High impact information on Vacidin A

• The zwitterionic (amphotericin B, vacidin A) and negatively charged (N-N'-diacetyl vacidin) compounds induced permeability according to an all-or-none process on both cholesterol- and ergosterol-containing membranes [1].
• The ionophoric and hemolytic activities of two antifungal aromatic heptaenes: vacidin A and perimycin A, were studied on human red blood cells [2].
• The efficiency in inducing cation permeability of vacidin A, candicidin D and amphotericin B has been compared on small and large lipidic vesicles [3].
• Indeed the esterification or amidation of the carboxyl group of vacidin A or gedamycin eliminated the ability of the antibiotic to increase H+ conductance and consequently diminished their hemolytic activity to an important extent [4].

Anatomical context of Vacidin A

• The aromatic heptaene vacidin A induces ion selective channels in human red blood cells [5].

Associations of Vacidin A with other chemical compounds

• Cation permeability induced by two aromatic heptaenes, vacidin A and candicidin D on phospholipid unilamellar vesicles [6].

Analytical, diagnostic and therapeutic context of Vacidin A

• By combining permeability measurements (Gary-Bobo and Cybulska, J. Antibiotics 35, 1068 (1982)) and circular dichroism spectra, we found that for vacidin A, the same permeability inducing species is formed regardless of vesicles size [7].

References