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Chemical Compound Review

Diclegis     4,5-bis(hydroxymethyl)-2- methyl-pyridin-3...

Synonyms: Diclectin, AC1L4TES, LS-45739, Doxylamine / pyridoxine
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Disease relevance of Diclectin


High impact information on Diclectin


Biological context of Diclectin


Anatomical context of Diclectin


Associations of Diclectin with other chemical compounds


Gene context of Diclectin

  • Two of the three (microcephaly and cataract) had strong positive associations with vomiting in the absence of Bendectin use [16].

Analytical, diagnostic and therapeutic context of Diclectin

  • The objective of this study was to determine the incidence of adverse maternal and fetal effects and pregnancy outcome in 225 women taking Diclectin at the recommended (n = 123) or higher than recommended (n = 102) doses [4].
  • Therapeutic modalities discussed in this conference that have been used or are being tested are primarily symptomatic treatments (antihistamines, Bendectin (Merrell Dow; Cincinatti, Ohio), phenothiazines, hypnosis, accupressure, relaxation behavioral modification, audiogenic feedback training, newer medications, diet, and nutritional support) [13].
  • These are: unbridled discovery during litigation as exemplified by Bendectin, breast implants and cellular telephones; over zealous privacy laws; and the negative impact of managed care on epidemiologic research [17].
  • This meta-analysis provides an estimate of the relative risk of malformation at birth in association with Bendectin exposure [18].
  • The embryotoxic and teratogenic potential of Bendectin was assessed in this double-blind study in the cynomolgus monkey (Macaca fascicularis) [10].


  1. Congenital heart disease in relation to maternal use of Bendectin and other drugs in early pregnancy. Zierler, S., Rothman, K.J. N. Engl. J. Med. (1985) [Pubmed]
  2. Birth defects related to bendectin use in pregnancy. I. Oral clefts and cardiac defects. Mitchell, A.A., Rosenberg, L., Shapiro, S., Slone, D. JAMA (1981) [Pubmed]
  3. Pyloric stenosis and maternal Bendectin exposure. Aselton, P., Jick, H., Chentow, S.J., Perera, D.R., Hunter, J.R., Rothman, K.J. Am. J. Epidemiol. (1984) [Pubmed]
  4. The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy. Atanackovic, G., Navioz, Y., Moretti, M.E., Koren, G. Journal of clinical pharmacology. (2001) [Pubmed]
  5. Public health issues: bendectin, love canal. Paigen, B. Science (1981) [Pubmed]
  6. Is Bendectin a teratogen? Cordero, J.F., Oakley, G.P., Greenberg, F., James, L.M. JAMA (1981) [Pubmed]
  7. Risk assessment of drugs. Somers, E. Drug safety : an international journal of medical toxicology and drug experience. (1990) [Pubmed]
  8. Drugs and stillbirth. Porter, J.B., Hunter-Mitchell, J., Jick, H., Walker, A.M. American journal of public health. (1986) [Pubmed]
  9. Bendectin and fetal development. A study of Boston City Hospital. Morelock, S., Hingson, R., Kayne, H., Dooling, E., Zuckerman, B., Day, N., Alpert, J.J., Flowerdew, G. Am. J. Obstet. Gynecol. (1982) [Pubmed]
  10. Evaluation of bendectin embryotoxicity in nonhuman primates: II. Double-blind study in term cynomolgus monkeys. Hendrickx, A.G., Cukierski, M., Prahalada, S., Janos, G., Booher, S., Nyland, T. Teratology (1985) [Pubmed]
  11. Developmental toxicity evaluation of Bendectin in CD rats. Tyl, R.W., Price, C.J., Marr, M.C., Kimmel, C.A. Teratology (1988) [Pubmed]
  12. Pharmacokinetics of doxylamine given as Bendectin in the pregnant monkey and baboon. Rowland, J.M., Slikker, W., Holder, C.L., Denton, R., Prahalada, S., Young, J.F., Hendrickx, A.G. Reprod. Toxicol. (1989) [Pubmed]
  13. Medical, social, and legal implications of treating nausea and vomiting of pregnancy. Brent, R. Am. J. Obstet. Gynecol. (2002) [Pubmed]
  14. Bendectin (Debendox) as a risk factor for pyloric stenosis. Eskenazi, B., Bracken, M.B. Am. J. Obstet. Gynecol. (1982) [Pubmed]
  15. Are there teratogenic risks associated with antidotes used in the acute management of poisoned pregnant women? Bailey, B. Birth defects research. Part A, Clinical and molecular teratology. (2003) [Pubmed]
  16. Bendectin and human congenital malformations. Shiono, P.H., Klebanoff, M.A. Teratology (1989) [Pubmed]
  17. Alarums false, alarums real: challenges and threats to the future of epidemiology. Bracken, M.B. Annals of epidemiology. (1998) [Pubmed]
  18. Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies. McKeigue, P.M., Lamm, S.H., Linn, S., Kutcher, J.S. Teratology (1994) [Pubmed]
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