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Gene Review

Adcyap1  -  adenylate cyclase activating polypeptide 1

Rattus norvegicus

Synonyms: PACAP, Pituitary adenylate cyclase-activating polypeptide
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Disease relevance of Adcyap1

  • PACAP effects on acid secretion were determined in fistula rats with or without neutralizing anti-somatostatin antibodies [1].
  • The fact that PACAP prevented ethanol toxicity even when added 2 h after alcohol exposure, suggests that selective PACAP agonists could have potential therapeutic value for the treatment of fetal alcohol syndrome [2].
  • In the C6 glioma cell-line, TTF-1 activates the PACAP promoter in a dose-dependent manner [3].
  • The effect of PACAP38 on inositol phosphate formation was significantly reduced by U-73122 and by pertussis toxin, indicating that activation of PACAP receptors causes stimulation of a phospholipase C through a pertussis toxin-sensitive G protein [4].
  • PACAP was demonstrated in nerve fibres in all compartments of the pancreas and in a subpopulation of intrapancreatic VIP-containing ganglion cells [5].

Psychiatry related information on Adcyap1

  • Moreover, injections of PACAP into the centre of the posterior PnO resulted in REM sleep enhancement which could last for up to 11 consecutive days [6].
  • The administration of PACAP (1 or 2 nmol) caused a dose-dependent increase in both spontaneous motor activity and rearing behavior in the rat [7].
  • We propose that modulation of brain PACAP signaling might represent a new opportunity in the treatment of bipolar disorder [8].
  • Water deprivation for 24 h and 48 h caused a significant increase in PACAP gene transcripts in the SFO, compared with euhydrated animals [9].
  • The action of pituitary adenylate cyclase activating polypeptide (PACAP) on passive avoidance learning. The role of transmitters [10].

High impact information on Adcyap1


Chemical compound and disease context of Adcyap1


Biological context of Adcyap1


Anatomical context of Adcyap1


Associations of Adcyap1 with chemical compounds


Physical interactions of Adcyap1


Co-localisations of Adcyap1


Regulatory relationships of Adcyap1


Other interactions of Adcyap1

  • The cAMP responses of these receptors generally correlated with the ability of VIP to compete for PACAP radioligand binding with the exceptions for some particular chimeras [21].
  • One of the actions of PACAP identified previously is to decrease FSHbeta messenger RNA (mRNA) levels [18].
  • Pretreatment with nifedipine (10 microM), an L-type Ca2+ channel blocker, reduced PACAP-evoked pancreastatin secretion by 50-60%, gastrin-evoked secretion by approximately 80% and abolished the response to Bay K 8644 [23].
  • Assignments of the genes for rat pituitary adenylate cyclase activating polypeptide (Adcyap1) and its receptor subtypes (Adcyap1r1, Adcyap1r2, and Adcyap1r3) [33].
  • Furthermore, in alphaT3-1 cells PACAP activation of the follistatin promoter appears to be via the cAMP-dependent protein kinase A pathway [18].

Analytical, diagnostic and therapeutic context of Adcyap1


  1. PACAP type I receptor activation regulates ECL cells and gastric acid secretion. Zeng, N., Athmann, C., Kang, T., Lyu, R.M., Walsh, J.H., Ohning, G.V., Sachs, G., Pisegna, J.R. J. Clin. Invest. (1999) [Pubmed]
  2. Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death. Vaudry, D., Rousselle, C., Basille, M., Falluel-Morel, A., Pamantung, T.F., Fontaine, M., Fournier, A., Vaudry, H., Gonzalez, B.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Regulation of pituitary adenylate cyclase-activating polypeptide gene transcription by TTF-1, a homeodomain-containing transcription factor. Kim, M.S., Hur, M.K., Son, Y.J., Park, J.I., Chun, S.Y., D'Elia, A.V., Damante, G., Cho, S., Kim, K., Lee, B.J. J. Biol. Chem. (2002) [Pubmed]
  4. Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates adenylyl cyclase and phospholipase C activity in rat cerebellar neuroblasts. Basille, M., Gonzalez, B.J., Desrues, L., Demas, M., Fournier, A., Vaudry, H. J. Neurochem. (1995) [Pubmed]
  5. Pituitary adenylate cyclase-activating polypeptide in intrinsic and extrinsic nerves of the rat pancreas. Hannibal, J., Fahrenkrug, J. Cell Tissue Res. (2000) [Pubmed]
  6. Long-term enhancement of REM sleep by the pituitary adenylyl cyclase-activating polypeptide (PACAP) in the pontine reticular formation of the rat. Ahnaou, A., Basille, M., Gonzalez, B., Vaudry, H., Hamon, M., Adrien, J., Bourgin, P. Eur. J. Neurosci. (1999) [Pubmed]
  7. Effects of intracerebroventricular administration of pituitary adenylate cyclase-activating polypeptide (PACAP) on the motor activity and reserpine-induced hypothermia in murines. Masuo, Y., Noguchi, J., Morita, S., Matsumoto, Y. Brain Res. (1995) [Pubmed]
  8. Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex. Brandish, P.E., Su, M., Holder, D.J., Hodor, P., Szumiloski, J., Kleinhanz, R.R., Forbes, J.E., McWhorter, M.E., Duenwald, S.J., Parrish, M.L., Na, S., Liu, Y., Phillips, R.L., Renger, J.J., Sankaranarayanan, S., Simon, A.J., Scolnick, E.M. Neuron (2005) [Pubmed]
  9. Water deprivation increases the expression of pituitary adenylate cyclase-activating polypeptide gene in the rat subfornical organ. Nomura, M., Ueta, Y., Larsen, P.J., Hannibal, J., Serino, R., Kabashima, N., Shibuya, I., Yamashita, H. Endocrinology (1997) [Pubmed]
  10. The action of pituitary adenylate cyclase activating polypeptide (PACAP) on passive avoidance learning. The role of transmitters. Telegdy, G., Kokavszky, K. Brain Res. (2000) [Pubmed]
  11. Differential signal transduction by five splice variants of the PACAP receptor. Spengler, D., Waeber, C., Pantaloni, C., Holsboer, F., Bockaert, J., Seeburg, P.H., Journot, L. Nature (1993) [Pubmed]
  12. PACAP is an anti-mitogenic signal in developing cerebral cortex. Suh, J., Lu, N., Nicot, A., Tatsuno, I., DiCicco-Bloom, E. Nat. Neurosci. (2001) [Pubmed]
  13. VIP and PACAP potentiation of nicotinic ACh-evoked currents in rat parasympathetic neurons is mediated by G-protein activation. Liu, D.M., Cuevas, J., Adams, D.J. Eur. J. Neurosci. (2000) [Pubmed]
  14. Stimulation of rat pancreatic tumoral AR4-2J cell proliferation by pituitary adenylate cyclase-activating peptide. Buscail, L., Cambillau, C., Seva, C., Scemama, J.L., De Neef, P., Robberecht, P., Christophe, J., Susini, C., Vaysse, N. Gastroenterology (1992) [Pubmed]
  15. PACAP-containing intrapineal nerve fibers originate predominantly in the trigeminal ganglion: a combined retrograde tracing- and immunohistochemical study of the rat. Møller, M., Baeres, F.M. Brain Res. (2003) [Pubmed]
  16. Pituitary adenylate cyclase activating-peptide and its receptor antagonists in development of acute pancreatitis in rats. Chen, Y.D., Zhou, Z.G., Wang, Z., Gao, H.K., Yan, W.W., Wang, C., Zhao, G.P., Peng, X.H. World J. Gastroenterol. (2005) [Pubmed]
  17. Pituitary adenylate cyclase-activating polypeptide modulates gastric enterochromaffin-like cell proliferation in rats. Läuffer, J.M., Modlin, I.M., Hinoue, T., Kidd, M., Zhang, T., Schmid, S.W., Tang, L.H. Gastroenterology (1999) [Pubmed]
  18. Evidence that pituitary adenylate cyclase activating polypeptide suppresses follicle-stimulating hormone-beta messenger ribonucleic acid levels by stimulating follistatin gene transcription. Winters, S.J., Dalkin, A.C., Tsujii, T. Endocrinology (1997) [Pubmed]
  19. Differential expression of the pituitary gonadotropin subunit genes during male rat sexual maturation: reciprocal relationship between hypothalamic pituitary adenylate cyclase-activating polypeptide and follicle-stimulating hormone beta expression. Moore, J.P., Wilson, L., Dalkin, A.C., Winters, S.J. Biol. Reprod. (2003) [Pubmed]
  20. Pituitary adenylate cyclase activating polypeptide messenger RNA in the paraventricular nucleus and anterior pituitary during the rat estrous cycle. Moore, J.P., Burger, L.L., Dalkin, A.C., Winters, S.J. Biol. Reprod. (2005) [Pubmed]
  21. Vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide receptor chimeras reveal domains that determine specificity of vasoactive intestinal polypeptide binding and activation. Hashimoto, H., Ogawa, N., Hagihara, N., Yamamoto, K., Imanishi, K., Nogi, H., Nishino, A., Fujita, T., Matsuda, T., Nagata, S., Baba, A. Mol. Pharmacol. (1997) [Pubmed]
  22. Pituitary adenylate cyclase-activating polypeptide activates K(ATP) current in rat atrial myocytes. Baron, A., Monnier, D., Roatti, A., Baertschi, A.J. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  23. Somatostatin, misoprostol and galanin inhibit gastrin- and PACAP-stimulated secretion of histamine and pancreastatin from ECL cells by blocking specific Ca2+ channels. Björkqvist, M., Bernsand, M., Eliasson, L., Håkanson, R., Lindström, E. Regul. Pept. (2005) [Pubmed]
  24. Effects of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis. Masuo, Y., Matsumoto, Y., Tokito, F., Tsuda, M., Fujino, M. Brain Res. (1993) [Pubmed]
  25. Pituitary adenylate-cyclase-activating polypeptide stimulates proto-oncogene expression and activates the AP-1 (c-Fos/c-Jun) transcription factor in AR4-2J pancreatic carcinoma cells. Schäfer, H., Zheng, J., Gundlach, F., Günther, R., Siegel, E.G., Fölsch, U.R., Schmidt, W.E. Eur. J. Biochem. (1996) [Pubmed]
  26. Reciprocal activity of longitudinal and circular muscle during intestinal peristaltic reflex. Grider, J.R. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  27. Time-dependent effects of the neuropeptide PACAP on catecholamine secretion : stimulation and desensitization. Taupenot, L., Mahata, M., Mahata, S.K., O'Connor, D.T. Hypertension (1999) [Pubmed]
  28. Pituitary adenylate cyclase activating polypeptide innervation of the rat female reproductive tract and the associated paracervical ganglia: effect of capsaicin. Fahrenkrug, J., Hannibal, J. Neuroscience (1996) [Pubmed]
  29. Present status of knowledge about the distribution and colocalization of PACAP in the forebrain. Köves, K., Görcs, T.J., Kausz, M., Arimura, A. Acta. Biol. Hung. (1994) [Pubmed]
  30. Effect of pituitary adenylate cyclase activating polypeptide on vasopressin-induced proliferation of aortic smooth muscle cells: comparison with vasoactive intestinal polypeptide. Oiso, Y., Kotoyori, J., Murase, T., Ito, Y., Kozawa, O. Biochem. Cell Biol. (1993) [Pubmed]
  31. Modulation of secretin release by neuropeptides in secretin-producing cells. Chang, C.H., Chey, W.Y., Erway, B., Coy, D.H., Chang, T.M. Am. J. Physiol. (1998) [Pubmed]
  32. Pituitary adenylate cyclase-activating polypeptide stimulates cardiodilatin/atrial natriuretic peptide (CDD/ANP-(99-126) secretion from cultured neonatal rat myocardiocytes. Bäsler, I., Kuhn, M., Müller, W., Forssmann, W.G. Eur. J. Pharmacol. (1995) [Pubmed]
  33. Assignments of the genes for rat pituitary adenylate cyclase activating polypeptide (Adcyap1) and its receptor subtypes (Adcyap1r1, Adcyap1r2, and Adcyap1r3). Cai, Y., Xin, X., Yamada, T., Muramatsu, Y., Szpirer, C., Matsumoto, K. Cytogenet. Cell Genet. (1995) [Pubmed]
  34. Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. Hashimoto, H., Ishihara, T., Shigemoto, R., Mori, K., Nagata, S. Neuron (1993) [Pubmed]
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