Disease relevance of propyl gallate

• Histological examination revealed significantly increased incidences of hyperplasia in the groups given BHA together with SA or PG at the prefundic region or at the mid region respectively [1].

High impact information on propyl gallate

• In this assay this activity is sensitive to n-propyl-gallate, an inhibitor of the alternative oxidase [2].
• Neuronal apoptosis was suppressed by pre-treatment with the antioxidants, propyl gallate (PG) and N-t-butyl-phenylnitrone (BPN), or overexpression of human Bcl-2 [3].
• Exposure to NAC fibrils increased also the nuclear translocation of nuclear factor kappa B (NF-kappaB) and enhanced its DNA-binding activity, which was inhibited by PG and BPN more efficiently in neurons than in astrocytes [3].
• At a concentration of 0.2-2.0 g/liter and 6 g/liter, respectively, PPD and NPG were shown to effectively retard fluorescence fading without notably decreasing the initial emission intensity; two requisites were that the modified PVA used must be rather fresh and that the mounted preparations be examined within a few days [4].
• The results allow the establishment of a decreasing order of antioxidant power: PG > PHC > PC >> alpha-TOH > PI > PF [5].

Biological context of propyl gallate

• The absolute oral bioavailability of PG (administered as an HPB complex) in rats was low (5%) suggesting extensive metabolism or incomplete absorption [6].
• Moreover, both frameshift (TA98) and base substitution (TA100) bacteria indicator strains demonstrate an enhanced mutagenesis to 4NQO in the presence of the propyl-gallate [7].
• On the other hand, compared when they were formulated alone, the increase of PG and the diminution of BHA degradation kinetics were observed [8].

Anatomical context of propyl gallate

• Other antioxidants that produced lower but significant (P < 0.05) inhibition of oocyte maturation included propyl gallate (PG; GVBD = 70.3%), 2,4,5-trihydroxybutrophenone (THBP; GVBD = 71.4%), and lauryl gallate (LG; GVBD = 71.4%) [9].

References