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Chemical Compound Review

Bulldock     [cyano-(4-fluoro-3-phenoxy- phenyl)methyl]...

Synonyms: Baythroid, Responsar, Syfrutrin, CYFLUTHRIN, Cyfluthine, ...
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Disease relevance of C10982

  • To gain insights into the neurotoxicity of cyfluthrin, we compared and evaluated the toxicity profiles of chlorpyrifos and cyfluthrin in primary human fetal astrocytes [1].
  • Cyfluthrin was evaluated in the field as a residual insecticide to develop a new strategy for control of Old World phlebotomine sand fly vectors of leishmaniasis, which live and rest inside termite mounds and animal burrows [2].
  • We thus evaluated the efficacy of intra-domicile cyfluthrin spraying for the control of Triatoma dimidiata, the only Chagas disease vector in the Yucatán peninsula, Mexico, and monitored potential re-infestation every 15 days for up to 9 months [3].
  • Field evaluation of cyfluthrin and malathion 96 TG ULV spraying at high-rise flats on dengue vectors in Malaysia [4].
  • By the end of the trial, tick infestations increased on untreated cattle (311.7%) and cattle with pheromone tags (154.8%) but decreased on cattle with pheromone/ cyfluthrin (-45.0%), cyfluthrin (-42.8%), pheromone/deltamethrin (-68.7%) and deltamethrin tags (-87.6%) [5].

High impact information on C10982


Chemical compound and disease context of C10982


Biological context of C10982


Anatomical context of C10982

  • We found that at the same concentrations, cyfluthrin exerts as great as, or greater toxic effects on the growth, survival, and proper functioning of human astrocytes [1].
  • As a substrate for carboxylesterase activity, cyfluthrin was added to the lymphocyte suspension [18].

Associations of C10982 with other chemical compounds

  • The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes [1].
  • Isomer conversion occurred only at the alphaC in CP or CF, causing the analyte stereoisomer to convert to an epimer [19].
  • The study indicated that polymeric chiral stationary phases based on cellulose derivatives are the most appropriate for the stereoisomer separation of cis-Biphenthrin, Resmethrin and (1R)-Phenothrin, whereas multiple-interaction CSPs, like (S)-1-(alpha-naphthyl)-ethylamine/(S)-tert-leucine, are more selective for Cyfluthrin [20].
  • Resistance to cyfluthrin and tetrachlorvinphos in the lesser mealworm, Alphitobius diaperinus, collected from the eastern United States [11].
  • The effect of Metarhizium anisopliae (Metschnikoff) Sorokin strain ESC-1 alone and in combination with sublethal doses of commercial formulations of chlorpyrifos, propetamphos and cyfluthrin on mortality of CSMA strain of German cockroach, Blattella germanica (L.), was determined by conducting in vivo studies that included 3 bioassays [21].

Gene context of C10982


Analytical, diagnostic and therapeutic context of C10982


  1. The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes. Mense, S.M., Sengupta, A., Lan, C., Zhou, M., Bentsman, G., Volsky, D.J., Whyatt, R.M., Perera, F.P., Zhang, L. Toxicol. Sci. (2006) [Pubmed]
  2. Phlebotomine sand fly (Diptera: Psychodidae) control using a residual pyrethroid insecticide. Robert, L.L., Perich, M.J. J. Am. Mosq. Control Assoc. (1995) [Pubmed]
  3. Re-infestation of houses by Triatoma dimidiata after intra-domicile insecticide application in the Yucatán peninsula, Mexico. Dumonteil, E., Ruiz-Piña, H., Rodriguez-Félix, E., Barrera-Pérez, M., Ramirez-Sierra, M.J., Rabinovich, J.E., Menu, F. Mem. Inst. Oswaldo Cruz (2004) [Pubmed]
  4. Field evaluation of cyfluthrin and malathion 96 TG ULV spraying at high-rise flats on dengue vectors in Malaysia. Sulaiman, S., Pawanchee, Z.A., Othman, H.F., Jamal, J., Wahab, A., Sohadi, A.R., Rahman, A.R., Pandak, A. J. Vector Ecol. (1998) [Pubmed]
  5. Efficacy of tags impregnated with pheromone and acaricide for control of Amblyomma variegatum. Allan, S.A., Barré, N., Sonenshine, D.E., Burridge, M.J. Med. Vet. Entomol. (1998) [Pubmed]
  6. Strategies for reducing the risk of Lyme borreliosis in North America. Piesman, J. Int. J. Med. Microbiol. (2006) [Pubmed]
  7. Pyrethroid illnesses in California, 1996-2002. Spencer, J., O'Malley, M. Reviews of environmental contamination and toxicology. (2006) [Pubmed]
  8. Maternal hair--an appropriate matrix for detecting maternal exposure to pesticides during pregnancy. Ostrea, E.M., Villanueva-Uy, E., Bielawski, D.M., Posecion, N.C., Corrion, M.L., Jin, Y., Janisse, J.J., Ager, J.W. Environmental research. (2006) [Pubmed]
  9. Separation and aquatic toxicity of enantiomers of synthetic pyrethroid insecticides. Liu, W., Gan, J.J., Qin, S. Chirality. (2005) [Pubmed]
  10. Susceptibility of pest Nezara viridula (Heteroptera: Pentatomidae) and parasitoid Trichopoda pennipes (Diptera: Tachinidae) to selected insecticides. Tillman, P.G. J. Econ. Entomol. (2006) [Pubmed]
  11. Resistance to cyfluthrin and tetrachlorvinphos in the lesser mealworm, Alphitobius diaperinus, collected from the eastern United States. Hamm, R.L., Kaufman, P.E., Reasor, C.A., Rutz, D.A., Scott, J.G. Pest Manag. Sci. (2006) [Pubmed]
  12. Mediation of pyrethroid insecticide toxicity to honey bees (Hymenoptera: Apidae) by cytochrome P450 monooxygenases. Johnson, R.M., Wen, Z., Schuler, M.A., Berenbaum, M.R. J. Econ. Entomol. (2006) [Pubmed]
  13. Human dose-excretion studies with the pyrethroid insecticide cyfluthrin: urinary metabolite profile following inhalation. Leng, G., Leng, A., Kühn, K.H., Lewalter, J., Pauluhn, J. Xenobiotica (1997) [Pubmed]
  14. Biological monitoring of pyrethroids in blood and pyrethroid metabolites in urine: applications and limitations. Leng, G., Kühn, K.H., Idel, H. Sci. Total Environ. (1997) [Pubmed]
  15. Toxicity of several insecticide formulations against adult German cockroaches (Dictyoptera: Blattellidae). Abd-Elghafar, S.F., Appel, A.G., Mack, T.P. J. Econ. Entomol. (1990) [Pubmed]
  16. Adulticidal effect of cyfluthrin against mosquitos of public health importance in Malaysia. Vythilingam, I., Chiang, G.L., Amatachaya, C. Southeast Asian J. Trop. Med. Public Health (1992) [Pubmed]
  17. Pesticide use by licensed applicators for the control of Ixodes scapularis (Acari: Ixodidae) in Connecticut. Stafford, K.C. J. Med. Entomol. (1997) [Pubmed]
  18. The influence of individual susceptibility in pyrethroid exposure. Leng, G., Lewalter, J., Röhrig, B., Idel, H. Toxicol. Lett. (1999) [Pubmed]
  19. Chiral stability of synthetic pyrethroid insecticides. Liu, W., Qin, S., Gan, J. J. Agric. Food Chem. (2005) [Pubmed]
  20. A study on the separation of synthetic pyrethroid stereoisomers by HPLC. Girelli, A.M., Messina, A., Sinibaldi, M. Annali di chimica. (2002) [Pubmed]
  21. In vivo study on combined toxicity of Metarhizium anisopliae (Deuteromycotina: Hyphomycetes) strain ESC-1 with sublethal doses of chlorpyrifos, propetamphos, and cyfluthrin against German cockroach (Dictyoptera: Blattellidae). Pachamuthu, P., Kamble, S.T. J. Econ. Entomol. (2000) [Pubmed]
  22. Beta-cyfluthrin, a synthetic pyrethroid for mosquito control. Vasuki, V., Rajavel, A.R. Southeast Asian J. Trop. Med. Public Health (1992) [Pubmed]
  23. Pyrethroids used indoor-ambient monitoring of pyrethroids following a pest control operation. Leng, G., Berger-Preiss, E., Levsen, K., Ranft, U., Sugiri, D., Hadnagy, W., Idel, H. International journal of hygiene and environmental health. (2005) [Pubmed]
  24. Susceptibility of sand flies to selected insecticides in North Africa and the Middle East. Tetreault, G.E., Zayed, A.E., Hanafi, H.A., Beavers, G.M., Zeichner, B.C. J. Am. Mosq. Control Assoc. (2001) [Pubmed]
  25. Separation and analysis of diastereomers and enantiomers of cypermethrin and cyfluthrin by gas chromatography. Liu, W., Gan, J.J. J. Agric. Food Chem. (2004) [Pubmed]
  26. Trials for control of ixodid ticks using pheromone acaricide tick decoys. Abdel-Rahman, M.S., Fahmy, M.M., Aggour, M.G. Journal of the Egyptian Society of Parasitology. (1998) [Pubmed]
  27. Topical treatment of calves with synthetic pyrethroids: effects on the non-target dung fly Neomyia cornicina (Diptera: Muscidae). Sommer, C., Vagn Jensen, K.M., Jespersen, J.B. Bull. Entomol. Res. (2001) [Pubmed]
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