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Chemical Compound Review

Dichlorotin     dichlorotin

Synonyms: SnCl2, Tin dichloride, CCRIS 560, HSDB 582, Tin salt, ...
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Disease relevance of dichlorotin


High impact information on dichlorotin


Chemical compound and disease context of dichlorotin


Biological context of dichlorotin

  • Stannous chloride catalyzed methylation of 4-pivaloxy-1-beta-D-ribofuranosyl-2-pyridinone (3c) gave the corresponding 2'-O-methyl derivative 6c [15].
  • Auto-redox reaction: tin(II) chloride-mediated one-step reductive cyclization leading to the synthesis of novel biheterocyclic 5,6-dihydro-quinazolino[4,3-b]quinazolin-8-ones with three-point diversity [16].
  • The effects of the reactive oxygen species scavenger ebselen and the HO inducers cobalt protoporphyrin and stannous chloride (SnCl(2)) on HO protein levels and activity, indices of oxidative stress, and the progression of diabetes were examined in the Zucker rat model of type 2 diabetes [17].
  • Tin(II) at concentrations up to 500 microM stannous chloride (SnCl2), produced extensive DNA damage, as detected by alkaline sucrose gradient (ASG) analysis in Chinese hamster ovary (CHO) cells treated for 1 h at 37 degrees C in serum-free minimal essential medium (MEM) [18].
  • In this study, male Wistar rats were stress conditioned with either stannous chloride or gallium nitrate, which have immunosuppressive effects in vivo and in vitro, or heat shock, the most intensively studied inducer of cytoprotection [19].

Anatomical context of dichlorotin


Associations of dichlorotin with other chemical compounds


Gene context of dichlorotin


Analytical, diagnostic and therapeutic context of dichlorotin


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  2. Effect of the Cymbopogon citratus, Maytenus ilicifolia and Baccharis genistelloides extracts against the stannous chloride oxidative damage in Escherichia coli. Melo, S.F., Soares, S.F., da Costa, R.F., da Silva, C.R., de Oliveira, M.B., Bezerra, R.J., Caldeira-de-Araújo, A., Bernardo-Filho, M. Mutat. Res. (2001) [Pubmed]
  3. Preoperative stress conditioning prevents paralysis after experimental aortic surgery: increased heat shock protein content is associated with ischemic tolerance of the spinal cord. Perdrizet, G.A., Lena, C.J., Shapiro, D.S., Rewinski, M.J. J. Thorac. Cardiovasc. Surg. (2002) [Pubmed]
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  5. Stannous and cuprous ion oxidation by Thiobacillus ferrooxidans. Lewis, A.J., Miller, J.D. Can. J. Microbiol. (1977) [Pubmed]
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  10. A closed eye contact lens model of corneal inflammation. Part 2: Inhibition of cytochrome P450 arachidonic acid metabolism alleviates inflammatory sequelae. Conners, M.S., Stoltz, R.A., Davis, K.L., Dunn, M.W., Abraham, N.G., Levere, R.D., Laniado-Schwartzman, M. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
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  12. Stannous chloride mediates single strand breaks in plasmid DNA through reactive oxygen species formation. Dantas, F.J., Moraes, M.O., de Mattos, J.C., Bezerra, R.J., Carvalho, E.F., Filho, M.B., Caldeira de Araújo, A. Toxicol. Lett. (1999) [Pubmed]
  13. 4-week oral toxicity study of a combination of eight chemicals in rats: comparison with the toxicity of the individual compounds. Jonker, D., Woutersen, R.A., van Bladeren, P.J., Til, H.P., Feron, V.J. Food Chem. Toxicol. (1990) [Pubmed]
  14. Comparison of technetium-99m pyrophosphate and technetium-99m methylene diphosphonate with variable amounts of stannous chloride in the detection of acute myocardial infarction. Huckell, V.F., Lyster, D.M., Morrison, R.T., Cooper, J.A. Clinical nuclear medicine. (1985) [Pubmed]
  15. Nucleic acid related compounds. 17.3-Deazuridine. Stannous chloride catalysis of cis-diol vs. phenolic base methylation with diazomethane. Robins, M.J., Lee, A.S. J. Med. Chem. (1975) [Pubmed]
  16. Auto-redox reaction: tin(II) chloride-mediated one-step reductive cyclization leading to the synthesis of novel biheterocyclic 5,6-dihydro-quinazolino[4,3-b]quinazolin-8-ones with three-point diversity. Roy, A.D., Subramanian, A., Roy, R. J. Org. Chem. (2006) [Pubmed]
  17. Up-Regulation of Heme Oxygenase Provides Vascular Protection in an Animal Model of Diabetes through Its Antioxidant and Antiapoptotic Effects. Kruger, A.L., Peterson, S.J., Schwartzman, M.L., Fusco, H., McClung, J.A., Weiss, M., Shenouda, S., Goodman, A.I., Goligorsky, M.S., Kappas, A., Abraham, N.G. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  18. The effect of stannous and stannic (tin) chloride on DNA in Chinese hamster ovary cells. McLean, J.R., Blakey, D.H., Douglas, G.R., Kaplan, J.G. Mutat. Res. (1983) [Pubmed]
  19. Effects of heat shock, stannous chloride, and gallium nitrate on the rat inflammatory response. House, S.D., Guidon, P.T., Perdrizet, G.A., Rewinski, M., Kyriakos, R., Bockman, R.S., Mistry, T., Gallagher, R.A., Hightower, L.E. Cell Stress Chaperones (2001) [Pubmed]
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  21. Effects of feeding stannous chloride on different parts of the gastrointestinal tract of the rat. Janssen, P.J., Bosland, M.C., van Hees, J.P., Spit, B.J., Willems, M.I., Kuper, C.F. Toxicol. Appl. Pharmacol. (1985) [Pubmed]
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  27. Stoichiometric Tc-99m RBC labeling using stable kit solutions of stannous chloride and EDTA: concise communication. Mock, B.H., Wellman, H.N. J. Nucl. Med. (1984) [Pubmed]
  28. Labeling a hydrazino nicotinamide-modified cyclic IIb/IIIa receptor antagonist with 99mTc using aminocarboxylates as coligands. Liu, S., Edwards, D.S., Looby, R.J., Harris, A.R., Poirier, M.J., Barrett, J.A., Heminway, S.J., Carroll, T.R. Bioconjug. Chem. (1996) [Pubmed]
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  31. Headspace gas-liquid chromatographic determination of dithiocarbamate residues in fruits and vegetables with confirmation by conversion to ethylenethiourea. Ahmad, N., Guo, L., Mandarakas, P., Farah, V., Appleby, S., Gibson, T. Journal of AOAC International. (1996) [Pubmed]
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  33. Effect of oxygen on the reduction of pertechnetate by stannous ion. Owunwanne, A., Church, L.B., Blau, M. J. Nucl. Med. (1977) [Pubmed]
  34. Determination of methylmercury and inorganic mercury in whole blood by headspace, cryofocusing gas chromatography and atomic absorption spectrometry. Brunetto, M.R., Luna, J.R., Zambrano, A., Gallignani, M., Burguera, M., Burguera, J.L., Petit de Peña, Y. The Analyst. (1999) [Pubmed]
  35. Radiopharmaceutical development of a freeze-dried kit formulation for the preparation of [99mTc-EDDA-HYNIC-D-Phe1, Tyr3]-octreotide, a somatostatin analog for tumor diagnosis. Guggenberg, E.V., Mikolajczak, R., Janota, B., Riccabona, G., Decristoforo, C. Journal of pharmaceutical sciences. (2004) [Pubmed]
  36. Benzidine-congener-based azo dyes: assays for purity and residues in feces from dosed rats. Levine, R.A., Oller, W.L., Nony, C.R., Bowman, M.C. Journal of analytical toxicology. (1982) [Pubmed]
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