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Chemical Compound Review:

Tradonal (1R,2R)-2- (dimethylaminomethyl)-1-(3...

Synonyms: Adolanta, Melanate, Synapryn, Contramal, Tramagetic, ...

This record was replaced with 33741.

Lintz, W. et al., Lintz, W. et al., Müller, B. et al., Richter, W. et al., Freye, E. et al., et al.

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High impact information on Tramadol

Thus, the mean AUC infinity of (+/-)tramadol obtained after multiple dosing were 4611 +/- 1944 and 5105 +/- 2101 ngh ml-1 after Topalgic 4 x 50mg and Tramadol LP 200 mg, respectively (95%CI 102-123%) [1].
Tramadol (CAS 36282-47-0) plays an important role in the management of pain [2].
As has been demonstrated in binding studies the two opioids tilidine (CAS 27107-79-7)/naloxone (CAS 357-08-4) and tramadol (CAS 36282-47-0) differ in regard to their affinities to the opioid receptor site [3].
Tramadol hydrochloride (CAS 36282-47-0) is a centrally acting analgesic agent binding to mu opiate receptors [4].
In a multicenter study 153 in- and outpatients suffering from severe pain were treated for three weeks with capsules containing 50 mg 1-(m-methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol (tramadol, Tramal) [5].

Biological context of Tramadol

In a balanced two-period cross-over study with 12 (6 male, 6 female) healthy young subjects the pharmacokinetics and absolute bioavailability of tramadol (tramadol hydrochloride, CAS 36282-47-0) after oral administration of Tramal drops (without ethanol) were to be determined in comparison with a 30-min i.v. infusion [6].
The pharmacokinetics and the absolute bioavailability of tramadol hydrochloride (CAS 36282-47-0) after oral administration of Tramal drops (with ethanol) were determined in a balanced cross-over study in 8 (4 male and 4 female) volunteers in comparison with the intravenous injection [7].

Anatomical context of Tramadol

Cardio-hemodynamic and direct cardiac effects of 1-(m-methoxyphenyl)-2-(dimethylaminomethyl)- cyclohexan -1-ol (tramadol, Tramal ), and pentazocine were investigated in anaesthetized rabbits and in isolated guinea-pig atria and papillary muscles [8].

References

Pharmacokinetic evaluation of a new oral sustained release dosage form of tramadol. Malonne, H., Sonet, B., Streel, B., Lebrun, S., De Niet, S., Sereno, A., Vanderbist, F. British journal of clinical pharmacology. (2004) [Pubmed]
Tramadol--the impact of its pharmacokinetic and pharmacodynamic properties on the clinical management of pain. Klotz, U. Arzneimittel-Forschung. (2003) [Pubmed]
Effects of tramadol and tilidine/naloxone on oral-caecal transit and pupillary light reflex. Freye, E., Latasch, L. Arzneimittel-Forschung. (2000) [Pubmed]
Bioequivalence study of tramadol by intramuscular administration in healthy volunteers. Chao, C.K., Yu, L.L., Su, L.L., Liu, C.M., Yang, T.H., Chen, C.M. Arzneimittel-Forschung. (2000) [Pubmed]
Clinical investigation on the development of dependence during oral therapy with tramadol. Richter, W., Barth, H., Flohé, L., Giertz, H. Arzneimittel-Forschung. (1985) [Pubmed]
Pharmacokinetics of tramadol and bioavailability of enteral tramadol formulations. 4th communication: drops (without ethanol). Lintz, W., Becker, R., Gerloff, J., Terlinden, R. Arzneimittel-Forschung. (2000) [Pubmed]
Pharmacokinetics of tramadol and bioavailability of enteral tramadol formulations. 2nd communication: drops with ethanol. Lintz, W., Barth, H., Becker, R., Frankus, E., Schmidt-Böthelt, E. Arzneimittel-Forschung. (1998) [Pubmed]
Cardiac and hemodynamic effects of the centrally acting analgesics tramadol and pentazocine in anaesthetized rabbits and isolated guinea-pig atria and papillary muscles. Müller, B., Wilsmann, K. Arzneimittel-Forschung. (1984) [Pubmed]

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