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Chemical Compound Review:

Cinalong 2-methoxyethyl cinnamyl 2,6-dimethyl-4-(3...

Synonyms: Siscard, Atelec, Cinaldipine, cilnidipine, AC1NQZJB, ...

Chibana, T. et al., Hosono, M. et al., Nakashima, M. et al., Tominaga, M. et al.

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Disease relevance of cilnidipine

Cilnidipine (FRC-8653), a new dihydropyridine calcium antagonist, was given to 14 hospitalized patients with essential hypertension, and 24-hour ambulatory blood pressure (BP) monitoring was performed [1].

High impact information on cilnidipine

Actions of FRC-8653 on smooth muscle cells of the rabbit mesenteric artery [2].
The amplitudes of action potentials evoked by current stimuli were decreased by FRC-8653, with no significant change in the electrotonic potentials [2].
In vitro and ex vivo Ca-antagonistic effect of 2-methoxyethyl(E)-3-phenyl-2-propen-1-yl(+/-)-1,4-dihydro-2,6-dimethyl- 4-(3- nitrophenyl)pyridine-3,5-dicarboxylate (FRC-8653), a new dihydropyridine derivative [3].
Results suggest that FRC 8653 may be useful for the treatment of patients with hypertension and ischaemic heart disease [4].
No significant change was observed in left ventricular end-diastolic pressure, left ventricular positive dP/dt and heart rate following i.v. administration of FRC 8653 [4].

Biological context of cilnidipine

Myocardial oxygen consumption was dose-dependently decreased by FRC 8653 [4].

Anatomical context of cilnidipine

FRC-8653 inhibited an increase in intracellular free calcium concentration during membrane depolarization in PC12 cells [3].

References

Ambulatory blood pressure monitoring in patients with essential hypertension treated with a new calcium antagonist, cilnidipine. Tominaga, M., Ohya, Y., Tsukashima, A., Kobayashi, K., Takata, Y., Koga, T., Yamashita, Y., Fujishima, Y., Abe, I., Fujishima, M. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. (1997) [Pubmed]
Actions of FRC-8653 on smooth muscle cells of the rabbit mesenteric artery. Nakashima, M., Kou, M., Hashitani, H., Chen, G.F., Ono, H., Kuriyama, H., Suzuki, H. Jpn. J. Pharmacol. (1991) [Pubmed]
In vitro and ex vivo Ca-antagonistic effect of 2-methoxyethyl(E)-3-phenyl-2-propen-1-yl(+/-)-1,4-dihydro-2,6-dimethyl- 4-(3- nitrophenyl)pyridine-3,5-dicarboxylate (FRC-8653), a new dihydropyridine derivative. Hosono, M., Iida, H., Ikeda, K., Hayashi, Y., Dohmoto, H., Hashiguchi, Y., Yamamoto, H., Watanabe, N., Yoshimoto, R. J. Pharmacobio-dyn. (1992) [Pubmed]
Comparative studies of the systemic hemodynamics and myocardial oxygen consumption of FRC 8653, a new Ca++ channel blocker, and nifedipine in anesthetized dogs. Chibana, T., Noguchi, K., Ojiri, Y., Sakanashi, M. Japanese heart journal. (1992) [Pubmed]

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