Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

CYCLOPEPTOLIDE 2-[ (3S,6S,9S,15S,18S,21S,24S,27S) -15,18...

Synonyms: AC1LA46A, 159170-92-0

Emmer, G. et al., Hommel, U. et al., Jachez, B. et al., Harant, H. et al., Besemer, J. et al., et al.

Harant, Lettner, Hofer, Oberhauser, de Vries, Lindley,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on CYCLOPEPTOLIDE

The cyclopeptolide CAM741 selectively inhibits cotranslational translocation of vascular cell adhesion molecule 1 (VCAM1), a process that is dependent on its signal peptide [1].
Derivatives of a novel cyclopeptolide. 2. Synthesis, activity against multidrug resistance in CHO and KB cells in vitro, and structure-activity relationships [2].
Derivatives of a novel cyclopeptolide. 1. Synthesis, antifungal activity, and structure-activity relationships [3].
The three-dimensional structure of cyclopeptolide HUN-7293, a naturally-occurring inhibitor of cell adhesion molecule expression, has been determined from nuclear magnetic resonance data recorded in solution and from X-ray diffraction analysis of single crystals [4].
SDZ 280-446, a novel semi-synthetic cyclopeptolide: in vitro and in vivo circumvention of the P-glycoprotein-mediated tumour cell multidrug resistance [5].

Anatomical context of CYCLOPEPTOLIDE

A series of derivatives of the novel cyclopeptolide 1 was prepared, and their ability to chemosensitize multi drug resistant CHO and KB cells in vitro was evaluated [2].
We have recently identified CAM741, a derivative of a fungus-derived cyclopeptolide that acts as a selective inhibitor of VCAM1 synthesis in endothelial cells [6].

Associations of CYCLOPEPTOLIDE with other chemical compounds

Reversal of multidrug resistance by novel cyclosporin A analogues and the cyclopeptolide SDZ 214-103 biosynthesized in vitro [7].
SDZ 280-125: a cyclopeptolide endowed with an in vitro cyclosporin A-like profile of activity for the reversion of the P-glycoprotein-mediated multidrug resistance of tumor cells [8].

References

The Translocation Inhibitor CAM741 Interferes with Vascular Cell Adhesion Molecule 1 Signal Peptide Insertion at the Translocon. Harant, H., Lettner, N., Hofer, L., Oberhauser, B., de Vries, J.E., Lindley, I.J. J. Biol. Chem. (2006) [Pubmed]
Derivatives of a novel cyclopeptolide. 2. Synthesis, activity against multidrug resistance in CHO and KB cells in vitro, and structure-activity relationships. Emmer, G., Grassberger, M.A., Schulz, G., Boesch, D., Gavériaux, C., Loor, F. J. Med. Chem. (1994) [Pubmed]
Derivatives of a novel cyclopeptolide. 1. Synthesis, antifungal activity, and structure-activity relationships. Emmer, G., Grassberger, M.A., Meingassner, J.G., Schulz, G., Schaude, M. J. Med. Chem. (1994) [Pubmed]
The 3D-structure of a natural inhibitor of cell adhesion molecule expression. Hommel, U., Weber, H.P., Oberer, L., Naegeli, H.U., Oberhauser, B., Foster, C.A. FEBS Lett. (1996) [Pubmed]
SDZ 280-446, a novel semi-synthetic cyclopeptolide: in vitro and in vivo circumvention of the P-glycoprotein-mediated tumour cell multidrug resistance. Loor, F., Boesch, D., Gavériaux, C., Jachez, B., Pourtier-Manzanedo, A., Emmer, G. Br. J. Cancer (1992) [Pubmed]
Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1. Besemer, J., Harant, H., Wang, S., Oberhauser, B., Marquardt, K., Foster, C.A., Schreiner, E.P., de Vries, J.E., Dascher-Nadel, C., Lindley, I.J. Nature (2005) [Pubmed]
Reversal of multidrug resistance by novel cyclosporin A analogues and the cyclopeptolide SDZ 214-103 biosynthesized in vitro. Schwabe, K., Steinheider, G., Lawen, A., Traber, R., Hildebrandt, A. J. Cancer Res. Clin. Oncol. (1995) [Pubmed]
SDZ 280-125: a cyclopeptolide endowed with an in vitro cyclosporin A-like profile of activity for the reversion of the P-glycoprotein-mediated multidrug resistance of tumor cells. Jachez, B., Boesch, D., Emmer, G., Loor, F. Anticancer Drugs (1994) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.