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Chemical Compound Review

Resazoin     7-hydroxy-10-oxido- phenoxazin-3-one

Synonyms: RESAZURIN, Resazurine, Azoresorcin, AG-F-92288, SureCN1502340, ...
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Disease relevance of NSC10438

  • AMPA produced concentration-dependent toxicity detected by a decrease in fluorescence of the redox indicator Alamar blue and by an increase in lactic acid dehydrogenase release [1].
  • The microplate Alamar blue colorimetric method (breakpoint, 2.5 microg/ml) and the Mycobacterium Growth Indicator Tube (MGIT) system (breakpoint, 5.0 microg/ml) both produced 98.6% agreement when compared with the conventional proportion method performed on 7H10 agar using 5.0 microg of kanamycin/ml [2].
  • Microplate Alamar blue assay for Staphylococcus epidermidis biofilm susceptibility testing [3].
  • Antibody-mediated neutralization of pertussis toxin-induced proliferation of human peripheral blood mononuclear cells (PBMC) was assessed using alamarBlue and compared with results from the Chinese hamster ovary (CHO) cell assay using sera from vaccinated adults and convalescent children [4].
  • First, human pancreatic cancer cell (KP1-NL) growth assay was analyzed by Alamar Blue to determine the non-toxic concentration of MU derivatives, and the inhibitory effect on HA synthesis in the cell cultures was analyzed by HA measuring kit [5].

Psychiatry related information on NSC10438


High impact information on NSC10438


Chemical compound and disease context of NSC10438

  • Comparison of flow cytometric and Alamar Blue tests with the proportional method for testing susceptibility of Mycobacterium tuberculosis to rifampin and isoniazid [12].
  • Alamar blue fluorescence varied linearly with cell number and was decreased by treating cortical or cerebellar granule cell cultures with excitatory amino acids, exposing cortical cultures to hypoxia and glucose deprivation, or inducing apoptotic death in granule cell cultures by growth in medium containing a low concentration of K+ [13].
  • After 1 h hypoxia produced by Argon gas and 0, 2, 4, and 20 h reoxygenation the cell loss was calculated by propidiumiodide assay and the cell activity was investigated by Alamar Blue assay colorimetric measurement [14].
  • To study further the potential cell target of Listeria spp., the in-vitro entry of L. monocytogenes strains into intestinal cells was examined in relation to the metabolism, proliferation and differentiation of the cells by the alamarBlue assay, [3H] thymidine incorporation, and brush border-associated enzyme activities, respectively [15].
  • The aim of this study was to evaluate a simple method using a commercial colorimetric assay (Alamar Blue Oxidation-Reduction Indicator; Accumed, USA) in a microtiter format for testing the susceptibility of 94 strains of Mycobacterium tuberculosis to isoniazid, rifampicin, ethambutol and streptomycin [16].

Biological context of NSC10438

  • The ability of edaravone to reduce in vitro oxidative stress was investigated using cultured human renal tubular cells (HKC-8) and the cell viability assay with Alamar blue [17].
  • The format consists of three separate but compatible assays: the first quantitates the amount of cytotoxicity based upon the conversion of Alamar blue dye via cellular enzymes, while the second indirectly quantitates HCV replicon replication through measurement of the amount of NS3 protease activity present [18].
  • These DNAzymes were shown to markedly inhibit B95-8 cell growth compared with a disabled DNAzyme and untreated controls, as determined by an alamarBlue Assay. It was further demonstrated that these DNAzymes arrested the B95-8 cells in G0/G1 using flow cytometry [19].
  • In contrast to the MTT-assay, the Alamar Blue assay does not lead to cell death [20].
  • Hoechst 33342 staining was used to detect DNA fragmentation and Alamar blue was applied to measure oxide-reduction activity of cells [21].

Anatomical context of NSC10438


Associations of NSC10438 with other chemical compounds


Gene context of NSC10438


Analytical, diagnostic and therapeutic context of NSC10438


  1. A Bcl-2 antisense oligonucleotide increases alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) toxicity in cortical cultures. White, M.J., Chen, J., Zhu, L., Irvin, S., Sinor, A., DiCaprio, M.J., Jin, K., Greenberg, D.A. Ann. Neurol. (1997) [Pubmed]
  2. Kanamycin susceptibility testing of Mycobacterium tuberculosis using Mycobacterium Growth Indicator Tube and a colorimetric method. Bastian, I., Rigouts, L., Palomino, J.C., Portaels, F. Antimicrob. Agents Chemother. (2001) [Pubmed]
  3. Microplate Alamar blue assay for Staphylococcus epidermidis biofilm susceptibility testing. Pettit, R.K., Weber, C.A., Kean, M.J., Hoffmann, H., Pettit, G.R., Tan, R., Franks, K.S., Horton, M.L. Antimicrob. Agents Chemother. (2005) [Pubmed]
  4. Antibody-mediated neutralization of pertussis toxin-induced mitogenicity of human peripheral blood mononuclear cells. Millen, S.H., Bernstein, D.I., Connelly, B., Ward, J.I., Chang, S.J., Weiss, A.A. Infect. Immun. (2004) [Pubmed]
  5. Study of hyaluronan synthase inhibitor, 4-methylumbelliferone derivatives on human pancreatic cancer cell (KP1-NL). Morohashi, H., Kon, A., Nakai, M., Yamaguchi, M., Kakizaki, I., Yoshihara, S., Sasaki, M., Takagaki, K. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  6. Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem. Ramanathan, L., Gulyani, S., Nienhuis, R., Siegel, J.M. Neuroreport (2002) [Pubmed]
  7. Role of calcium in nitric oxide-mediated injury to rat gastric mucosal cells. Tripp, M.A., Tepperman, B.L. Gastroenterology (1996) [Pubmed]
  8. Reduced tumor necrosis factor signaling in primary human fibroblasts containing a tumor necrosis factor receptor superfamily 1A mutant. Siebert, S., Amos, N., Fielding, C.A., Wang, E.C., Aksentijevich, I., Williams, B.D., Brennan, P. Arthritis Rheum. (2005) [Pubmed]
  9. Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation. Amaar, Y.G., Baylink, D.J., Mohan, S. J. Bone Miner. Res. (2005) [Pubmed]
  10. Transient mismatch repair gene transfection for functional analysis of genetic hMLH1 and hMSH2 variants. Brieger, A., Trojan, J., Raedle, J., Plotz, G., Zeuzem, S. Gut (2002) [Pubmed]
  11. Rapid screening for high-titer retroviral packaging cell lines using an in situ fluorescence assay. Green, B.J., Rasko, J.E. Hum. Gene Ther. (2002) [Pubmed]
  12. Comparison of flow cytometric and Alamar Blue tests with the proportional method for testing susceptibility of Mycobacterium tuberculosis to rifampin and isoniazid. Reis, R.S., Neves, I., Lourenço, S.L., Fonseca, L.S., Lourenço, M.C. J. Clin. Microbiol. (2004) [Pubmed]
  13. Assessment of neuronal viability with Alamar blue in cortical and granule cell cultures. White, M.J., DiCaprio, M.J., Greenberg, D.A. J. Neurosci. Methods (1996) [Pubmed]
  14. Cytoprotective effect of two synthetic enhancer substances, (-)-BPAP and (-)-deprenyl, on human brain capillary endothelial cells and rat PC12 cells. Denes, L., Szilágyi, G., Gál, A., Bori, Z., Nagy, Z. Life Sci. (2006) [Pubmed]
  15. Cell proliferation enhances entry of Listeria monocytogenes into intestinal epithelial cells by two proliferation-dependent entry pathways. Velge, P., Bottreau, E., Van-Langendonck, N., Kaeffer, B. J. Med. Microbiol. (1997) [Pubmed]
  16. Simple procedure for drug susceptibility testing of Mycobacterium tuberculosis using a commercial colorimetic assay. Palomino, J.C., Portaels, F. Eur. J. Clin. Microbiol. Infect. Dis. (1999) [Pubmed]
  17. Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney. Doi, K., Suzuki, Y., Nakao, A., Fujita, T., Noiri, E. Kidney Int. (2004) [Pubmed]
  18. Development of a cell-based high-throughput specificity screen using a hepatitis C virus-bovine viral diarrhea virus dual replicon assay. O'Boyle, D.R., Nower, P.T., Lemm, J.A., Valera, L., Sun, J.H., Rigat, K., Colonno, R., Gao, M. Antimicrob. Agents Chemother. (2005) [Pubmed]
  19. Effect of EBV LMP1 targeted DNAzymes on cell proliferation and apoptosis. Lu, Z.X., Ye, M., Yan, G.R., Li, Q., Tang, M., Lee, L.M., Sun, L.Q., Cao, Y. Cancer Gene Ther. (2005) [Pubmed]
  20. Monitoring of cell viability and cell growth in a hollow-fiber bioreactor by use of the dye Alamar Blue. Gloeckner, H., Jonuleit, T., Lemke, H.D. J. Immunol. Methods (2001) [Pubmed]
  21. Cytotoxic effect of bone cements in HL-60 cells: distinction between apoptosis and necrosis. Ciapetti, G., Granchi, D., Cenni, E., Savarino, L., Cavedagna, D., Pizzoferrato, A. J. Biomed. Mater. Res. (2000) [Pubmed]
  22. A new, simple, nonradioactive, nontoxic in vitro assay to monitor corneal endothelial cell viability. Larson, E.M., Doughman, D.J., Gregerson, D.S., Obritsch, W.F. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  23. Resazurin reduction assay for ram sperm metabolic activity measured by spectrophotometry. Wang, S., Holyoak, G.R., Panter, K.E., Liu, Y., Evans, R.C., Bunch, T.D. Proc. Soc. Exp. Biol. Med. (1998) [Pubmed]
  24. A dye-based lymphocyte proliferation assay that permits multiple immunological analyses: mRNA, cytogenetic, apoptosis, and immunophenotyping studies. Zhi-Jun, Y., Sriranganathan, N., Vaught, T., Arastu, S.K., Ahmed, S.A. J. Immunol. Methods (1997) [Pubmed]
  25. Biomodulation of 5-fluorouracil by interferon-alpha in human renal carcinoma cells: relationship to the expression of thymidine phosphorylase. Morita, T., Tokue, A. Cancer Chemother. Pharmacol. (1999) [Pubmed]
  26. Developing macroporous bicontinuous materials as scaffolds for tissue engineering. Martina, M., Subramanyam, G., Weaver, J.C., Hutmacher, D.W., Morse, D.E., Valiyaveettil, S. Biomaterials (2005) [Pubmed]
  27. 1-methyl-4-phenylpyridinium (MPP+) decreases mitochondrial oxidation-reduction (REDOX) activity and membrane potential (Deltapsi(m)) in rat striatum. Nakai, M., Mori, A., Watanabe, A., Mitsumoto, Y. Exp. Neurol. (2003) [Pubmed]
  28. Colorimetric susceptibility testing for Aspergillus fumigatus: comparison of menadione-augmented 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide and Alamar blue tests. Jahn, B., Stüben, A., Bhakdi, S. J. Clin. Microbiol. (1996) [Pubmed]
  29. In vitro discrimination of fluoroquinolones toxicity on tendon cells: involvement of oxidative stress. Pouzaud, F., Bernard-Beaubois, K., Thevenin, M., Warnet, J.M., Hayem, G., Rat, P. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  30. Effect of MUC7 peptides on the growth of bacteria and on Streptococcus mutans biofilm. Wei, G.X., Campagna, A.N., Bobek, L.A. J. Antimicrob. Chemother. (2006) [Pubmed]
  31. Fluorometric assessment of In vitro antidermatophytic activities of antimycotics based on their keratin-penetrating power. Okeke, C.N., Tsuboi, R., Kawai, M., Ogawa, H. J. Clin. Microbiol. (2000) [Pubmed]
  32. The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis. Gilbert, L.C., Rubin, J., Nanes, M.S. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  33. Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli. Chen, X., Niyonsaba, F., Ushio, H., Okuda, D., Nagaoka, I., Ikeda, S., Okumura, K., Ogawa, H. J. Dermatol. Sci. (2005) [Pubmed]
  34. Apolipoprotein J inhibits the migration and adhesion of endothelial cells. Sivamurthy, N., Stone, D.H., LoGerfo, F.W., Quist, W.C. Surgery (2001) [Pubmed]
  35. Progesterone induces the proliferation of urothelial cells in an epidermal growth factor dependent manner. Teng, J., Wang, Z.Y., Bjorling, D.E. J. Urol. (2003) [Pubmed]
  36. Evaluation of the neurotoxic activity of typical and atypical neuroleptics: relevance to iatrogenic extrapyramidal symptoms. Gil-ad, I., Shtaif, B., Shiloh, R., Weizman, A. Cell. Mol. Neurobiol. (2001) [Pubmed]
  37. Human immunodeficiency virus type 1 infection of alveolar macrophages impairs their innate fungicidal activity. Ieong, M.H., Reardon, C.C., Levitz, S.M., Kornfeld, H. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  38. Association of albumin or protamine to lipoplexes: enhancement of transfection and resistance to serum. Faneca, H., Simões, S., Pedroso de Lima, M.C. The journal of gene medicine. (2004) [Pubmed]
  39. Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. Collins, L., Franzblau, S.G. Antimicrob. Agents Chemother. (1997) [Pubmed]
  40. Biodegradable polymer/hydroxyapatite composites: surface analysis and initial attachment of human osteoblasts. Rizzi, S.C., Heath, D.J., Coombes, A.G., Bock, N., Textor, M., Downes, S. J. Biomed. Mater. Res. (2001) [Pubmed]
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