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Chemical Compound Review

Cubosic     dihydroxy-oxo-silane

Synonyms: Mikronisil, Kieselsaure, oxosilanediol, H-Ilerit, Bio-Sil, ...
 
 
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Disease relevance of SILICIC ACID

 

Psychiatry related information on SILICIC ACID

  • The relationship between dementia and Al concentrations was U or J shaped--there was a minimum at an Al concentration of 100 micrograms/l. Other constituents or properties such as silicic acid, fluoride, turbidity, iron, and pH all have an effect on the relationship [6].
  • Supplementation of the diet with silicic acid to reduce body burden of aluminum: A miracle cure or useless treatment for Alzheimer's disease [7]?
 

High impact information on SILICIC ACID

  • A set of polycationic peptides (called silaffins) isolated from diatom cell walls were shown to generate networks of silica nanospheres within seconds when added to a solution of silicic acid [8].
  • Processing of conditioned media by sequential chromatography on silicic acid, Con A-Sepharose, and DEAE-Sephacel failed to separate IFN-gamma from the LT activity [9].
  • The antigen bound to DEAE-Sephacel, was not inactivated by mild treatment with base (which hydrolyzes phospholipids) and eluted in ganglioside fractions upon C18 Sep-Pak and upon silicic acid chromatography [10].
  • A monocyte-derived growth factor (MDGF) that stimulates proliferation of fibroblast and smooth muscle cells was purified from mitogen-stimulated human peripheral blood lymphocyte conditioned medium by using anion-exchange, Bio-Sil TSK-250 HPLC gel-permeation chromatography, and NaDodSO4/PAGE [11].
  • This lipid was purified from a pooled kidney preparation by chloroform/methanol extraction, mild alkaline treatment, DEAE-Sephadex and silicic acid column chromatographies, and preparative thin layer chromatography [12].
 

Chemical compound and disease context of SILICIC ACID

 

Biological context of SILICIC ACID

 

Anatomical context of SILICIC ACID

 

Associations of SILICIC ACID with other chemical compounds

  • Lanosterol was identified by silicic acid chromatography and mass spectrometry [24].
  • Using 3H-arachidonic acid as a tracer, we evaluated the effect of glucose stimulation upon the incorporation of this fatty acid into islet phospholipids and prostaglandins (separated by extraction and sequential silicic acid, thin-layer and paper chromatography) [25].
  • The enzyme was selectively precipitated from the supernatant fraction with 45% acetone, resuspended in a 100 mM triethanolamine acetate buffer, pH 7.6, and ultimately purified by Bio-Sil TSK-400 gel filtration chromatography [26].
  • A cholesterol-deficient growth medium for human skin fibroblasts was prepared by adding to Eagle's Minimum Essential Medium a bovine serum treated with ultracentrifugation to remove bulk lipoproteins followed by silicic acid adsorption to remove residual lipoproteins and cholesterol [27].
  • In Step 1, a short gravity-flow silicic acid column (1.2 x 6.5 cm) separates the incubation products into four classes consisting of A) squalene + squalene oxide, B) methyl sterol precursors, C) C27 sterols, and D) polar compounds [28].
 

Gene context of SILICIC ACID

 

Analytical, diagnostic and therapeutic context of SILICIC ACID

References

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  2. Characterization of a structural series of lipid A obtained from the lipopolysaccharides of Neisseria gonorrhoeae. Combined laser desorption and fast atom bombardment mass spectral analysis of high performance liquid chromatography-purified dimethyl derivatives. Takayama, K., Qureshi, N., Hyver, K., Honovich, J., Cotter, R.J., Mascagni, P., Schneider, H. J. Biol. Chem. (1986) [Pubmed]
  3. alpha-L-Fucopyranosylceramide, a novel glycolipid accumulated in some of the human colon tumors. Watanabe, K., Matsubara, T., Hakomori, S. J. Biol. Chem. (1976) [Pubmed]
  4. Preparation of radiolabeled GM2 and GA2 gangliosides. Novak, A., Lowden, J.A., Gravel, Y.L., Wolfe, L.S. J. Lipid Res. (1979) [Pubmed]
  5. Silica gel as transport medium for Corynebacterium diphtheriae under tropical conditions (Indonesia ). Kim-Farley, R.J., Soewarso, T.I., Rejeki, S., Soeharto, n.u.l.l., Karyadi, A., Nurhayati, S., Soeharto, S. J. Clin. Microbiol. (1987) [Pubmed]
  6. Further thoughts on the aluminum-Alzheimer's disease link. Forbes, W.F., McLachlan, D.R. Journal of epidemiology and community health. (1996) [Pubmed]
  7. Supplementation of the diet with silicic acid to reduce body burden of aluminum: A miracle cure or useless treatment for Alzheimer's disease? Savory, J., Herman, M.M., Ghribi, O. J. Alzheimers Dis. (2006) [Pubmed]
  8. Polycationic peptides from diatom biosilica that direct silica nanosphere formation. Kröger, N., Deutzmann, R., Sumper, M. Science (1999) [Pubmed]
  9. Interrelationships of human interferon-gamma with lymphotoxin and monocyte cytotoxin. Stone-Wolff, D.S., Yip, Y.K., Kelker, H.C., Le, J., Henriksen-Destefano, D., Rubin, B.Y., Rinderknecht, E., Aggarwal, B.B., Vilcek, J. J. Exp. Med. (1984) [Pubmed]
  10. A ganglioside antigen on the rat pancreatic B cell surface identified by monoclonal antibody R2D6. Alejandro, R., Shienvold, F.L., Hajek, S.A., Pierce, M., Paul, R., Mintz, D.H. J. Clin. Invest. (1984) [Pubmed]
  11. Purification and biochemical properties of a human monocyte-derived growth factor. Singh, J.P., Bonin, P.D. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  12. Mono-sulfated globopentaosylceramide from human kidney. Nagai, K., Roberts, D.D., Toida, T., Matsumoto, H., Kushi, Y., Handa, S., Ishizuka, I. J. Biol. Chem. (1989) [Pubmed]
  13. Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. Reffitt, D.M., Jugdaohsingh, R., Thompson, R.P., Powell, J.J. J. Inorg. Biochem. (1999) [Pubmed]
  14. Chemotactic lipoxygenase products in sera from patients with psoriasis. Fogh, K., Ternowitz, T., Kragballe, K., Herlin, T. Arch. Dermatol. Res. (1986) [Pubmed]
  15. Release of slow reacting substance of anaphylaxis (SRS-A) from human leukocytes by the calcium ionophore A23187. Conroy, M.C., Orange, R.P., Lichtenstein, L.M. J. Immunol. (1976) [Pubmed]
  16. Cholesterol synthesis in rat liver peroxisomes. Conversion of mevalonic acid to cholesterol. Thompson, S.L., Burrows, R., Laub, R.J., Krisans, S.K. J. Biol. Chem. (1987) [Pubmed]
  17. Inspired by nature: an exploration of biocatalyzed siloxane bond formation and cleavage. Brandstadt, K.F. Curr. Opin. Biotechnol. (2005) [Pubmed]
  18. Simple procedure for the removal of nonspecific inhibitors of rubella virus hemagglutination. Allen, R., Hedlund, K. J. Clin. Microbiol. (1975) [Pubmed]
  19. Purification of ovine placental lactogen (oPL) using high-performance liquid chromatography. Evidence for two forms of oPL. Chan, J.S., Nie, Z.R., Seidah, N.G., Chrétien, M. FEBS Lett. (1986) [Pubmed]
  20. Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds. Borgeat, P., Samuelsson, B. J. Biol. Chem. (1979) [Pubmed]
  21. Occurrence of an endogenous inhibitor of platelet-activating factor in rat liver. Miwa, M., Hill, C., Kumar, R., Sugatani, J., Olson, M.S., Hanahan, D.J. J. Biol. Chem. (1987) [Pubmed]
  22. Rotational relaxation times of 1,6-diphenyl-1,3,5-hexatriene in phospholipids isolated from LM cell membranes. Effects of phospholipid polar head-group and fatty acid composition. Gilmore, R., Cohn, N., Glaser, M. Biochemistry (1979) [Pubmed]
  23. The uptake of silicic acid by rat liver mitochondria. Johnson, R.N., Volcani, B.E. Biochem. J. (1978) [Pubmed]
  24. Purification and properties of sterol carrier protein1. Srikantaiah, M.V., Hansbury, E., Loughran, E.D., Scallen, T.J. J. Biol. Chem. (1976) [Pubmed]
  25. Endogenous prostaglandin synthesis and glucose-induced insulin secretion from the adult rat pancreatic islet. Evans, M.H., Pace, C.S., Clements, R.S. Diabetes (1983) [Pubmed]
  26. Purification and characterization of guanosine diphospho-D-mannose dehydrogenase. A key enzyme in the biosynthesis of alginate by Pseudomonas aeruginosa. Roychoudhury, S., May, T.B., Gill, J.F., Singh, S.K., Feingold, D.S., Chakrabarty, A.M. J. Biol. Chem. (1989) [Pubmed]
  27. Effect of cholesterol and growth factors on the proliferation of cultured human skin fibroblasts. Ostlund, R.E., Yang, J.W. Exp. Cell Res. (1985) [Pubmed]
  28. The separation of sterol intermediates in cholesterol biosynthesis by high pressure liquid chromatography. Hansbury, E., Scallen, T.J. J. Lipid Res. (1980) [Pubmed]
  29. A sensitive radioimmunoassay for alpha-interferon: circulating alpha-interferon-like substance in the plasma of healthy individuals and rheumatoid arthritis patients. Shiozawa, S., Chihara, K., Shiozawa, K., Fujita, T., Ikegami, H., Koyama, S., Kurimoto, M. Clin. Exp. Immunol. (1986) [Pubmed]
  30. Purification of granulocyte chemotactic peptide/interleukin-8 reveals N-terminal sequence heterogeneity similar to that of beta-thromboglobulin. Van Damme, J., Van Beeumen, J., Conings, R., Decock, B., Billiau, A. Eur. J. Biochem. (1989) [Pubmed]
  31. Expression of a human mutant monocyte chemotactic protein 3 in Pichia pastoris and characterization as an MCP-3 receptor antagonist. Masure, S., Paemen, L., Proost, P., Van Damme, J., Opdenakker, G. J. Interferon Cytokine Res. (1995) [Pubmed]
  32. Impaired beta-endorphin response to human corticotropin-releasing hormone in obese children. Bernasconi, S., Petraglia, F., Iughetti, L., Marcellini, C., Lamborghini, A., Facchinetti, F., Genazzani, A.R. Acta Endocrinol. (1988) [Pubmed]
  33. Characterization of the major neutrophil-stimulating activity present in culture medium conditioned by Staphylococcus aureus-stimulated mononuclear leucocytes. Bates, E.J., Ferrante, A., Beard, L.J. Immunology (1991) [Pubmed]
  34. Release of a slow-reacting substance from rabbit platelets. Mencia-Huerta, J.M., Hadji, L., Benveniste, J. J. Clin. Invest. (1981) [Pubmed]
  35. Oxidation of leukotrienes at the omega end: demonstration of a receptor for the 20-hydroxy derivative of leukotriene B4 on human neutrophils and implications for the analysis of leukotriene receptors. Clancy, R.M., Dahinden, C.A., Hugli, T.E. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  36. Effects of diuretic and propranolol on plasma lipoprotein lipids. Bauer, J.H., Brooks, C.S., Weinstein, I., Wilcox, H.H., Heimberg, M., Burch, R.N., Barkley, R. Clin. Pharmacol. Ther. (1981) [Pubmed]
  37. Conversion of phospholipids to free fatty acids in response to acquisition of polymyxin resistance in Pseudomonas aeruginosa. Champlin, F.R., Gilleland, H.E., Conrad, R.S. Antimicrob. Agents Chemother. (1983) [Pubmed]
 
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