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Chemical Compound Review

AC1O6FKD     (4E,6E,8E,10E,12E,14E,16E)- 18-(4-amino-3,5...

Synonyms:
 
 
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Disease relevance of CANDICIDIN

 

High impact information on CANDICIDIN

  • A phosphate control (PC) sequence, strikingly similar to the phosphate control (pho) boxes of many bacterial genes, has been isolated from the phosphate regulated promoter that controls biosynthesis of the antibiotic candicidin, and characterized [6].
  • The nucleotide (nt) sequence of the gene (pab) encoding p-aminobenzoic acid (PABA) synthase, a key enzyme in the biosynthesis of candicidin by Streptomyces griseus IMRU3570, was determined and an open reading frame (ORF) of 2171 nt was found [7].
  • The plasma membrane depolarized in a dose-dependent manner after candicidin (0.2-0.8 I.U./mL) [8].
  • Chronic provision of candicidin appeared to increase transit time through the gastrointestinal tract [9].
  • Within the limits of detection, oral candicidin did not appear to be absorbed from the intestine and appeared to be rapidly and quantitatively eliminated from the body in the feces [9].
 

Chemical compound and disease context of CANDICIDIN

 

Biological context of CANDICIDIN

  • Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex [1].
  • The released aromatic moiety of the heptaene polyenes aureofungin, candicidin, candimycin, hamycin and trichomycin was assayed after alkaline hydrolysis [14].
  • The modular architecture of the candicidin PKS and the availability of the PKSs involved in the biosynthesis of three polyene antibiotics (pimaricin, nystatin, and amphotericin B) shall make possible the creation of new, less toxic and more active polyene antibiotics through combinatorial biosynthesis and targeted mutagenesis [15].
  • Candicidin was capable of inducing marked DNA-synthesis and polyclonal antibody production when added to normal spleen cells [16].
 

Anatomical context of CANDICIDIN

 

Associations of CANDICIDIN with other chemical compounds

 

Gene context of CANDICIDIN

  • Prostatic HMG-CoA reductase levels were 3 times higher than those of the liver, but enzyme activity was unchanged by candicidin treatment [4].
  • Design and operating strategies for immobilized living cell reactor systems. Part I. Biosynthesis of candicidin [21].
 

Analytical, diagnostic and therapeutic context of CANDICIDIN

References

  1. Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex. Chen, S., Huang, X., Zhou, X., Bai, L., He, J., Jeong, K.J., Lee, S.Y., Deng, Z. Chem. Biol. (2003) [Pubmed]
  2. Candicidin in treatment of benign prostatic hypertrophy. Madsen, P.O., Dørflinger, T., Frimodt-Møller, P.C., Jensen, K.M. J. Urol. (1984) [Pubmed]
  3. Three genes hrdB, hrdD and hrdT of Streptomyces griseus IMRU 3570, encoding sigma factor-like proteins, are differentially expressed under specific nutritional conditions. Marcos, A.T., Gutiérrez, S., Díez, B., Fernández, F.J., Oguiza, J.A., Martín, J.F. Gene (1995) [Pubmed]
  4. Effect of candicidin on cholesterol and bile acid metabolism in the rat. Singhal, A.K., Mosbach, E.H., Schaffner, C.P. Lipids (1981) [Pubmed]
  5. Short-term topical treatment of vulvovaginal candidiasis with the combination of 5-fluorocytosine and candicidin. Kivinen, S., Tarkkila, T., Laakso, L., Laakso, K. Current medical research and opinion. (1979) [Pubmed]
  6. Phosphate control sequences involved in transcriptional regulation of antibiotic biosynthesis. Liras, P., Asturias, J.A., Martín, J.F. Trends Biotechnol. (1990) [Pubmed]
  7. The pab gene of Streptomyces griseus, encoding p-aminobenzoic acid synthase, is located between genes possibly involved in candicidin biosynthesis. Criado, L.M., Martín, J.F., Gil, J.A. Gene (1993) [Pubmed]
  8. Polyene antibiotics increase the ionic permeability of synaptosomal plasma membranes. Raatikainen, O., Kauppinen, R.A., Komulainen, H., Taipale, H., Pirttilä, T., Tuomisto, J. Biochem. Pharmacol. (1991) [Pubmed]
  9. The antihypercholesterolemic activity of candicdin as a function of dietary cholesterol in cockerels. Hausheer, W.C., Fisher, H. J. Nutr. (1978) [Pubmed]
  10. Effect of exogenous nucleotides on the candicidin fermentation. Martin, J.F., Demain, A.L. Can. J. Microbiol. (1977) [Pubmed]
  11. Specific inhibition of candicidin biosynthesis by the lipogenic inhibitor cerulenin. Martin, J.F., Mcdaniel, L.E. Biochim. Biophys. Acta (1975) [Pubmed]
  12. Effect of candicidin and colestipol on the testes and prostate glands of BIO 87.20 hamsters. Wang, G.M., Schaffner, C.P. Investigative urology. (1976) [Pubmed]
  13. Sequential expression of macromolecule biosynthesis and candicidin formation in Streptomyces griseus. Liras, P., Villanueva, J.R., Martín, J.F. J. Gen. Microbiol. (1977) [Pubmed]
  14. Identification of aromatic moieties and mycosamine in antifungal heptaenes with high-performance liquid chromatography, high-performance liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry. Raatikainen, O., Auriola, S., Tuomisto, J. J. Chromatogr. (1991) [Pubmed]
  15. Candicidin biosynthesis in Streptomyces griseus. Gil, J.A., Campelo-Diez, A.B. Appl. Microbiol. Biotechnol. (2003) [Pubmed]
  16. In vitro activating properties of polyene antibiotics for murine lymphocytes. Hammarström, L., Smith, C.I. Acta pathologica et microbiologica Scandinavica. Section C, Immunology. (1977) [Pubmed]
  17. Candicidin: physiologic effect on prostate. Sporer, A., Cohen, S., Kamat, M.H., Seebode, J.J. Urology (1975) [Pubmed]
  18. Cation permeability induced by two aromatic heptaenes, vacidin A and candicidin D on phospholipid unilamellar vesicles. Cybulska, B., Borowski, E., Prigent, Y., Gary-Bobo, C.M. J. Antibiot. (1981) [Pubmed]
  19. Polyene antibiotic biosynthesis gene clusters. Aparicio, J.F., Caffrey, P., Gil, J.A., Zotchev, S.B. Appl. Microbiol. Biotechnol. (2003) [Pubmed]
  20. The effect of some polyene macrolides on absorption from the small intestine in the rat. English, J., Chakraborty, J., Marks, V. J. Pharm. Pharmacol. (1976) [Pubmed]
  21. Design and operating strategies for immobilized living cell reactor systems. Part I. Biosynthesis of candicidin. Karkare, S.B., Venkatasubramanian, K., Vieth, W.R. Ann. N. Y. Acad. Sci. (1986) [Pubmed]
  22. Comparison of candicidin, levorin and trichomycin by means of high-performance liquid chromatography. Hansen, S.H., Thomsen, M. J. Chromatogr. (1976) [Pubmed]
 
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