Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1O5MXH 4,5-bis(hydroxymethyl)-2- methyl-pyridin-3...

Synonyms:

Eskenazi, B. et al., Fleming, D.M. et al., David, T.J., McKinney, P.A. et al., Hughes, D.T. et al., et al.

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Disease relevance of Lenotan

Chromosomal studies on children with phocomelia, exposed to debendox during early pregnancy [1].
Bendectin (Debendox) as a risk factor for pyloric stenosis [2].
Debendox and birth defects [3].
Suitable alternatives to Debendox for morning sickness in pregnancy [4].

High impact information on Lenotan

Bendectin (Debendox) and congenital diaphragmatic hernia [5].
Bendectin (debendox) and congenital diaphragmatic hernia [6].
The maternal use of Bendectin (Debendox) in the first trimester of pregnancy was examined in a case-control (n = 1,427 and 3,001, respectively) study of malformed infants whose mothers were interviewed between 1974 and 1976 [2].
Debendox had been prescribed in one case of the Poland anomaly and in one case of isolated pectoralis absence, but in neither was the compound given during organogenesis [7].
During the first 13 weeks of gestation 620 of these women had been prescribed Debendox (dicyclomine-doxylamine-pyridoxine) and 743 other women agents other than Debendox containing pyridoxine [8].

Analytical, diagnostic and therapeutic context of Lenotan

Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC): childhood cancer and the consumption of debendox and related drugs in pregnancy [9].

References

Chromosomal studies on children with phocomelia, exposed to debendox during early pregnancy. Hughes, D.T., Cavanagh, N. Lancet (1983) [Pubmed]
Bendectin (Debendox) as a risk factor for pyloric stenosis. Eskenazi, B., Bracken, M.B. Am. J. Obstet. Gynecol. (1982) [Pubmed]
Debendox and birth defects. Hocking, B. Med. J. Aust. (1985) [Pubmed]
Suitable alternatives to Debendox for morning sickness in pregnancy. Crisafi, B., Bartlett, M. Australian family physician. (1985) [Pubmed]
Bendectin (Debendox) and congenital diaphragmatic hernia. Bracken, M.B., Berg, A. Lancet (1983) [Pubmed]
Bendectin (debendox) and congenital diaphragmatic hernia. Mitchell, A.A., Shapiro, S. Lancet (1983) [Pubmed]
Debendox does not cause the Poland anomaly. David, T.J. Arch. Dis. Child. (1982) [Pubmed]
Debendox in early pregnancy and fetal malformation. Fleming, D.M., Knox, J.D., Crombie, D.L. British medical journal (Clinical research ed.) (1981) [Pubmed]
Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC): childhood cancer and the consumption of debendox and related drugs in pregnancy. McKinney, P.A., Cartwright, R.A., Stiller, C.A., Hopton, P.A., Mann, J.R., Birch, J.M., Hartley, A.L., Waterhouse, J.A., Johnston, H.E. Br. J. Cancer (1985) [Pubmed]

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