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Chemical Compound Review:

Dorevan 1-[10-(2-dimethylaminopropyl) phenothiazin...

Synonyms: Phenoctyl, Largon, Propiomazina, propiomazine, Propiomazinum, ...

Midgren, B. et al., Dehlin, O. et al., Smith, D.B. et al., Fayez, M. et al., Benkestock, K., et al.

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Disease relevance of CB 1678

We have now investigated the effects of propiomazine, a phenothiazine hypnotic, in a double-blind randomized cross-over study of oxygen saturation and apneas during sleep and other sleep variables in 12 non-obese hypoxemic but clinically stable theophylline-treated COPD patients (PaO2 8.1 kPa, PaCO2 5.6 kPa, FEV1 31% of predicted value) [1].

Psychiatry related information on CB 1678

Parturients in whom meperidine HCl, propiomazine HCl, and scopolamine were used for analgesia and amnesia in labor and delivery were studied to determine the efficacy and safety of physostigmine reversal after delivery [2].
Concerning side-effects, bad taste was reported more frequently in the zopiclone group and restless legs in the propiomazine group [3].

High impact information on CB 1678

A single iv injection of 0.31, 0.62, 1.25, 2.5, 5, 10, or 20 mg/kg body wt of a phenothiazine derivative, propiomazine (PP), into male rats significantly (P less than 0.05) increased plasma prolactin concentrations [4].
Physostigmine's effect on diminished fetal heart rate variability caused by scopolamine, meperidine and propiomazine [5].

Associations of CB 1678 with other chemical compounds

A comparison of zopiclone and propiomazine as hypnotics in outpatients: a multicentre, double-blind, randomized, parallel-group comparison of zopiclone and propiomazine in insomniacs [3].

Analytical, diagnostic and therapeutic context of CB 1678

Determination of propiomazine and its N-demethyl metabolite in plasma by gas chromatography with alkali flame ionization detection [6].
Effects of propiomazine on the EEG sleep of normal subjects [7].
Determination of propiomazine in rat plasma by direct injection on coupled liquid chromatography columns with electrochemical detection [8].

References

Effects of single doses of propiomazine, a phenothiazine hypnotic, on sleep and oxygenation in patients with stable chronic obstructive pulmonary disease. Midgren, B., Hansson, L., Ahlmann, S., Elmqvist, D. Respiration; international review of thoracic diseases. (1990) [Pubmed]
Physostigmine reversal of sedation in parturients. Smith, D.B., Clark, R.B., Stephens, S.R., Sherman, R.L., Hyde, M.L. Anesth. Analg. (1976) [Pubmed]
A comparison of zopiclone and propiomazine as hypnotics in outpatients: a multicentre, double-blind, randomized, parallel-group comparison of zopiclone and propiomazine in insomniacs. Dehlin, O., Bengtsson, C., Rubin, B. Current medical research and opinion. (1997) [Pubmed]
Effect of propiomazine on plasma prolactin in the rat: counteraction by L-dopa. Fayez, M., Ahmed, H.H., Quadri, S.K. Proc. Soc. Exp. Biol. Med. (1985) [Pubmed]
Physostigmine's effect on diminished fetal heart rate variability caused by scopolamine, meperidine and propiomazine. Boehm, F.H., Egilmez, A., Smith, B.E. Journal of perinatal medicine. (1977) [Pubmed]
Determination of propiomazine and its N-demethyl metabolite in plasma by gas chromatography with alkali flame ionization detection. Hartvig, P., Ahs, U., Wickström, G. J. Chromatogr. (1980) [Pubmed]
Effects of propiomazine on the EEG sleep of normal subjects. Almqvist, M., Liljenberg, B., Hetta, J., Rimon, R., Hambert, G., Roos, B.E. Pharmacol. Toxicol. (1987) [Pubmed]
Determination of propiomazine in rat plasma by direct injection on coupled liquid chromatography columns with electrochemical detection. Benkestock, K. J. Chromatogr. B Biomed. Sci. Appl. (1997) [Pubmed]

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