The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Cubosic     dihydroxy-oxo-silane

Synonyms: Mikronisil, Kieselsaure, oxosilanediol, H-Ilerit, Bio-Sil, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SILICIC ACID


Psychiatry related information on SILICIC ACID

  • The relationship between dementia and Al concentrations was U or J shaped--there was a minimum at an Al concentration of 100 micrograms/l. Other constituents or properties such as silicic acid, fluoride, turbidity, iron, and pH all have an effect on the relationship [6].
  • Supplementation of the diet with silicic acid to reduce body burden of aluminum: A miracle cure or useless treatment for Alzheimer's disease [7]?

High impact information on SILICIC ACID

  • A set of polycationic peptides (called silaffins) isolated from diatom cell walls were shown to generate networks of silica nanospheres within seconds when added to a solution of silicic acid [8].
  • Processing of conditioned media by sequential chromatography on silicic acid, Con A-Sepharose, and DEAE-Sephacel failed to separate IFN-gamma from the LT activity [9].
  • The antigen bound to DEAE-Sephacel, was not inactivated by mild treatment with base (which hydrolyzes phospholipids) and eluted in ganglioside fractions upon C18 Sep-Pak and upon silicic acid chromatography [10].
  • A monocyte-derived growth factor (MDGF) that stimulates proliferation of fibroblast and smooth muscle cells was purified from mitogen-stimulated human peripheral blood lymphocyte conditioned medium by using anion-exchange, Bio-Sil TSK-250 HPLC gel-permeation chromatography, and NaDodSO4/PAGE [11].
  • This lipid was purified from a pooled kidney preparation by chloroform/methanol extraction, mild alkaline treatment, DEAE-Sephadex and silicic acid column chromatographies, and preparative thin layer chromatography [12].

Chemical compound and disease context of SILICIC ACID


Biological context of SILICIC ACID


Anatomical context of SILICIC ACID


Associations of SILICIC ACID with other chemical compounds

  • Lanosterol was identified by silicic acid chromatography and mass spectrometry [24].
  • Using 3H-arachidonic acid as a tracer, we evaluated the effect of glucose stimulation upon the incorporation of this fatty acid into islet phospholipids and prostaglandins (separated by extraction and sequential silicic acid, thin-layer and paper chromatography) [25].
  • The enzyme was selectively precipitated from the supernatant fraction with 45% acetone, resuspended in a 100 mM triethanolamine acetate buffer, pH 7.6, and ultimately purified by Bio-Sil TSK-400 gel filtration chromatography [26].
  • A cholesterol-deficient growth medium for human skin fibroblasts was prepared by adding to Eagle's Minimum Essential Medium a bovine serum treated with ultracentrifugation to remove bulk lipoproteins followed by silicic acid adsorption to remove residual lipoproteins and cholesterol [27].
  • In Step 1, a short gravity-flow silicic acid column (1.2 x 6.5 cm) separates the incubation products into four classes consisting of A) squalene + squalene oxide, B) methyl sterol precursors, C) C27 sterols, and D) polar compounds [28].

Gene context of SILICIC ACID


Analytical, diagnostic and therapeutic context of SILICIC ACID


  1. Monophosphoryl lipid A obtained from lipopolysaccharides of Salmonella minnesota R595. Purification of the dimethyl derivative by high performance liquid chromatography and complete structural determination. Qureshi, N., Mascagni, P., Ribi, E., Takayama, K. J. Biol. Chem. (1985) [Pubmed]
  2. Characterization of a structural series of lipid A obtained from the lipopolysaccharides of Neisseria gonorrhoeae. Combined laser desorption and fast atom bombardment mass spectral analysis of high performance liquid chromatography-purified dimethyl derivatives. Takayama, K., Qureshi, N., Hyver, K., Honovich, J., Cotter, R.J., Mascagni, P., Schneider, H. J. Biol. Chem. (1986) [Pubmed]
  3. alpha-L-Fucopyranosylceramide, a novel glycolipid accumulated in some of the human colon tumors. Watanabe, K., Matsubara, T., Hakomori, S. J. Biol. Chem. (1976) [Pubmed]
  4. Preparation of radiolabeled GM2 and GA2 gangliosides. Novak, A., Lowden, J.A., Gravel, Y.L., Wolfe, L.S. J. Lipid Res. (1979) [Pubmed]
  5. Silica gel as transport medium for Corynebacterium diphtheriae under tropical conditions (Indonesia ). Kim-Farley, R.J., Soewarso, T.I., Rejeki, S., Soeharto, n.u.l.l., Karyadi, A., Nurhayati, S., Soeharto, S. J. Clin. Microbiol. (1987) [Pubmed]
  6. Further thoughts on the aluminum-Alzheimer's disease link. Forbes, W.F., McLachlan, D.R. Journal of epidemiology and community health. (1996) [Pubmed]
  7. Supplementation of the diet with silicic acid to reduce body burden of aluminum: A miracle cure or useless treatment for Alzheimer's disease? Savory, J., Herman, M.M., Ghribi, O. J. Alzheimers Dis. (2006) [Pubmed]
  8. Polycationic peptides from diatom biosilica that direct silica nanosphere formation. Kröger, N., Deutzmann, R., Sumper, M. Science (1999) [Pubmed]
  9. Interrelationships of human interferon-gamma with lymphotoxin and monocyte cytotoxin. Stone-Wolff, D.S., Yip, Y.K., Kelker, H.C., Le, J., Henriksen-Destefano, D., Rubin, B.Y., Rinderknecht, E., Aggarwal, B.B., Vilcek, J. J. Exp. Med. (1984) [Pubmed]
  10. A ganglioside antigen on the rat pancreatic B cell surface identified by monoclonal antibody R2D6. Alejandro, R., Shienvold, F.L., Hajek, S.A., Pierce, M., Paul, R., Mintz, D.H. J. Clin. Invest. (1984) [Pubmed]
  11. Purification and biochemical properties of a human monocyte-derived growth factor. Singh, J.P., Bonin, P.D. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  12. Mono-sulfated globopentaosylceramide from human kidney. Nagai, K., Roberts, D.D., Toida, T., Matsumoto, H., Kushi, Y., Handa, S., Ishizuka, I. J. Biol. Chem. (1989) [Pubmed]
  13. Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. Reffitt, D.M., Jugdaohsingh, R., Thompson, R.P., Powell, J.J. J. Inorg. Biochem. (1999) [Pubmed]
  14. Chemotactic lipoxygenase products in sera from patients with psoriasis. Fogh, K., Ternowitz, T., Kragballe, K., Herlin, T. Arch. Dermatol. Res. (1986) [Pubmed]
  15. Release of slow reacting substance of anaphylaxis (SRS-A) from human leukocytes by the calcium ionophore A23187. Conroy, M.C., Orange, R.P., Lichtenstein, L.M. J. Immunol. (1976) [Pubmed]
  16. Cholesterol synthesis in rat liver peroxisomes. Conversion of mevalonic acid to cholesterol. Thompson, S.L., Burrows, R., Laub, R.J., Krisans, S.K. J. Biol. Chem. (1987) [Pubmed]
  17. Inspired by nature: an exploration of biocatalyzed siloxane bond formation and cleavage. Brandstadt, K.F. Curr. Opin. Biotechnol. (2005) [Pubmed]
  18. Simple procedure for the removal of nonspecific inhibitors of rubella virus hemagglutination. Allen, R., Hedlund, K. J. Clin. Microbiol. (1975) [Pubmed]
  19. Purification of ovine placental lactogen (oPL) using high-performance liquid chromatography. Evidence for two forms of oPL. Chan, J.S., Nie, Z.R., Seidah, N.G., Chrétien, M. FEBS Lett. (1986) [Pubmed]
  20. Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds. Borgeat, P., Samuelsson, B. J. Biol. Chem. (1979) [Pubmed]
  21. Occurrence of an endogenous inhibitor of platelet-activating factor in rat liver. Miwa, M., Hill, C., Kumar, R., Sugatani, J., Olson, M.S., Hanahan, D.J. J. Biol. Chem. (1987) [Pubmed]
  22. Rotational relaxation times of 1,6-diphenyl-1,3,5-hexatriene in phospholipids isolated from LM cell membranes. Effects of phospholipid polar head-group and fatty acid composition. Gilmore, R., Cohn, N., Glaser, M. Biochemistry (1979) [Pubmed]
  23. The uptake of silicic acid by rat liver mitochondria. Johnson, R.N., Volcani, B.E. Biochem. J. (1978) [Pubmed]
  24. Purification and properties of sterol carrier protein1. Srikantaiah, M.V., Hansbury, E., Loughran, E.D., Scallen, T.J. J. Biol. Chem. (1976) [Pubmed]
  25. Endogenous prostaglandin synthesis and glucose-induced insulin secretion from the adult rat pancreatic islet. Evans, M.H., Pace, C.S., Clements, R.S. Diabetes (1983) [Pubmed]
  26. Purification and characterization of guanosine diphospho-D-mannose dehydrogenase. A key enzyme in the biosynthesis of alginate by Pseudomonas aeruginosa. Roychoudhury, S., May, T.B., Gill, J.F., Singh, S.K., Feingold, D.S., Chakrabarty, A.M. J. Biol. Chem. (1989) [Pubmed]
  27. Effect of cholesterol and growth factors on the proliferation of cultured human skin fibroblasts. Ostlund, R.E., Yang, J.W. Exp. Cell Res. (1985) [Pubmed]
  28. The separation of sterol intermediates in cholesterol biosynthesis by high pressure liquid chromatography. Hansbury, E., Scallen, T.J. J. Lipid Res. (1980) [Pubmed]
  29. A sensitive radioimmunoassay for alpha-interferon: circulating alpha-interferon-like substance in the plasma of healthy individuals and rheumatoid arthritis patients. Shiozawa, S., Chihara, K., Shiozawa, K., Fujita, T., Ikegami, H., Koyama, S., Kurimoto, M. Clin. Exp. Immunol. (1986) [Pubmed]
  30. Purification of granulocyte chemotactic peptide/interleukin-8 reveals N-terminal sequence heterogeneity similar to that of beta-thromboglobulin. Van Damme, J., Van Beeumen, J., Conings, R., Decock, B., Billiau, A. Eur. J. Biochem. (1989) [Pubmed]
  31. Expression of a human mutant monocyte chemotactic protein 3 in Pichia pastoris and characterization as an MCP-3 receptor antagonist. Masure, S., Paemen, L., Proost, P., Van Damme, J., Opdenakker, G. J. Interferon Cytokine Res. (1995) [Pubmed]
  32. Impaired beta-endorphin response to human corticotropin-releasing hormone in obese children. Bernasconi, S., Petraglia, F., Iughetti, L., Marcellini, C., Lamborghini, A., Facchinetti, F., Genazzani, A.R. Acta Endocrinol. (1988) [Pubmed]
  33. Characterization of the major neutrophil-stimulating activity present in culture medium conditioned by Staphylococcus aureus-stimulated mononuclear leucocytes. Bates, E.J., Ferrante, A., Beard, L.J. Immunology (1991) [Pubmed]
  34. Release of a slow-reacting substance from rabbit platelets. Mencia-Huerta, J.M., Hadji, L., Benveniste, J. J. Clin. Invest. (1981) [Pubmed]
  35. Oxidation of leukotrienes at the omega end: demonstration of a receptor for the 20-hydroxy derivative of leukotriene B4 on human neutrophils and implications for the analysis of leukotriene receptors. Clancy, R.M., Dahinden, C.A., Hugli, T.E. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  36. Effects of diuretic and propranolol on plasma lipoprotein lipids. Bauer, J.H., Brooks, C.S., Weinstein, I., Wilcox, H.H., Heimberg, M., Burch, R.N., Barkley, R. Clin. Pharmacol. Ther. (1981) [Pubmed]
  37. Conversion of phospholipids to free fatty acids in response to acquisition of polymyxin resistance in Pseudomonas aeruginosa. Champlin, F.R., Gilleland, H.E., Conrad, R.S. Antimicrob. Agents Chemother. (1983) [Pubmed]
WikiGenes - Universities