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Chemical Compound Review:

HMDB05844 (Z)-7-[(1S,2S,3R)-3-hydroxy- 2-[(E,3S)-3...

Synonyms: SureCN14510009, LMFA03110003, LS-174182, AC1NR1RW, 8-Iso-PGE2, ...

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High impact information on 27415-25-4

Application of the isoprostane 8-iso-prostaglandin E2 (8-iso-PGE2) produced an increase in transepithelial anion secretion across monolayers of the human airway epithelial cell line Calu-3, measured as an increase in short circuit current (Isc) [1].
This increase in Isc was greater when 8-iso-PGE2 was applied to the basolateral rather than the apical face of the Calu-3 monolayers and was almost entirely abolished by the addition of diphenylamine-2-carboxylate, implicating the cystic fibrosis transmembrane conductance regulator Cl- channel in the response [1].
After six cerebrospinal fluid washouts of the cranial window, both 8-iso-PGF2 alpha- and 8-iso-PGE2-treated vessels remained slightly constricted, whereas the PGF2 alpha-treated vessels returned to control diameter [2].
Of these, 8-iso-PGF2 alpha produced the greatest vasoconstriction (34% +/- 2), followed by 8-iso-PGE2 (25% +/- 4) and PGF2 alpha (20% +/- 2) [2].
We conclude that 8-iso-PGE2 induces nonspecific airway smooth muscle hyperresponsiveness through a non-TP non-EP prostanoid receptor [3].

Biological context of 27415-25-4

Only at concentrations of 10(-5) M or greater did 8-iso-PGE2 induce human platelet aggregation [4].
8-Iso-PGE2 caused a concentration-dependent decrease in the right ventricular systolic pressure from 3 nmol kg-1 to 100 nmol kg-1 (n = 43, p < 0.05), but showed no other activity [5].

Anatomical context of 27415-25-4

The epithelium responded to 8-iso-PGE2 but not to 8-iso-PGF2alpha [6].
The results indicate that 8-iso-PGE2 induces a Cl- secretion, and the effects involve prostanoid EP and FP receptors but not TP receptors in the porcine small intestine [7].
The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathways [8].

Associations of 27415-25-4 with other chemical compounds

Augmentation of bovine airway smooth muscle responsiveness to carbachol, KCl, and histamine by the isoprostane 8-iso-PGE2 [3].
3. 8-Iso-PGE2 (0.1-20 microM) potentiated adenosine diphosphate-(ADP) induced platelet aggregation in both human and rabbit [9].

Gene context of 27415-25-4

8-Iso-PGE2 did not reverse KCl tone, suggesting that voltage-dependent Ca2+ influx and myosin light chain kinase are not suppressed by isoprostanes [10].
1. 8-Iso-PGE2 induced either reversible or irreversible aggregation of platelets in human platelet-rich plasma (PRP) or in the suspension of washed platelets (WP) [9].

References

Isoprostane-mediated secretion from human airway epithelial cells. Cowley, E.A. Mol. Pharmacol. (2003) [Pubmed]
Isoprostanes: free radical-generated prostaglandins with constrictor effects on cerebral arterioles. Hoffman, S.W., Moore, S., Ellis, E.F. Stroke (1997) [Pubmed]
Augmentation of bovine airway smooth muscle responsiveness to carbachol, KCl, and histamine by the isoprostane 8-iso-PGE2. Catalli, A., Janssen, L.J. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
Actions of the E2-isoprostane, 8-ISO-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: additional evidence for the existence of a unique isoprostane receptor. Longmire, A.W., Roberts, L.J., Morrow, J.D. Prostaglandins (1994) [Pubmed]
Effect of the isoprostanes, 8-iso prostaglandin E2 and 8-iso prostaglandin F2 alpha on the rabbit lung in vivo. Hill, A.A., Coleman, R.A., Taylor, G.W., Moore, K.P., Taylor, I.K. Prostaglandins (1997) [Pubmed]
Intestinal effects of isoprostanes: evidence for the involvement of prostanoid EP and TP receptors. Elmhurst, J.L., Betti, P.A., Rangachari, P.K. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
Effects of isoprostanes and prostanoids on porcine small intestine. Unmack, M.A., Rangachari, P.K., Skadhauge, E. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathways. Huber, J., Bochkov, V.N., Binder, B.R., Leitinger, N. Antioxid. Redox Signal. (2003) [Pubmed]
Modulatory effect of 8-iso-PGE2 on platelets. Kobzar, G., Mardla, V., Järving, I., Samel, N., Lõhmus, M. Gen. Pharmacol. (1997) [Pubmed]
Receptors and signaling pathway underlying relaxations to isoprostanes in canine and porcine airway smooth muscle. Catalli, A., Zhang, D., Janssen, L.J. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]

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