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Chemical Compound Review:

Tefluthrin (2,3,5,6-tetrafluoro-4- methyl...

Synonyms: AGN-PC-007CDU, AC1L1GWI, 79538-32-2

Spencer, C.I. et al., Natarajan, A. et al., Nishimatsu, T. et al., Culliford, S.J. et al., Boetel, M.A. et al., et al.

Spencer, Sham, Boetel, Fuller, Evenson,

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Disease relevance of C10992

To investigate the possible cardiac toxicity of these agents, we have examined the effects of a type-1 pyrethroid, tefluthrin, on isolated rat ventricular myocytes [1].

High impact information on C10992

Mechanisms underlying the effects of the pyrethroid tefluthrin on action potential duration in isolated rat ventricular myocytes [1].
Tefluthrin modulates a novel anionic background conductance (I(AB)) in guinea-pig ventricular myocytes [2].
Effect of Cry3Bb transgenic corn and tefluthrin on the soil microbial community: biomass, activity, and diversity [3].
Cyfluthrin, tetramethrin, fenpropathrin, tefluthrin and bioallethrin all significantly inhibited volume-sensitive I- efflux from HeLa cells at 100 micro mol/L [4].
All of the tested pyrethroids; alpha-Cypermethrin, Tetramethrin and Tefluthrin, produced similar changes in the electrophysiological properties of the cardiac myocytes, namely reduced beating frequency and amplitude [5].

Biological context of C10992

In some action potentials, tefluthrin also activated early after-depolarizations (EADs) [1].
The combined use of tefluthrin with an entomopathogenic nematode may offer an integrated approach to increase the efficacy of entomopathogenic nematodes for insect control [6].

Associations of C10992 with other chemical compounds

In myocytes, tefluthrin (type I) and fenpropathrin and alpha-cypermethrin (type II) prolonged action potentials and evoked afterdepolarizations [7].

Gene context of C10992

Tefluthrin applications delayed onset, end, and time of maximum emergence of female D. barberi by 9.9, 14.1, and 12 d, respectively, during 1993 [8].

References

Mechanisms underlying the effects of the pyrethroid tefluthrin on action potential duration in isolated rat ventricular myocytes. Spencer, C.I., Sham, J.S. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
Tefluthrin modulates a novel anionic background conductance (I(AB)) in guinea-pig ventricular myocytes. Borg, J.J., Hancox, J.C., Spencer, C.I., Kozlowski, R.Z. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
Effect of Cry3Bb transgenic corn and tefluthrin on the soil microbial community: biomass, activity, and diversity. Devare, M.H., Jones, C.M., Thies, J.E. J. Environ. Qual. (2004) [Pubmed]
Differential effects of pyrethroids on volume-sensitive anion and organic osmolyte pathways. Culliford, S.J., Borg, J.J., O'Brien, M.J., Kozlowski, R.Z. Clin. Exp. Pharmacol. Physiol. (2004) [Pubmed]
Microelectrode array recordings of cardiac action potentials as a high throughput method to evaluate pesticide toxicity. Natarajan, A., Molnar, P., Sieverdes, K., Jamshidi, A., Hickman, J.J. Toxicology in vitro : an international journal published in association with BIBRA. (2006) [Pubmed]
Interaction of insecticides, entomopathogenic nematodes, and larvae of the western corn rootworm (Coleoptera: Chrysomelidae). Nishimatsu, T., Jackson, J.J. J. Econ. Entomol. (1998) [Pubmed]
Actions of pyrethroid insecticides on sodium currents, action potentials, and contractile rhythm in isolated mammalian ventricular myocytes and perfused hearts. Spencer, C.I., Yuill, K.H., Borg, J.J., Hancox, J.C., Kozlowski, R.Z. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
Emergence of adult northern and western corn rootworms (Coleoptera: Chrysomelidae) following reduced soil insecticide applications. Boetel, M.A., Fuller, B.W., Evenson, P.D. J. Econ. Entomol. (2003) [Pubmed]

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