Disease relevance of Dichroin

• Recrudescence of the parasites after treatment with the febrifugine analogs was the key factor that caused the death of most of the mice in groups receiving an effective dose [1].
• Febrifugine significantly reduced the mortality and the level of parasitemia [2].
• Strong liver toxicity has precluded febrifugine as a potential clinical drug [3].

High impact information on Dichroin

• Febrifugine (1), a quinazoline alkaloid, isolated from Dichroa febrifuga roots, shows powerful antimalarial activity against Plasmodium falciparum [4].
• The host macrophages (J744 cells) were 50 to 100 times less sensitive to the febrifugine analogs than the parasites [1].
• Quinazolinone type alkaloids, febrifugine (1) and isofebrifugine (2), isolated from Dichroa febrifuga roots, show powerful antimalarial activity against Plasmodium falciparum [5].
• The plasma NO3- concentration began to rise within 2 days after treatment with febrifugine and declined to normal in 2 days when the mice were treated orally with febrifugine once a day for 3 consecutive days before parasite infection [2].
• Febrifugine was administered orally, at a dose of 1 mg/kg/day, to mice before and/or after they were infected intraperitoneally with 2 x 10(6) parasitized red blood cells [2].

Chemical compound and disease context of Dichroin

• A four-day dosage of 1 mg/kg of the febrifugine and isofebrifugine mixture alone showed a little antimalarial activity, but all mice died from day 19 to 27 with an increasing parasitemia [6].

Associations of Dichroin with other chemical compounds

• Thus, we have evaluated the in vitro antimalarial activity of the analogues of febrifugine (1) and isofebrifugine (2) [7].

Analytical, diagnostic and therapeutic context of Dichroin

• Febrifugine is the active principal isolated 50 years ago from the Chinese herb chang shan (Dichroa febrifuga Lour), which has been used as an antimalarial in Chinese traditional medicine for more than 2,000 years [1].

References