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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Calcijex     (1S,3S,5Z)-5-[(2E)-2- [(1R,3aR,7aR)-1-[(2R)...

Synonyms: Soltriol, Rocaltrol, Decostriol, Silkis, calcitriol, ...
 
 
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Disease relevance of calcitriol

 

High impact information on calcitriol

  • These experiments also revealed 16 VDREs in 11 of 12 genes induced more than 10-fold in our previous microarray study, five elements in the human gene encoding the epithelial calcium channel TRPV6, as well as novel 1,25(OH2)D3 target genes implicated in regulation of cell cycle progression [2].
  • A screen of the mouse genome identified more than 3000 conserved VDREs, and 158 human genes containing conserved elements were 1,25(OH2)D3-regulated on Hu133A microarrays [2].
  • Stimulation with 10(-8) M 1,25(OH2)D3 increased gene expression for ALP, OC, and Col I [3].
  • 1,25(OH2)D3 did not augment the IFN-gamma-induced polykaryon formation [4].
  • The purpose of this study was to determine the cooperative effects of 1,25(OH2)D3 and the lymphokine gamma interferon (IFN-gamma) on HL-60 cell differentiation [4].
 

Associations of calcitriol with other chemical compounds

 

Gene context of calcitriol

References

  1. RRR-alpha-vitamin E succinate potentiates the antitumor effect of calcitriol in prostate cancer without overt side effects. Yin, Y., Ni, J., Chen, M., Guo, Y., Yeh, S. Clin. Cancer Res. (2009) [Pubmed]
  2. Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Wang, T.T., Tavera-Mendoza, L.E., Laperriere, D., Libby, E., MacLeod, N.B., Nagai, Y., Bourdeau, V., Konstorum, A., Lallemant, B., Zhang, R., Mader, S., White, J.H. Mol. Endocrinol. (2005) [Pubmed]
  3. Development and characterization of conditionally immortalized osteoblast precursor cell lines from human bone marrow stroma. Hicok, K.C., Thomas, T., Gori, F., Rickard, D.J., Spelsberg, T.C., Riggs, B.L. J. Bone Miner. Res. (1998) [Pubmed]
  4. Cooperative effects of gamma interferon and 1-alpha,25-dihydroxyvitamin D3 in inducing differentiation of human promyelocytic leukemia (HL-60) cells. Weinberg, J.B., Misukonis, M.A., Hobbs, M.M., Borowitz, M.J. Exp. Hematol. (1986) [Pubmed]
  5. A phase I pharmacokinetic and pharmacodynamic study of intravenous calcitriol in combination with oral gefitinib in patients with advanced solid tumors. Fakih, M.G., Trump, D.L., Muindi, J.R., Black, J.D., Bernardi, R.J., Creaven, P.J., Schwartz, J., Brattain, M.G., Hutson, A., French, R., Johnson, C.S. Clin. Cancer Res. (2007) [Pubmed]
  6. Effects of parathyroid hormone and 1,25(OH2)D3 on protein glycation in moderate uraemia. Lamb, E.J., Fluck, R.J., Venton, T.R., Woodhead, J.S., Raine, A.E., Dawnay, A.B. Nephron (1996) [Pubmed]
  7. Acute effect of prolactin on the intestinal calcium absorption in normal, pregnant and lactating rats. Krishnamra, N., Thumchai, R., Limlomwongse, L. Bone and mineral. (1990) [Pubmed]
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