Disease relevance of Morning Sickness

• It was noted that PONV was more frequent among women who had significant morning sickness during early pregnancy and ondansetron was beneficial in reducing PONV in these women [1].
• Thalidomide, a drug originally used to treat morning sickness, was removed from the market place in the early 1960s after it was found to cause serious congenital birth defects [2].

High impact information on Morning Sickness

• It is suggested that morning sickness, resulting from secretion of hCG and thyroxine, reduces maternal energy intake [3].
• The increased free T4 and hCG and decreased TSH correlated with the severity of morning sickness, and these changes were especially marked in subjects with nausea and vomiting [4].
• Thalidomide caused severe malformations in babies born to mothers taking the drug for morning sickness in the late 1950s and early 1960s [5].
• Bendectin/diclectin for morning sickness: a Canadian follow-up of an American tragedy [6].
• There was no significant difference between the pregnancy histories of mothers of case children and those of mothers of control children in respect of reported frequency of morning sickness, the use of doxylamine/dicyclomine/pyridoxine, the date of commencement of its intake, the duration of intake, or its dose [7].

Chemical compound and disease context of Morning Sickness

• No relationship was found between these indicators of vitamin B6 status and the degree of morning sickness experienced by this group during early pregnancy [8].
• Suitable alternatives to Debendox for morning sickness in pregnancy [9].
• The most commonly cited herbs for morning sickness were ginger, chamomile, peppermint and raspberry leaf (55, 37, 44 and 63% cited respectively) [10].
• Thalidomide was first introduced to the market in Germany under the brand name of Contergan in 1956, as a non-barbiturate hypnotic, advocated to ensure a good nights sleep and to prevent morning sickness in pregnancy [11].
• There were no significant differences in plasma pyridoxal 5'-phosphate (PLP), erythrocyte aspartate aminotransferase (AspAT) activity, and stimulation of erythrocyte AspAT activity by exogenous PLP between subjects who experienced morning sickness and those who did not [8].

References