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Chemical Compound Review

AGN-PC-006D0X     7-[3,5-dihydroxy-2-(3- hydroxyoct-1...

Synonyms: AG-D-90714, AG-F-57274, SureCN1685222, ACMC-20n4t7, CTK0H0425, ...
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Disease relevance of Enzaprost F

  • Insulin further increased the rate of entry into the s phage stimulated by EGF and PGF2 alpha together, whereas hydrocortisone inhibited the stimulatory effect observed with either EGF or PGF2 alpha alone [1].
  • 2) Does blocking HSP-70 synthesis reverse the inhibition of hormone-sensitive steroidogenesis induced by heat stress and PGF2 alpha [2]?
  • Incubation of pulmonary and aortic vessels with NG-nitro-L-argine methyl ester (L-NAME, 10 microM) caused an increase in the response to KCl, PE, and PGF2 alpha in pulmonary vessels in Sepsis and Sham rats but not in Control rats.(ABSTRACT TRUNCATED AT 250 WORDS)[3]
  • These behavioral and electrophysiological data suggest that mechanical hyperalgesia induced by spinal administration of PGE2 and PGF2 is mediated mainly by changes in NS neurons [4].
  • Flow reduction after PGF2 alpha was significantly greater in human coronary arteries with stenoses greater than 50% (94(4)%) than in those with stenoses less than 25% (55(14)%) (p less than 0.05) [5].

High impact information on Enzaprost F


Chemical compound and disease context of Enzaprost F


Biological context of Enzaprost F


Anatomical context of Enzaprost F


Associations of Enzaprost F with other chemical compounds


Gene context of Enzaprost F

  • Steady state concentrations of mRNA encoding StAR (P < 0.05) were 36% and 25% of the control value 12 and 24 h after PGF2 alpha injection [16].
  • The mitogenic effects of PGF2 alpha as well as of 12-O-tetradecanoyl phorbol 13-acetate (TPA; activator of protein kinase C) but not those of insulin (acting via the insulin-like growth factor 1 receptor) were abolished by a low concentration (7.5 nM) of staurosporine (inhibitor of protein kinase C) [28].
  • Estrogen secreted by pig trophoblast between gestational days 11-13 and 15-25 increases endometrial receptors for prolactin and causes exocrine secretion of PGF into the uterine lumen to prevent luteolysis [29].
  • A functional role of PGF2 alpha could be attributed to the post-initiation stages of tumor development in initiated mouse skin, i.e. the conversion stage (stage I of tumor promotion) elicited by two TPA applications and the promotion stage (stage II of promotion) brought about repetitive RPA treatments [10].
  • When combined with such a brief period of PRL withdrawal, the PGF2 alpha treatment induced a very rapid, drastic and permanent fall in serum progesterone, equal to that induced by CB-154 alone, or by removing the pituitary transplant on day 21 [30].

Analytical, diagnostic and therapeutic context of Enzaprost F


  1. Two growth factors and two hormones regulate initiation of DNA synthesis in cultured mouse cells through different pathways of events. Jimenez de Asua, L., Richmond, K.M., Otto, A.M. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  2. Heat shock protein-70 induction mediates luteal regression in the rat. Khanna, A., Aten, R.F., Behrman, H.R. Mol. Endocrinol. (1995) [Pubmed]
  3. Vascular reactivity in sepsis: importance of controls and role of nitric oxide. Yaghi, A., Paterson, N.A., McCormack, D.G. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  4. Spinal administration of prostaglandin E(2) or prostaglandin F(2alpha) primarily produces mechanical hyperalgesia that is mediated by nociceptive specific spinal dorsal horn neurons. Turnbach, M.E., Spraggins, D.S., Randich, A. Pain (2002) [Pubmed]
  5. Effects of vasoconstrictor agents on flow rate of isolated epicardial coronary artery of humans with various degrees of atherosclerosis and of young pigs. Sakaino, N., Araki, H., Nishi, K., Kimura, T., Yasue, H. Cardiovasc. Res. (1988) [Pubmed]
  6. The effect of serum, EGF, PGF2 alpha and insulin on S6 phosphorylation and the initiation of protein and DNA synthesis. Thomas, G., Martin-Pérez, J., Siegmann, M., Otto, A.M. Cell (1982) [Pubmed]
  7. Mechanisms of Ca(2+)-independent contraction in single permeabilized ferret aorta cells. Katsuyama, H., Morgan, K.G. Circ. Res. (1993) [Pubmed]
  8. Changes in cerebrovascular prostaglandins and thromboxane as a function of systemic blood pressure. Cerebral blood flow autoregulation of the newborn. Chemtob, S., Beharry, K., Rex, J., Varma, D.R., Aranda, J.V. Circ. Res. (1990) [Pubmed]
  9. Prostaglandin production by phagocytic cells of the mouse thymic reticulum in culture and its modulation by indomethacin and corticosteroids. Homo-Delarche, F., Duval, D., Papiernik, M. J. Immunol. (1985) [Pubmed]
  10. Eicosanoids and multistage carcinogenesis in NMRI mouse skin: role of prostaglandins E and F in conversion (first stage of tumor promotion) and promotion (second stage of tumor promotion). Fürstenberger, G., Gross, M., Marks, F. Carcinogenesis (1989) [Pubmed]
  11. Intraocular pressure-reducing effect of PhXA41 in patients with increased eye pressure. A one-month study. Alm, A., Villumsen, J., Törnquist, P., Mandahl, A., Airaksinen, J., Tuulonen, A., Marsk, A., Resul, B., Stjernschantz, J. Ophthalmology (1993) [Pubmed]
  12. Response of human isolated bronchial and lung parenchymal strips to SRS-A and other mediators of asthmatic bronchospasm. Ghelani, A.M., Holroyde, M.C., Sheard, P. Br. J. Pharmacol. (1980) [Pubmed]
  13. Sepsis-associated renal vasoconstriction: potential targets for future therapy. Badr, K.F. Am. J. Kidney Dis. (1992) [Pubmed]
  14. Intravenous PGF2 alpha infusion does not enhance hypoxic pulmonary vasoconstriction during canine one-lung hypoxia. Chen, L., Miller, F.L., Malmkvist, G., Cooley, R., Marshall, C., Marshall, B.E. Anesthesiology (1988) [Pubmed]
  15. Corticotropin-releasing hormone-induced vasodilatation in the human fetal placental circulation. Clifton, V.L., Read, M.A., Leitch, I.M., Boura, A.L., Robinson, P.J., Smith, R. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  16. Hormonal regulation of messenger ribonucleic acid encoding steroidogenic acute regulatory protein in ovine corpora lutea. Juengel, J.L., Meberg, B.M., Turzillo, A.M., Nett, T.M., Niswender, G.D. Endocrinology (1995) [Pubmed]
  17. Pituitary content of gonadotropins and receptors for gonadotropin-releasing hormone (GnRH) and hypothalamic content of GnRH during the periovulatory period of the ewe. Crowder, M.E., Nett, T.M. Endocrinology (1984) [Pubmed]
  18. Induction of bronchial hypersensitivity: evidence for a role for prostaglandins. Walters, E.H., Parrish, R.W., Bevan, C., Smith, A.P. Thorax (1981) [Pubmed]
  19. The effects of hyperosmolar solutions on cerebral arterial smooth muscle. Sasaki, T., Kassell, N.F., Fujiwara, S., Torner, J.C., Spallone, A. Stroke (1986) [Pubmed]
  20. Contact-dependent intercellular communication of bovine luteal cells in culture. Redmer, D.A., Grazul-Bilska, A.T., Reynolds, L.P. Endocrinology (1991) [Pubmed]
  21. Effects of extracellular pH on agonist-induced vascular tone of the cat ophthalmociliary artery. Su, E.N., Yu, D.Y., Alder, V.A., Cringle, S.J. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  22. Studies on the mechanism controlling generation of superoxide radical in luteinized rat ovaries during regression. Sawada, M., Carlson, J.C. Endocrinology (1994) [Pubmed]
  23. Evidence that distinct neural pathways mediate parasympathetic contractions and relaxations of guinea-pig trachealis. Canning, B.J., Undem, B.J. J. Physiol. (Lond.) (1993) [Pubmed]
  24. Evidence for two distinct forms of fatty acid cyclooxygenase in brain. Lysz, T.W., Needleman, P. J. Neurochem. (1982) [Pubmed]
  25. Differential regulation of Ca2+ homeostasis in ovine large and small luteal cells. Martínez-Zaguilán, R., Wegner, J.A., Gillies, R.J., Hoyer, P.B. Endocrinology (1994) [Pubmed]
  26. Regulation of gonadotropin-releasing hormone (GnRH) receptor messenger ribonucleic acid and GnRH receptors during the early preovulatory period in the ewe. Turzillo, A.M., Campion, C.E., Clay, C.M., Nett, T.M. Endocrinology (1994) [Pubmed]
  27. Stimulation of phosphatidylcholine breakdown and diacylglycerol production by growth factors in Swiss-3T3 cells. Price, B.D., Morris, J.D., Hall, A. Biochem. J. (1989) [Pubmed]
  28. Mitogenic signaling by prostaglandins in chemically transformed mouse fibroblasts: comparison with phorbol esters and insulin. Fagot, D., Buquet-Fagot, C., Mester, J. Endocrinology (1993) [Pubmed]
  29. Placental interferons. Bazer, F.W., Spencer, T.E., Ott, T.L. Am. J. Reprod. Immunol. (1996) [Pubmed]
  30. A luteotrophic action of prolactin: suppression of intraluteal prostaglandin production or effect? Ueda, K., Ochiai, K., Rothchild, I. Endocrinology (1985) [Pubmed]
  31. Changes in hormone levels and gap junctions in the rat uterus during pregnancy and parturition. Puri, C.P., Garfield, R.E. Biol. Reprod. (1982) [Pubmed]
  32. F prostaglandins function as potent olfactory stimulants that comprise the postovulatory female sex pheromone in goldfish. Sorensen, P.W., Hara, T.J., Stacey, N.E., Goetz, F.W. Biol. Reprod. (1988) [Pubmed]
  33. A possible role of airway epithelium in modulating hyperresponsiveness. Aizawa, H., Miyazaki, N., Shigematsu, N., Tomooka, M. Br. J. Pharmacol. (1988) [Pubmed]
  34. Roles of leukotrienes in bovine corpus luteum regression: an in vivo microdialysis study. Blair, R.M., Saatman, R., Liou, S.S., Fortune, J.E., Hansel, W. Proc. Soc. Exp. Biol. Med. (1997) [Pubmed]
  35. Combined effects of NO inhalation and intravenous PGF2 alpha on pulmonary circulation and gas exchange in an ovine ARDS model. Kobayashi, H., Tanaka, N., Winkler, M., Zapol, W.M. Intensive care medicine. (1996) [Pubmed]
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