pubmed]
  33. The possibility of prenatal diagnosis by gene dosage: confirmation of duplication 10q24 to qter from GOT-1 activity in fetal erythrocytes. Dallapiccola, B., Pachì, A., Ferranti, G., Micara, G., Magnani, M., Dachà, M.U. Prenat. Diagn. (1981) [Pubmed]
  34. Low dose injectable contraceptive norethisterone enanthate 20mg monthly - II. Metabolic side effects. Bamji, M.S., Safaya, S., Prema, K. Contraception. (1981) [Pubmed]
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