Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1NRD1K (1S,6R,8R,9R)-8-(6-amino-2H- purin-9-yl)-3...

Synonyms:

Edwards, E. et al., Sun, X.C. et al., Dames, P. et al., Galantino-Homer, H.L. et al., Chik, C.L. et al.

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Disease relevance of SP-ADENOSINE-3',5'-CYCLIC-MONOPHOSPHOROTHIOATE

Rp-adenosine 3',5'-cyclic monophosphorothioate (4.5 nmol, n = 6), a cAMP-dependent PKA inhibitor, had no effect on the cardiopulmonary reflex when microinjected into the NTS alone but when given before a microinjection of either 8-BrcAMP (n = 6) or 5-MeOT (n = 6) blocked the attenuating effect on the reflex-evoked bradycardia [1].

High impact information on SP-ADENOSINE-3',5'-CYCLIC-MONOPHOSPHOROTHIOATE

Fluorescence measurements of pH changes at the luminal surface of isolated glands demonstrate that cAMP, Sp-adenosine-3',5'-cyclic monophosphorothioate, or forskolin, similar to serotonin, cause V-ATPase-dependent luminal acidification [2].
The presence of a cyclic AMP antagonist, Rp-adenosine 3',5'-cyclic monophosphorothioate, blocked the inhibition by isoproterenol and PACAP [3].
The HCO(3)(-)-dependent increase in Cl(-) permeability was reduced 57% in the presence of 50 microM Rp-adenosine 3',5'-cyclic monophosphorothioate, and 86% by 50 microM 5-nitro-2-(3-phenylpropyl-amino)benzoic acid but unaffected by 200 microM apical H(2)DIDS [4].
In contrast, Rp-adenosine-3',5'-cyclic monophosphorothioate (Rp-cAMPS), a protein kinase A (PK-A) antagonist, blocked the capacitation-associated increases in protein tyrosine phosphorylation [5].

References

5-HT(4) receptors in nucleus tractus solitarii attenuate cardiopulmonary reflex in anesthetized rats. Edwards, E., Paton, J.F. Am. J. Physiol. (1999) [Pubmed]
cAMP regulates plasma membrane vacuolar-type H+-ATPase assembly and activity in blowfly salivary glands. Dames, P., Zimmermann, B., Schmidt, R., Rein, J., Voss, M., Schewe, B., Walz, B., Baumann, O. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Alpha 1D L-type Ca(2+)-channel currents: inhibition by a beta-adrenergic agonist and pituitary adenylate cyclase-activating polypeptide (PACAP) in rat pinealocytes. Chik, C.L., Liu, Q.Y., Li, B., Klein, D.C., Zylka, M., Kim, D.S., Chin, H., Karpinski, E., Ho, A.K. J. Neurochem. (1997) [Pubmed]
HCO(3)(-)-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium. Sun, X.C., Zhai, C.B., Cui, M., Chen, Y., Levin, L.R., Buck, J., Bonanno, J.A. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
Regulation of protein tyrosine phosphorylation during bovine sperm capacitation by a cyclic adenosine 3'5'-monophosphate-dependent pathway. Galantino-Homer, H.L., Visconti, P.E., Kopf, G.S. Biol. Reprod. (1997) [Pubmed]

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