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Chemical Compound Review

Stannochlor     dichlorotin dihydrate

Synonyms: CCRIS 3953, LS-153845, AC1L1V86, D05918, 31669_RIEDEL, ...
 
 
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Disease relevance of dichlorotin dihydrate

 

High impact information on dichlorotin dihydrate

  • In conclusion, the protective effect of SnCl2 on K2Cr2O7-induced nephrotoxicity is associated with HO-1 induction and not with other antioxidant enzymes (Cu,Zn-SOD, Mn-SOD, GPx, GR, and CAT) and SnCl2 has a preventive and not a therapeutic effect on renal damage induced by K2Cr2O7 [3].
  • Genotoxic effects of stannous chloride (SnCl2) in K562 cell line [4].
  • In this study, plasmid desoxyribonucleic acid (DNA) was exposed to rutin (0.33, 10, 20, 30 microg/ml) in presence of stannous chloride (SnCl2), a reducing agent widely used to obtain radiopharmaceuticals labeled with technetium-99m [1].
  • The resting potential and the membrane resistance of the muscle fiber were not altered by 30 microM SnCl2 [5].
 

Gene context of dichlorotin dihydrate

  • The activity of Cu,Zn-SOD, Mn-SOD, GPx, CAT, and GR was unchanged in the SnCl2-treated rats [3].
  • It was found that the protective effect of SnCl2 on renal function was observed both at 24 and 48 h reaching its maximum at 24 h when HO-1 expression was higher [3].

References

  1. Biological effects of rutin on the survival of Escherichia coli AB1157 and on the electrophoretic mobility of plasmid PUC 9.1 DNA. Bernardo, L.C., de Oliveira, M.B., da Silva, C.R., Dantas, F.J., de Matros, J.C., Caldeira-de-Araújo, A., Moura, R.S., Bernardo-Filho, M. Cell. Mol. Biol. (Noisy-le-grand) (2002) [Pubmed]
  2. Induction of heme oxygenase produces load-independent cardioprotective effects in hypertensive rats. Seki, T., Naruse, M., Naruse, K., Yoshimoto, T., Tanabe, A., Seki, M., Tago, K., Imaki, T., Demura, R., Demura, H. Life Sci. (1999) [Pubmed]
  3. Protective effect of SnCl2 on K2Cr2O7-induced nephrotoxicity in rats: the indispensability of HO-1 preinduction and lack of association with some antioxidant enzymes. Barrera, D., Maldonado, P.D., Medina-Campos, O.N., Hernández-Pando, R., Ibarra-Rubio, M.E., Pedraza-Chaverrí, J. Life Sci. (2003) [Pubmed]
  4. Genotoxic effects of stannous chloride (SnCl2) in K562 cell line. Dantas, F.J., de Mattos, J.C., Moraes, M.O., Viana, M.E., Lage, C.A., Cabral-Neto, J.B., Leitão, A.C., Bernardo-Filho, M., Bezerraa, R.J., Carvalho, J.J., Caldeira-de-Araújo, A. Food Chem. Toxicol. (2002) [Pubmed]
  5. Anti-curare action of stannous ion in the frog neuromuscular junction. Hattori, T., Maehashi, H. Life Sci. (1988) [Pubmed]
 
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