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Chemical Compound Review

Borrelidin     (1R,2R)-2-[ (2S,4E,6Z,8R,9S,11R,13S,15S...

Synonyms: Borrelidine, AC1NUR4C, NSC612237, 7184-60-3
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Disease relevance of NSC612237


High impact information on NSC612237


Biological context of NSC612237


Anatomical context of NSC612237


Associations of NSC612237 with other chemical compounds


Gene context of NSC612237


Analytical, diagnostic and therapeutic context of NSC612237

  • Sequence analysis indicates that the macrolide ring of borrelidin is formed by a modular polyketide synthase (PKS) (borA1-A6), a result that was confirmed by disruption of borA3 [12].
  • By using a HPLC UV/Vis absorbance spectral library we could confirm that this compound was identical with the macrolide antibiotic borrelidin [13].


  1. A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases. Ruan, B., Bovee, M.L., Sacher, M., Stathopoulos, C., Poralla, K., Francklyn, C.S., Söll, D. J. Biol. Chem. (2005) [Pubmed]
  2. Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation. Olano, C., Moss, S.J., Braña, A.F., Sheridan, R.M., Math, V., Weston, A.J., Méndez, C., Leadlay, P.F., Wilkinson, B., Salas, J.A. Mol. Microbiol. (2004) [Pubmed]
  3. Establishment of a quantitative mouse dorsal air sac model and its application to evaluate a new angiogenesis inhibitor. Funahashi, Y., Wakabayashi, T., Semba, T., Sonoda, J., Kitoh, K., Yoshimatsu, K. Oncol. Res. (1999) [Pubmed]
  4. Increased levels of threonyl-tRNA synthetase in a borrelidin-resistant Chinese hamster ovary cell line. Gantt, J.S., Bennett, C.A., Arfin, S.M. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  5. Isolation of a cDNA clone for human threonyl-tRNA synthetase: amplification of the structural gene in borrelidin-resistant cell lines. Kontis, K.J., Arfin, S.M. Mol. Cell. Biol. (1989) [Pubmed]
  6. Genetics of borrelidin resistant mutants of Saccharomyces cerivisiae and properties of their threonyl-tRNA-synthetase. Nass, G., Poralla, K. Mol. Gen. Genet. (1976) [Pubmed]
  7. Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. Wakabayashi, T., Kageyama, R., Naruse, N., Tsukahara, N., Funahashi, Y., Kitoh, K., Watanabe, Y. J. Antibiot. (1997) [Pubmed]
  8. Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae. Tsuchiya, E., Yukawa, M., Miyakawa, T., Kimura, K.I., Takahashi, H. J. Antibiot. (2001) [Pubmed]
  9. Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells. Kawamura, T., Liu, D., Towle, M.J., Kageyama, R., Tsukahara, N., Wakabayashi, T., Littlefield, B.A. J. Antibiot. (2003) [Pubmed]
  10. Homoserine and threonine pools of borrelidin resistant Saccharomyces cerevisiae mutants with an altered aspartokinase. Seibold, M., Nill, K., Poralla, K. Arch. Microbiol. (1981) [Pubmed]
  11. Borrelidin induces the transcription of amino acid biosynthetic enzymes via a GCN4-dependent pathway. Eastwood, E.L., Schaus, S.E. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
  12. Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions. Olano, C., Wilkinson, B., Sánchez, C., Moss, S.J., Sheridan, R., Math, V., Weston, A.J., Braña, A.F., Martin, C.J., Oliynyk, M., Méndez, C., Leadlay, P.F., Salas, J.A. Chem. Biol. (2004) [Pubmed]
  13. Induction of aerial mycelium formation in a bld mutant of Streptomyces tendae by borrelidin--a macrolide antibiotic. Schüz, T.C., Zähner, H. FEMS Microbiol. Lett. (1993) [Pubmed]
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