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Chemical Compound Review:

Arg-Trp (2R)-2-[[(2S)-2-amino-5...

Synonyms: AC1O52X4

Abdel-Rahman, S.Z. et al., Jakopitsch, C. et al., Endo, K. et al., Mutulis, F. et al., Sakane, N. et al., et al.

Stern, Siegmund, Corral, Haile,

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Disease relevance of Arg-Trp

The obesity index of subjects with the Arg/Arg or Arg/Trp genotype was significantly higher than that of those with the Trp/Trp genotype (8.2 +/- 18.7% vs 4.5 +/- 15.8%, P=0.04) [1].
Overall, the inheritance of 194Trp allele (Arg/Trp genotype) and 399Gln allele (combined Arg/Gln and Gln/Gln genotypes) was associated with increased colorectal cancer risk (odds ratio (OR)=2.56, 95% confidence limits (CL) 0.73-9.40, and P=0. 08 for 194Trp allele and OR=3.98, 95% CL 1.50-10.6, and P<0.001 for 399Gln allele) [2].

High impact information on Arg-Trp

The Arg/Arg or Arg/Trp genotype was significantly associated with PDR, compared with the Trp/Trp genotype, with an odds ratio of 2.55 (95% CI 1.25-5.16) [3].
We found no evidence of associations between the XRCC1 codon 194 Arg/Trp or Trp/Trp genotypes and the XRCC3 codon 241 Thr/Met or Met/Met genotypes [4].
KatGs, CCP and APXs contain identical amino acid triads in the heme pocket (distal Arg/Trp/His and proximal His/Trp/Asp), but differ dramatically in their reactivities towards hydrogen peroxide and various one-electron donors [5].
Thirty four N-alkylaminoacids (Arg, Trp, Nal, Pro, Hyp, L and D) and derivatives were prepared by a process that included reductive alkylation of the amino function [6].
Similar serotonin binding sites were found to exist on LHRH (Tyr Ser Trp) and MSH-ACTH tetrapeptide (Phe Arg Trp) [7].

References

Association of Trp64Arg polymorphism of the beta3-adrenergic receptor gene and no association of Gln223Arg polymorphism of the leptin receptor gene in Japanese schoolchildren with obesity. Endo, K., Yanagi, H., Hirano, C., Hamaguchi, H., Tsuchiya, S., Tomura, S. Int. J. Obes. Relat. Metab. Disord. (2000) [Pubmed]
Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt. Abdel-Rahman, S.Z., Soliman, A.S., Bondy, M.L., Omar, S., El-Badawy, S.A., Khaled, H.M., Seifeldin, I.A., Levin, B. Cancer Lett. (2000) [Pubmed]
Beta 3-adrenoreceptor gene polymorphism: a newly identified risk factor for proliferative retinopathy in NIDDM patients. Sakane, N., Yoshida, T., Yoshioka, K., Nakamura, Y., Umekawa, T., Kogure, A., Takakura, Y., Kondo, M. Diabetes (1997) [Pubmed]
XRCC1 and XRCC3 polymorphisms and their role as effect modifiers of unsaturated fatty acids and antioxidant intake on colorectal adenomas risk. Stern, M.C., Siegmund, K.D., Corral, R., Haile, R.W. Cancer Epidemiol. Biomarkers Prev. (2005) [Pubmed]
Engineering the proximal heme cavity of catalase-peroxidase. Jakopitsch, C., Regelsberger, G., Furtmüller, P.G., Rüker, F., Peschek, G.A., Obinger, C. J. Inorg. Biochem. (2002) [Pubmed]
N-alkylaminoacids and their derivatives interact with melanocortin receptors. Mutulis, F., Mutule, I., Wikberg, J.E. Bioorg. Med. Chem. Lett. (2002) [Pubmed]
Serotonin binding sites. I. Structures of sites on myelin basic protein, LHRH, MSH, ACTH, interferon, serum albumin, ovalbumin and red pigment concentrating hormone. Root-Bernstein, R.S., Westall, F.C. Brain Res. Bull. (1984) [Pubmed]

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