Disease relevance of ALLETHRIN

• When aged 5 months, they received bioallethrin (0.7 mg/kg body weight per day for 7 days) or paraoxon (1.4 mg/kg body weight every second day for 7 days). mRNA expression of subtypes m1, m3, and m4 was studied in 7-month-old animals [1].
• Effect of temperature on toxicity of a natural pyrethrin pesticide to green anole lizards (Anolis carolinensis) [2].
• While less severe allergic reactions have been reported, this is the first death associated with pyrethrin inhalation [3].
• Both cases were subsequently found to have infestations: one as a result of cutaneous larva migrans was successfully treated with ivermectin and the other caused by scabies mites was successfully treated with topical pyrethrin [4].
• Two hundred and sixty-eight children with pediculosis capitis took part in a comparative study to test the efficacy of five different pediculocides commonly used in Israel. The preparations used were pyrethrin shampoo, pyrethroid spray, malathion solution, carbaryl shampoo and carbaryl lotion [5].

Psychiatry related information on ALLETHRIN

• Twenty-four hours after the last administration, a spontaneous motor activity test revealed significant aberrations in mice exposed both neonatally and as adults to bioallethrin [6].

High impact information on ALLETHRIN

• In C. cinerariaefolium, CPP is an intermediate in the biosynthesis of the pyrethrin ester insecticides [7].
• The present study indicates that the earlier observed increase in muscarinic receptor density in mice exposed as neonates to DDT and as adults to bioallethrin can be attributed to changes in the expression of m4 [1].
• Permethrin had a noticeable effect on cell proliferation at 100 microM, whereas d-trans allethrin slightly induced MCF-7 cell proliferation at 10 microM, but was toxic at higher concentrations [8].
• At equi-toxic doses, S-bioallethrin extended the inter-stimulus interval evoking 50% inhibition in the hippocampus by 30+/-2.2 ms, and deltamethrin extended it by 199+/-21 ms [9].
• The effects of combined exposure to the pyrethroids deltamethrin and S-bioallethrin on hippocampal inhibition and skeletal muscle hyperexcitability in rats [9].

Chemical compound and disease context of ALLETHRIN

• In the present study, male NMRI mice were given bioallethrin (0.7 mg), deltamethrin (0.7 mg), or a 20% fat emulsion vehicle (10 ml) per kilogram of body weight per os once daily between the 10th and 16th postnatal day [10].
• To ascertain whether these changes were permanent, 10-day-old mice received an oral dose of DDT (0.5 mg/kg body weight) and at the age of 5 months they received bioallethrin orally (0.7 mg/kg body weight/day; 7 days) [11].
• Field evaluation of deltamethrin/S-bioallethrin/piperonyl butoxide and cyfluthrin against dengue vectors in Malaysia [12].

Biological context of ALLETHRIN

• This question was examined in rabbit ventricular myocytes by analyzing the kinetics of block of single sodium channel currents with normal gating kinetics or channels with inactivation and deactivation slowed by pyrethrin toxins [13].
• Here deltamethrin caused an increase and decrease in the percentage of high- and low-affinity binding sites, respectively, whereas the reverse was observed after bioallethrin treatment [14].
• Exposure of cells to the pyrethrin toxins deltamethrin or fenvalrate caused at least a tenfold increase in mean open time, and prominent tail currents could be recorded at the normal resting potential [13].
• Fatality associated with inhalation of a pyrethrin shampoo [3].
• Occupational exposure to synthetic pyrethrin insecticides on airliners was associated with neurobehavioral impairment and disability retirement [15].

Anatomical context of ALLETHRIN

• The inhibition of the lymphocyte proliferation by S-bioallethrin at the concentration 6.5 microM correlated well with the total serum IgE values (r = -0.89, P < 0.001) [16].
• Furthermore, S-bioallethrin induced histamine release from human basophils in a concentration-dependent manner [16].
• There was also a significant decrease and a tendency toward a decrease in the density of MAChR in the cerebral cortex in mice receiving bioallethrin and deltamethrin, respectively [10].
• Piperonyl butoxide potentiates the synaptosome ATPase inhibiting effect of pyrethrin [17].

Associations of ALLETHRIN with other chemical compounds

• Malathion and pyrethrin preparations seem equally effective against head lice [18].
• We recently reported changes in the density of muscarinic acetylcholine receptors in cerebral cortex of mice treated neonatally with DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane) and receiving bioallethrin as adults [11].
• The separation of the six pyrethrin esters in a technical pyrethrum extract (Riedel-de-Haën, Cresent Chemical Co. Inc. Hauppauge, NY, USA) by micellar electrokinetic chromatography (MEKC) using both sodium dodecyl sulfate (SDS) and a polymerized surfactant as pseudo-stationary phases has been investigated and optimized [19].
• The order of effectiveness from most to least effective was as follows: Ovide lotion, A-200 shampoo (a natural pyrethrin product synergized with piperonyl butoxide), undiluted Nix (1% permethrin), diluted Nix, RID (a natural pyrethrin product synergized with piperonyl butoxide), and 1% lindane shampoo [20].
• Significant changes in MAChR, assayed in the P2 fraction of the cerebral cortex by using the muscarinic antagonist, quinuclidinyl benzilate ([3H]QNB) and agonist carbachol, was only observed in animals receiving DDT as neonates and bioallethrin as adults [21].

Gene context of ALLETHRIN

• The non-estrogenic pyrethroids, d-trans allethrin and permethrin, demonstrated a similar elevation of WNT10B expression at a lower concentration, but not at the higher concentration [22].
• In the anti-estrogenic activity test, bioallethrin, fenvalerate, and permethrin significantly inhibited 17beta-estradiol-induced MCF-7 BUS cell proliferation at 10(-6) M, a concentration comparable to the effective dose (10(-9) M) of ICI 182,780, a pure ER antagonist [23].
• The regulatory interleukin-4/interferon-gamma (JL-4/IFN-gamma) balance showed a significant difference between atopic and nonatopic subjects after a short-term culture period (24 h) in the presence of the same concentration range of S-bioallethrin (P < 0.001) [16].
• Effect of sunscreen and antioxidant on the stability of pyrethrin formulations [24].
• We have observed that exposure to pesticides, such as DDT and bioallethrin, during the BGS in mice can potentiate susceptibility to bioallethrin or paraoxon in adult life [25].

Analytical, diagnostic and therapeutic context of ALLETHRIN

• GLC, HPLC and TLC chromatographic methods as the final determination of individual pyrethrin and pyrethroid residues and multi-residue, the enantiomer and diastereomer separation as well as the GC-MS confirmation are discussed and summarized in tabular form [26].
• Unlike fruit and vegetable extracts, soil and dust samples did not interfere with the ELISA, and the bioallethrin content in those samples could be determined with high precision without the need of any further purification [27].
• Determination of pyrethrin and pyrethroid pesticides in urine and water matrixes by liquid chromatography with diode array detection [28].
• Lesions cleared after treatments with malathion (dips) or pyrethrin (shampoos) [29].
• Stereoselectivity of a radioimmunoassay for the insecticide S-bioallethrin [30].

References