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Chemical Compound Review:

Sauzivamycin 5-amino-9-[3,4-dihydroxy-5...

Synonyms: sangivamycin, NSC-65346, SureCN12284269, Neuro_000028, Neuro_000078, ...

Nomura, T. et al., Pootoolal, J. et al., Usuki, Y. et al., Grünewald, J. et al., Vachkova, R. et al., et al.

Usuki, Adachi, Fujita, Ichimura, Iio, Taniguchi,

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High impact information on NSC65346

We report the sequencing and annotation of the biosynthetic gene cluster for the glycopeptide antibiotic from Streptomyces toyocaensis NRRL15009, the first complete sequence for a teicoplanin class glycopeptide [1].
Chemo- and regioselective peptide cyclization triggered by the N-terminal fatty acid chain length: the recombinant cyclase of the calcium-dependent antibiotic from Streptomyces coelicolor [2].
A new antibiotic from Streptomyces sp., tetrapol A159, active against various fungi, a promising compound for the control of plant diseases, was studied for its genotoxic effects [3].
The anti-proliferative effect of azatyrosine, a newly discovered antibiotic from Streptomyces, was examined in Balb/c-originated serum-free mouse embryo (SFME) cells and transformed ras/myc SFME cells which have activated human c-Ha-ras genes [4].
Dactinomycin, a peptide antibiotic from Streptomyces spp., is a classical agent which inhibits DNA replication [5].

Biological context of NSC65346

Structure-activity relationship studies on UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02. Part 5: Roles of the 9-membered dilactone-ring moiety in respiratory inhibition [6].

Associations of NSC65346 with other chemical compounds

Borrelidin, an antibiotic from Streptomyces rochei, was found to be an angiogenesis inhibitor in a rat aorta matrix culture model which forms capillary vessels in vitro [7].

References

Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009. Pootoolal, J., Thomas, M.G., Marshall, C.G., Neu, J.M., Hubbard, B.K., Walsh, C.T., Wright, G.D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
Chemo- and regioselective peptide cyclization triggered by the N-terminal fatty acid chain length: the recombinant cyclase of the calcium-dependent antibiotic from Streptomyces coelicolor. Grünewald, J., Sieber, S.A., Marahiel, M.A. Biochemistry (2004) [Pubmed]
Specific recombinogenic activity of a new polyene antibiotic. Vachkova, R., Kappas, A., Tyagunenko, E., Markaki, M., Voutsinas, G. Cell. Mol. Life Sci. (1998) [Pubmed]
Non-transformed, but not ras/myc-transformed, serum-free mouse embryo cells recover from growth suppression by azatyrosine. Nomura, T., Ryoyama, K., Okada, G., Matano, S., Nakamura, S., Kameyama, T. Jpn. J. Cancer Res. (1992) [Pubmed]
Dactinomycin is a competitive neurokinin-2 receptor antagonist. Delay-Goyet, P., Lundberg, J.M. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
Structure-activity relationship studies on UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02. Part 5: Roles of the 9-membered dilactone-ring moiety in respiratory inhibition. Usuki, Y., Adachi, N., Fujita, K., Ichimura, A., Iio, H., Taniguchi, M. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. Wakabayashi, T., Kageyama, R., Naruse, N., Tsukahara, N., Funahashi, Y., Kitoh, K., Watanabe, Y. J. Antibiot. (1997) [Pubmed]

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