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Chemical Compound Review

Dichroin     3-[3-[(2S,3R)-3-hydroxy-2- piperidyl]-2-oxo...

Synonyms: Febrifugine, Ferbifrugin, b-dichroine, beta-Dichroine, CHEMBL479432, ...
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Disease relevance of Dichroin


High impact information on Dichroin


Chemical compound and disease context of Dichroin


Associations of Dichroin with other chemical compounds


Analytical, diagnostic and therapeutic context of Dichroin

  • Febrifugine is the active principal isolated 50 years ago from the Chinese herb chang shan (Dichroa febrifuga Lour), which has been used as an antimalarial in Chinese traditional medicine for more than 2,000 years [1].


  1. Antimalarial activities and therapeutic properties of febrifugine analogs. Jiang, S., Zeng, Q., Gettayacamin, M., Tungtaeng, A., Wannaying, S., Lim, A., Hansukjariya, P., Okunji, C.O., Zhu, S., Fang, D. Antimicrob. Agents Chemother. (2005) [Pubmed]
  2. Potentiation by febrifugine of host defense in mice against Plasmodium berghei NK65. Murata, K., Takano, F., Fushiya, S., Oshima, Y. Biochem. Pharmacol. (1999) [Pubmed]
  3. Synthesis and evaluation of febrifugine analogues as potential antimalarial agents. Zhu, S., Meng, L., Zhang, Q., Wei, L. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
  4. Exploration of a new type of antimalarial compounds based on febrifugine. Kikuchi, H., Yamamoto, K., Horoiwa, S., Hirai, S., Kasahara, R., Hariguchi, N., Matsumoto, M., Oshima, Y. J. Med. Chem. (2006) [Pubmed]
  5. Metabolites of febrifugine and its synthetic analogue by mouse liver S9 and their antimalarial activity against Plasmodium malaria parasite. Hirai, S., Kikuchi, H., Kim, H.S., Begum, K., Wataya, Y., Tasaka, H., Miyazawa, Y., Yamamoto, K., Oshima, Y. J. Med. Chem. (2003) [Pubmed]
  6. Combination effects of chloroquine with the febrifugine and isofebrifugine mixture against a blood-induced infection with chloroquine-resistant Plasmodium berghei NK65 in ICR mice. Ishih, A., Suzuki, T., Watanabe, M., Miyase, T., Terada, M. Phytotherapy research : PTR. (2003) [Pubmed]
  7. Potent antimalarial febrifugine analogues against the plasmodium malaria parasite. Kikuchi, H., Tasaka, H., Hirai, S., Takaya, Y., Iwabuchi, Y., Ooi, H., Hatakeyama, S., Kim, H.S., Wataya, Y., Oshima, Y. J. Med. Chem. (2002) [Pubmed]
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