The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Michellamine A     (1S,3S)-5-[3-[4-[(1S,3S)-6,8- dihydroxy-1,3...

Synonyms: Michellamine B, CHEMBL325222, CHEBI:66385, CHEBI:66386, NSC649324, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of AIDS-003609

  • HIV replication in cells in which infection was already fully established or in chronically infected cells was unaffected by michellamine B [1].

High impact information on AIDS-003609


Anatomical context of AIDS-003609


Associations of AIDS-003609 with other chemical compounds


Analytical, diagnostic and therapeutic context of AIDS-003609

  • Preliminary results show that MEKC with LIF is feasible for the sensitive detection of michellamine B in serum [5].
  • A refined, three-step process (solvent-solvent partitioning, centrifugal partition chromatography and HPLC) has been developed and applied to the scaled-up production of michellamine B for preclinical drug development [6].
  • Determination of michellamine B in biological fluids by high-performance liquid chromatography with fluorescence detection [7].


  1. Michellamine B, a novel plant alkaloid, inhibits human immunodeficiency virus-induced cell killing by at least two distinct mechanisms. McMahon, J.B., Currens, M.J., Gulakowski, R.J., Buckheit, R.W., Lackman-Smith, C., Hallock, Y.F., Boyd, M.R. Antimicrob. Agents Chemother. (1995) [Pubmed]
  2. Pharmacokinetics of michellamine B, a naphthylisoquinoline alkaloid with in vitro activity against human immunodeficiency virus types 1 and 2, in the mouse and dog. Supko, J.G., Malspeis, L. Antimicrob. Agents Chemother. (1995) [Pubmed]
  3. Anti-HIV michellamines from Ancistrocladus korupensis. Boyd, M.R., Hallock, Y.F., Cardellina, J.H., Manfredi, K.P., Blunt, J.W., McMahon, J.B., Buckheit, R.W., Bringmann, G., Schäffer, M., Cragg, G.M. J. Med. Chem. (1994) [Pubmed]
  4. Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis. Hallock, Y.F., Manfredi, K.P., Dai, J.R., Cardellina, J.H., Gulakowski, R.J., McMahon, J.B., Schäffer, M., Stahl, M., Gulden, K.P., Bringmann, G., François, G., Boyd, M.R. J. Nat. Prod. (1997) [Pubmed]
  5. Micellar electrokinetic chromatography of the anti-human immunodeficiency virus (HIV) agent michellamine B with absorption and laser-induced fluorescence detection. Chan, K.C., Majadly, F., McCloud, T.G., Muschik, G.M., Issaq, H.J., Snader, K.M. Electrophoresis (1994) [Pubmed]
  6. Preparative separation of naphthyltetrahydroisoquinoline alkaloids from Ancistrocladus korupensis by centrifugal partition chromatography. Hallock, Y.F., Dai, J., Bokesch, H.R., Dillah, K.B., Manfredi, K.P., Cardellina, J.H., Boyd, M.R. Journal of chromatography. A. (1994) [Pubmed]
  7. Determination of michellamine B in biological fluids by high-performance liquid chromatography with fluorescence detection. Supko, J.G., Malspeis, L. Anal. Biochem. (1994) [Pubmed]
WikiGenes - Universities