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Chemical Compound Review

AC1LCVRC     diethyl (E)-but-2-enedioate

Synonyms: D95654_ALDRICH, AG-G-29076, ACN-S002054, HSDB 5722, NSC-20954, ...
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Disease relevance of DIETHYL MALEATE

  • To assess the effects of redox stress on inflammatory responses in endotoxemia, mice were treated with either diethyl maleate (DEM), a glutathione-depleting agent, or buthionine sulfoximine (BSO), an inhibitor of glutathione synthesis, and challenged with LPS [1].
  • OxoPrGSH was toxic when present for 24 hr, and this toxicity was also enhanced by pretreatment with DEM [2].

High impact information on DIETHYL MALEATE


Chemical compound and disease context of DIETHYL MALEATE


  1. Redox imbalance differentially inhibits lipopolysaccharide-induced macrophage activation in the mouse liver. Wang, F., Wang, L.Y., Wright, D., Parmely, M.J. Infect. Immun. (1999) [Pubmed]
  2. Studies on the basis for the toxicity of acrolein mercapturates. Ramu, K., Perry, C.S., Ahmed, T., Pakenham, G., Kehrer, J.P. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
  3. Human natural killer cell activity against porcine targets: modulation by control of the oxidation-reduction environment and role of adhesion molecule interactions. Horvath-Arcidiacono, J.A., Tsuyuki, S., Mostowski, H., Bloom, E.T. Cell. Immunol. (2003) [Pubmed]
  4. Chlorpyrifos resistance in mosquito Culex quinquefasciatus. Liu, H., Xu, Q., Zhang, L., Liu, N. J. Med. Entomol. (2005) [Pubmed]
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