Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1NT1AR [5-acetyloxy-6-[2-(3,4...

Synonyms:

Deng, M. et al., Sheng, G. et al., Xiong, Q. et al.

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Disease relevance of Tubuloside B

CONCLUSION: Tubuloside B has the neuroprotective capacity to antagonize TNFalpha-induced apoptosis in SH-SY5Y cells and may be useful in treating some neurodegenerative diseases [1].

High impact information on Tubuloside B

These results strongly indicate that tubuloside B prevents MPP +-induced apoptosis and oxidative stress [2].
Simultaneous treatment with tubuloside B markedly attenuated MPP +-induced cytotoxicity, DNA fragmentation, and intracellular accumulation of ROS [2].
Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes [3].
The antiapoptotic action of tubuloside B was partially dependent on an anti-oxidative stress effects, maintain of mitochondria function, decrease of concentration of free intracellular calcium and inhibition of caspase-3 activity [1].

References

Protective effect of tubuloside B on TNFalpha-induced apoptosis in neuronal cells. Deng, M., Zhao, J.Y., Ju, X.D., Tu, P.F., Jiang, Y., Li, Z.B. Acta Pharmacol. Sin. (2004) [Pubmed]
Tubuloside B from Cistanche salsa rescues the PC12 neuronal cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis and oxidative stress. Sheng, G., Pu, X., Lei, L., Tu, P., Li, C. Planta Med. (2002) [Pubmed]
Hepatoprotective activity of phenylethanoids from Cistanche deserticola. Xiong, Q., Hase, K., Tezuka, Y., Tani, T., Namba, T., Kadota, S. Planta Med. (1998) [Pubmed]

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