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Chemical Compound Review

ALLETHRIN     (2-methyl-4-oxo-3-prop-2- enyl-1-cyclopent...

Synonyms: Pyrocide, Exthrin, Pynamin, Pyresin, Pyresyn, ...
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Disease relevance of ALLETHRIN

  • When aged 5 months, they received bioallethrin (0.7 mg/kg body weight per day for 7 days) or paraoxon (1.4 mg/kg body weight every second day for 7 days). mRNA expression of subtypes m1, m3, and m4 was studied in 7-month-old animals [1].
  • Effect of temperature on toxicity of a natural pyrethrin pesticide to green anole lizards (Anolis carolinensis) [2].
  • While less severe allergic reactions have been reported, this is the first death associated with pyrethrin inhalation [3].
  • Both cases were subsequently found to have infestations: one as a result of cutaneous larva migrans was successfully treated with ivermectin and the other caused by scabies mites was successfully treated with topical pyrethrin [4].
  • Two hundred and sixty-eight children with pediculosis capitis took part in a comparative study to test the efficacy of five different pediculocides commonly used in Israel. The preparations used were pyrethrin shampoo, pyrethroid spray, malathion solution, carbaryl shampoo and carbaryl lotion [5].

Psychiatry related information on ALLETHRIN

  • Twenty-four hours after the last administration, a spontaneous motor activity test revealed significant aberrations in mice exposed both neonatally and as adults to bioallethrin [6].

High impact information on ALLETHRIN


Chemical compound and disease context of ALLETHRIN


Biological context of ALLETHRIN


Anatomical context of ALLETHRIN


Associations of ALLETHRIN with other chemical compounds


Gene context of ALLETHRIN


Analytical, diagnostic and therapeutic context of ALLETHRIN

  • GLC, HPLC and TLC chromatographic methods as the final determination of individual pyrethrin and pyrethroid residues and multi-residue, the enantiomer and diastereomer separation as well as the GC-MS confirmation are discussed and summarized in tabular form [26].
  • Unlike fruit and vegetable extracts, soil and dust samples did not interfere with the ELISA, and the bioallethrin content in those samples could be determined with high precision without the need of any further purification [27].
  • Determination of pyrethrin and pyrethroid pesticides in urine and water matrixes by liquid chromatography with diode array detection [28].
  • Lesions cleared after treatments with malathion (dips) or pyrethrin (shampoos) [29].
  • Stereoselectivity of a radioimmunoassay for the insecticide S-bioallethrin [30].


  1. Differential expression of muscarinic subtype mRNAs after exposure to neurotoxic pesticides. Talts, U., Talts, J.F., Eriksson, P. Neurobiol. Aging (1998) [Pubmed]
  2. Effect of temperature on toxicity of a natural pyrethrin pesticide to green anole lizards (Anolis carolinensis). Talent, L.G. Environ. Toxicol. Chem. (2005) [Pubmed]
  3. Fatality associated with inhalation of a pyrethrin shampoo. Wax, P.M., Hoffman, R.S. J. Toxicol. Clin. Toxicol. (1994) [Pubmed]
  4. Two cases of eosinophilic pustular folliculitis associated with parasitic infestations. Opie, K.M., Heenan, P.J., Delaney, T.A., Rohr, J.B. Australas. J. Dermatol. (2003) [Pubmed]
  5. Pediculosis capitis: why prefer a solution to shampoo or spray? Armoni, M., Bibi, H., Schlesinger, M., Pollak, S., Metzker, A. Pediatric dermatology. (1988) [Pubmed]
  6. Changes in behavior and muscarinic receptor density after neonatal and adult exposure to bioallethrin. Talts, U., Fredriksson, A., Eriksson, P. Neurobiol. Aging (1998) [Pubmed]
  7. Chrysanthemyl diphosphate synthase: isolation of the gene and characterization of the recombinant non-head-to-tail monoterpene synthase from Chrysanthemum cinerariaefolium. Rivera, S.B., Swedlund, B.D., King, G.J., Bell, R.N., Hussey, C.E., Shattuck-Eidens, D.M., Wrobel, W.M., Peiser, G.D., Poulter, C.D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  8. Estrogenic potential of certain pyrethroid compounds in the MCF-7 human breast carcinoma cell line. Go, V., Garey, J., Wolff, M.S., Pogo, B.G. Environ. Health Perspect. (1999) [Pubmed]
  9. The effects of combined exposure to the pyrethroids deltamethrin and S-bioallethrin on hippocampal inhibition and skeletal muscle hyperexcitability in rats. Ray, D.E., Burr, S.A., Lister, T. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  10. Neurotoxic effects of two different pyrethroids, bioallethrin and deltamethrin, on immature and adult mice: changes in behavioral and muscarinic receptor variables. Eriksson, P., Fredriksson, A. Toxicol. Appl. Pharmacol. (1991) [Pubmed]
  11. Bioallethrin causes permanent changes in behavioural and muscarinic acetylcholine receptor variables in adult mice exposed neonatally to DDT. Johansson, U., Fredriksson, A., Eriksson, P. Eur. J. Pharmacol. (1995) [Pubmed]
  12. Field evaluation of deltamethrin/S-bioallethrin/piperonyl butoxide and cyfluthrin against dengue vectors in Malaysia. Sulaiman, S., Pawanchee, Z.A., Othman, H.F., Jamal, J., Wahab, A., Sohadi, A.R., Pandak, A. J. Vector Ecol. (2000) [Pubmed]
  13. Kinetics of interaction of disopyramide with the cardiac sodium channel: fast dissociation from open channels at normal rest potentials. Grant, A.O., Wendt, D.J., Zilberter, Y., Starmer, C.F. J. Membr. Biol. (1993) [Pubmed]
  14. Effects of two pyrethroids, bioallethrin and deltamethrin, on subpopulations of muscarinic and nicotinic receptors in the neonatal mouse brain. Eriksson, P., Nordberg, A. Toxicol. Appl. Pharmacol. (1990) [Pubmed]
  15. Effects of onboard insecticide use on airline flight attendants. Kilburn, K.H. Arch. Environ. Health (2004) [Pubmed]
  16. In vitro effects of the pyrethroid S-bioallethrin on lymphocytes and basophils from atopic and nonatopic subjects. Diel, F., Detscher, M., Schock, B., Ennis, M. Allergy (1998) [Pubmed]
  17. Piperonyl butoxide potentiates the synaptosome ATPase inhibiting effect of pyrethrin. Kakko, I., Toimela, T., Tähti, H. Chemosphere (2000) [Pubmed]
  18. Treatment of scabies and pediculosis with lindane preparations: an evaluation. Shacter, B. J. Am. Acad. Dermatol. (1981) [Pubmed]
  19. Separation of natural pyrethrum extracts using micellar electrokinetic chromatography. Henry, C.W., Shamsi, S.A., Warner, I.M. Journal of chromatography. A. (1999) [Pubmed]
  20. Comparative in vitro pediculicidal efficacy of treatments in a resistant head lice population in the United States. Meinking, T.L., Serrano, L., Hard, B., Entzel, P., Lemard, G., Rivera, E., Villar, M.E. Archives of dermatology. (2002) [Pubmed]
  21. Neonatal exposure to DDT induces increased susceptibility to pyrethroid (bioallethrin) exposure at adult age.--Changes in cholinergic muscarinic receptor and behavioural variables. Eriksson, P., Johansson, U., Ahlbom, J., Fredriksson, A. Toxicology (1993) [Pubmed]
  22. Effects of pyrethroid insecticides and estrogen on WNT10B proto-oncogene expression. Kasat, K., Go, V., Pogo, B.G. Environment international. (2002) [Pubmed]
  23. Assessing estrogenic activity of pyrethroid insecticides using in vitro combination assays. Kim, I.Y., Shin, J.H., Kim, H.S., Lee, S.J., Kang, I.H., Kim, T.S., Moon, H.J., Choi, K.S., Moon, A., Han, S.Y. J. Reprod. Dev. (2004) [Pubmed]
  24. Effect of sunscreen and antioxidant on the stability of pyrethrin formulations. Minello, E.V., Lai, F., Zonchello, M.T., Melis, M., Russo, M., Cabras, P. J. Agric. Food Chem. (2005) [Pubmed]
  25. Neonatal exposure to neurotoxic pesticides increases adult susceptibility: a review of current findings. Eriksson, P., Talts, U. Neurotoxicology (2000) [Pubmed]
  26. Chromatographic methods for the determination of pyrethrin and pyrethroid pesticide residues in crops, foods and environmental samples. Chen, Z.M., Wang, Y.H. Journal of chromatography. A. (1996) [Pubmed]
  27. Enzyme-linked immunosorbent assay (ELISA) and sol-gel-based immunoaffinity purification (IAP) of the pyrethroid bioallethrin in food and environmental samples. Kaware, M., Bronshtein, A., Safi, J., Van Emon, J.M., Chuang, J.C., Hock, B., Kramer, K., Altstein, M. J. Agric. Food Chem. (2006) [Pubmed]
  28. Determination of pyrethrin and pyrethroid pesticides in urine and water matrixes by liquid chromatography with diode array detection. Loper, B.L., Anderson, K.A. Journal of AOAC International. (2003) [Pubmed]
  29. Dermatitis associated with Cheyletiella infestation in cats. McKeever, P.J., Allen, S.K. J. Am. Vet. Med. Assoc. (1979) [Pubmed]
  30. Stereoselectivity of a radioimmunoassay for the insecticide S-bioallethrin. Wing, K.D., Hammock, B.D. Experientia (1979) [Pubmed]
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