Disease relevance of C10982

• To gain insights into the neurotoxicity of cyfluthrin, we compared and evaluated the toxicity profiles of chlorpyrifos and cyfluthrin in primary human fetal astrocytes [1].
• Cyfluthrin was evaluated in the field as a residual insecticide to develop a new strategy for control of Old World phlebotomine sand fly vectors of leishmaniasis, which live and rest inside termite mounds and animal burrows [2].
• We thus evaluated the efficacy of intra-domicile cyfluthrin spraying for the control of Triatoma dimidiata, the only Chagas disease vector in the Yucatán peninsula, Mexico, and monitored potential re-infestation every 15 days for up to 9 months [3].
• Field evaluation of cyfluthrin and malathion 96 TG ULV spraying at high-rise flats on dengue vectors in Malaysia [4].
• By the end of the trial, tick infestations increased on untreated cattle (311.7%) and cattle with pheromone tags (154.8%) but decreased on cattle with pheromone/ cyfluthrin (-45.0%), cyfluthrin (-42.8%), pheromone/deltamethrin (-68.7%) and deltamethrin tags (-87.6%) [5].

High impact information on C10982

• By using microarray gene expression profiling, we systematically identified and compared the potential molecular targets of chlorpyrifos and cyfluthrin, at a genome-wide scale [1].
• These results suggest that inflammatory activation of astrocytes might be an important mechanism underlying neurotoxicity of both chlorpyrifos and cyfluthrin [1].
• Area-wide acaricides can be highly effective in killing nymphal Ixodes scapularis, with >95% of nymphs killed in studies using cyfluthrin, deltamethrin, or carbaryl [6].
• An inhalation monitoring study found cyfluthrin air levels that approached experimentally established irritant thresholds for airborne cyfluthrin, from which a mean estimated absorbed dosage of 1.311 microg/kg/d was calculated [7].
• A total of 449 pregnant women were prospectively recruited at midgestation from an agricultural site in the Philippines where a preliminary survey indicated significant use at home and on the farm of the following compounds: propoxur, cyfluthrin, chlorpyrifos, cypermethrin, pretilachlor, bioallethrin, malathion, diazinon, and transfluthrin [8].

Chemical compound and disease context of C10982

• In cypermethrin or cyfluthrin, two of the eight isomers, 1R-cis-alphaS and 1R-trans-alphaS, contributed for almost all the toxicity in the racemate, while the other six enantiomers were inactive [9].
• In the residual toxicity test, cyfluthrin, dicrotophos, and oxamyl were highly toxic to N. viridula [10].
• For the susceptible strain, cyfluthrin and tetrachlorvinphos had similar toxicity to adults, but cyfluthrin was 5 times more toxic to larvae when compared with tetrachlorvinphos [11].
• Although some pyrethroids, such as cyfluthrin and lambda-cyhalothrin, are highly toxic to honey bees, the toxicity of tau-fluvalinate is low enough to warrant its use to control parasitic mites inside honey bee colonies [12].
• Susceptibility of the southern green stink bug, Nezara viridula (L.) (Heteroptera: Pentatomidae), and its endoparasitoid Trichopoda pennipes (F.) (Diptera: Tachinidae) to acetamiprid, cyfluthrin, dicrotophos, indoxacarb, oxamyl, and thiamethoxam was compared in residual and oral toxicity tests [10].

Biological context of C10982

• Human dose-excretion studies with the pyrethroid insecticide cyfluthrin: urinary metabolite profile following inhalation [13].
• A cyfluthrin elimination experiment showed that cyfluthrin metabolites are eliminated following first-order kinetics (t 1/2 = 6.4 h) [14].
• At LD50, cyfluthrin was the most toxic insecticide to adult males (0.53 microgram/g), adult females (1.2 micrograms/g), and gravid females (0.85 microgram/g) [15].
• Adulticidal effect of cyfluthrin against mosquitos of public health importance in Malaysia [16].
• The principal acaricide used for tick control was cyfluthrin (n = 21), with chlorpyrifos 2nd (n = 18), carbaryl 3rd (n = 12), and fluvalinate (n = 4) 4th [17].

Anatomical context of C10982

• We found that at the same concentrations, cyfluthrin exerts as great as, or greater toxic effects on the growth, survival, and proper functioning of human astrocytes [1].
• As a substrate for carboxylesterase activity, cyfluthrin was added to the lymphocyte suspension [18].

Associations of C10982 with other chemical compounds

• The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes [1].
• Isomer conversion occurred only at the alphaC in CP or CF, causing the analyte stereoisomer to convert to an epimer [19].
• The study indicated that polymeric chiral stationary phases based on cellulose derivatives are the most appropriate for the stereoisomer separation of cis-Biphenthrin, Resmethrin and (1R)-Phenothrin, whereas multiple-interaction CSPs, like (S)-1-(alpha-naphthyl)-ethylamine/(S)-tert-leucine, are more selective for Cyfluthrin [20].
• Resistance to cyfluthrin and tetrachlorvinphos in the lesser mealworm, Alphitobius diaperinus, collected from the eastern United States [11].
• The effect of Metarhizium anisopliae (Metschnikoff) Sorokin strain ESC-1 alone and in combination with sublethal doses of commercial formulations of chlorpyrifos, propetamphos and cyfluthrin on mortality of CSMA strain of German cockroach, Blattella germanica (L.), was determined by conducting in vivo studies that included 3 bioassays [21].

Gene context of C10982

• Beta-cyfluthrin (OMS 3051), a new synthetic pyrethroid and one of the stereoisomers of cyfluthrin, was studied for insecticidal activity against eight mosquito species [22].
• One day after the application the cyfluthrin concentration increased significantly from 0.25 (T1) to 33.8 mg/kg house dust (T2) and up to 4.9 ng/m3 in PM [23].
• Fifty, 90, and 99% lethal doses were calculated for bendiocarb, cyfluthrin, DDT, malathion, permethrin, and resmethrin on Phlebotomus bergeroti, P. langeroni, P. papatasi. and P. sergenti [24].

Analytical, diagnostic and therapeutic context of C10982

• Separation and analysis of diastereomers and enantiomers of cypermethrin and cyfluthrin by gas chromatography [25].
• Experimental application of Hyalomma dromedarii pheromone-impregnated in cyfluthrin (pyrethroid) decoys on experimentally infested camels revealed efficacy rate of 85.33%, while the control group showed normal pattern of tick engorgement [26].
• Larval mortality was significantly increased in dung collected up to at least seven days after treatment with deltamethrin, alpha-cypermethrin and cyfluthrin [27].

References