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Chemical Compound Review

CHEMBL329415     (5Z,8Z,12R,14Z)-12- hydroxyicosa-5,8,14...

Synonyms: CHEBI:247208, LMFA03050012, AC1NR1MT, 12R-HETrE, 12(R)DH-Hete, ...
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High impact information on 12R-HETrE


Anatomical context of 12R-HETrE


  1. Effects of oxo and dihydro metabolites of 12-hydroxy-5,8,10,14-eicosatetraenoic acid on chemotaxis and cytosolic calcium levels in human neutrophils. Powell, W.S., Hashefi, M., Falck, J.R., Chauhan, K., Rokach, J., Wang, S.S., Mills, E., MacLeod, R.J. J. Leukoc. Biol. (1995) [Pubmed]
  2. Metabolism of 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid and other hydroxylated fatty acids by the reductase pathway in porcine polymorphonuclear leukocytes. Wainwright, S., Falck, J.R., Yadagiri, P., Powell, W.S. Biochemistry (1990) [Pubmed]
  3. A biosynthetic pathway generating 12-hydroxy-5,8,14-eicosatrienoic acid from arachidonic acid is active in mouse skin microsomes. Du, L., Yermalitsky, V., Hachey, D.L., Jagadeesh, S.G., Falck, J.R., Keeney, D.S. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  4. Metabolism of 12(R)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(R)-HETE) in corneal tissues: formation of novel metabolites. Nishimura, M., Schwartzman, M.L., Falck, J.R., Lumin, S., Zirrolli, J.A., Murphy, R.C. Arch. Biochem. Biophys. (1991) [Pubmed]
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