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Chemical Compound Review

CHEMBL10118     (5S)-5-methyl-5-(4- phenoxyphenyl)-3...

Synonyms: SureCN673443, CHEBI:106738, DB07778, AC1L9K5S, (-)-famoxadone, ...
 
 
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Disease relevance of Famoxadone

  • The effects of famoxadone binding on electron transfer were also studied in a series of Rhodobacter sphaeroides cyt bc(1) mutants involving residues at the interface between the Rieske protein and cyt c(1) and/or cyt b [1].
 

High impact information on Famoxadone

  • Effect of famoxadone on photoinduced electron transfer between the iron-sulfur center and cytochrome c1 in the cytochrome bc1 complex [1].
  • Steady-state and tight-binding inhibition kinetics; as well as direct binding measurements with famoxadone (FAM) and methoxyacrylate stilbene (MOAS), indicated that FAM is a non-competitive inhibitor of the enzyme while methoxyacrylate stilbene (MOAS) is better described as a mixed-competitive inhibitor with respect to substrate [2].
  • The feasibility of using liquid chromatography/ electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS) for determining 2 fungicides (fludioxonil and famoxadone) in tomato pulp, pear purée, and concentrated lemon juice has been evaluated [3].
  • Dissipation of the fungicides famoxadone and trifloxystrobin in basidiocarps of Agaricus bisporus was studied in mushroom growing rooms [4].
  • The synthesis of various oxazolidinone ring systems and the development of the structure-activity relationships that led to the discovery of famoxadone are described [5].
 

Analytical, diagnostic and therapeutic context of Famoxadone

References

  1. Effect of famoxadone on photoinduced electron transfer between the iron-sulfur center and cytochrome c1 in the cytochrome bc1 complex. Xiao, K., Engstrom, G., Rajagukguk, S., Yu, C.A., Yu, L., Durham, B., Millett, F. J. Biol. Chem. (2003) [Pubmed]
  2. Mechanistic differences in inhibition of ubiquinol cytochrome c reductase by the proximal Qo-site inhibitors famoxadone and methoxyacrylate stilbene. Pember, S.O., Fleck, L.C., Moberg, W.K., Walker, M.P. Arch. Biochem. Biophys. (2005) [Pubmed]
  3. Determination of fludioxonil and famoxadone in processed fruits and vegetables by liquid chromatography/electrospray tandem mass spectrometry. Sannino, A., Bandini, M. Journal of AOAC International. (2005) [Pubmed]
  4. Residue evaluation of famoxadone and trifloxystrobin in cultivated mushrooms. Chrysayi-Tokousbalides, M., Kastanias, M.A., Coward, S., Philippoussis, A., Diamantopoulou, P. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (2006) [Pubmed]
  5. Famoxadone: the discovery and optimisation of a new agricultural fungicide. Sternberg, J.A., Geffken, D., Adams, J.B., Pöstages, R., Sternberg, C.G., Campbell, C.L., Moberg, W.K. Pest Manag. Sci. (2001) [Pubmed]
  6. Synthesis and structural analysis of the active enantiomer of famoxadone, a potent inhibitor of cytochrome bc1. Zheng, Y.J., Shapiro, R., Marshall, W.J., Jordan, D.B. Bioorg. Med. Chem. Lett. (2000) [Pubmed]
 
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