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Chemical Compound Review

Resazoin     7-hydroxy-10-oxido- phenoxazin-3-one

Synonyms: RESAZURIN, Resazurine, Azoresorcin, AG-F-92288, SureCN1502340, ...
 
 
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Disease relevance of NSC10438

  • AMPA produced concentration-dependent toxicity detected by a decrease in fluorescence of the redox indicator Alamar blue and by an increase in lactic acid dehydrogenase release [1].
  • The microplate Alamar blue colorimetric method (breakpoint, 2.5 microg/ml) and the Mycobacterium Growth Indicator Tube (MGIT) system (breakpoint, 5.0 microg/ml) both produced 98.6% agreement when compared with the conventional proportion method performed on 7H10 agar using 5.0 microg of kanamycin/ml [2].
  • Microplate Alamar blue assay for Staphylococcus epidermidis biofilm susceptibility testing [3].
  • Antibody-mediated neutralization of pertussis toxin-induced proliferation of human peripheral blood mononuclear cells (PBMC) was assessed using alamarBlue and compared with results from the Chinese hamster ovary (CHO) cell assay using sera from vaccinated adults and convalescent children [4].
  • First, human pancreatic cancer cell (KP1-NL) growth assay was analyzed by Alamar Blue to determine the non-toxic concentration of MU derivatives, and the inhibitory effect on HA synthesis in the cell cultures was analyzed by HA measuring kit [5].
 

Psychiatry related information on NSC10438

 

High impact information on NSC10438

 

Chemical compound and disease context of NSC10438

  • Comparison of flow cytometric and Alamar Blue tests with the proportional method for testing susceptibility of Mycobacterium tuberculosis to rifampin and isoniazid [12].
  • Alamar blue fluorescence varied linearly with cell number and was decreased by treating cortical or cerebellar granule cell cultures with excitatory amino acids, exposing cortical cultures to hypoxia and glucose deprivation, or inducing apoptotic death in granule cell cultures by growth in medium containing a low concentration of K+ [13].
  • After 1 h hypoxia produced by Argon gas and 0, 2, 4, and 20 h reoxygenation the cell loss was calculated by propidiumiodide assay and the cell activity was investigated by Alamar Blue assay colorimetric measurement [14].
  • To study further the potential cell target of Listeria spp., the in-vitro entry of L. monocytogenes strains into intestinal cells was examined in relation to the metabolism, proliferation and differentiation of the cells by the alamarBlue assay, [3H] thymidine incorporation, and brush border-associated enzyme activities, respectively [15].
  • The aim of this study was to evaluate a simple method using a commercial colorimetric assay (Alamar Blue Oxidation-Reduction Indicator; Accumed, USA) in a microtiter format for testing the susceptibility of 94 strains of Mycobacterium tuberculosis to isoniazid, rifampicin, ethambutol and streptomycin [16].
 

Biological context of NSC10438

  • The ability of edaravone to reduce in vitro oxidative stress was investigated using cultured human renal tubular cells (HKC-8) and the cell viability assay with Alamar blue [17].
  • The format consists of three separate but compatible assays: the first quantitates the amount of cytotoxicity based upon the conversion of Alamar blue dye via cellular enzymes, while the second indirectly quantitates HCV replicon replication through measurement of the amount of NS3 protease activity present [18].
  • These DNAzymes were shown to markedly inhibit B95-8 cell growth compared with a disabled DNAzyme and untreated controls, as determined by an alamarBlue Assay. It was further demonstrated that these DNAzymes arrested the B95-8 cells in G0/G1 using flow cytometry [19].
  • In contrast to the MTT-assay, the Alamar Blue assay does not lead to cell death [20].
  • Hoechst 33342 staining was used to detect DNA fragmentation and Alamar blue was applied to measure oxide-reduction activity of cells [21].
 

Anatomical context of NSC10438

 

Associations of NSC10438 with other chemical compounds

 

Gene context of NSC10438

 

Analytical, diagnostic and therapeutic context of NSC10438

References

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