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Chemical Compound Review:

AC1LCVRC diethyl (E)-but-2-enedioate

Synonyms: D95654_ALDRICH, AG-G-29076, ACN-S002054, HSDB 5722, NSC-20954, ...

Wang, F. et al., Ramu, K. et al., Horvath-Arcidiacono, J.A. et al., Liu, H. et al.

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Disease relevance of DIETHYL MALEATE

To assess the effects of redox stress on inflammatory responses in endotoxemia, mice were treated with either diethyl maleate (DEM), a glutathione-depleting agent, or buthionine sulfoximine (BSO), an inhibitor of glutathione synthesis, and challenged with LPS [1].
OxoPrGSH was toxic when present for 24 hr, and this toxicity was also enhanced by pretreatment with DEM [2].

High impact information on DIETHYL MALEATE

Hepatocyte iNOS induced by recombinant mouse TNF-alpha was also inhibited by DEM treatment [1].
By contrast, LPS-induced hepatocyte and hepatic sinusoidal endothelial cell iNOS expression was significantly inhibited in DEM-treated mice [1].
For fresh NK cells, pretreatment with diethyl maleate (DEM), which was used to deplete intracellular thiols, reduced lysis of porcine and human targets [3].
DEM treatment reduced the expression of CD11b and CD29 on fresh NK cells [3].
The expected enhancement of acrolein, oxoPrMCA, and oxoPrMCA S-oxide toxicity (assessed as cell proliferation by the alamarBlue assay) following a 2-hr exposure of cells treated with diethyl maleate (DEM) to deplete GSH was observed [2].

Chemical compound and disease context of DIETHYL MALEATE

Diethyl maleate (DEM) did not cause any significant change in the level of chlorpyrifos toxicity to HAmCq [4].

References

Redox imbalance differentially inhibits lipopolysaccharide-induced macrophage activation in the mouse liver. Wang, F., Wang, L.Y., Wright, D., Parmely, M.J. Infect. Immun. (1999) [Pubmed]
Studies on the basis for the toxicity of acrolein mercapturates. Ramu, K., Perry, C.S., Ahmed, T., Pakenham, G., Kehrer, J.P. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
Human natural killer cell activity against porcine targets: modulation by control of the oxidation-reduction environment and role of adhesion molecule interactions. Horvath-Arcidiacono, J.A., Tsuyuki, S., Mostowski, H., Bloom, E.T. Cell. Immunol. (2003) [Pubmed]
Chlorpyrifos resistance in mosquito Culex quinquefasciatus. Liu, H., Xu, Q., Zhang, L., Liu, N. J. Med. Entomol. (2005) [Pubmed]

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