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Chemical Compound Review

depudecin     (1R)-1-[(2S,3S)-3-[(E)-2- [(3S)-3-(1...

Synonyms: AC1O5Q7V, CBChromo1_000044
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Disease relevance of depudecin


High impact information on depudecin


Anatomical context of depudecin

  • These results suggest that depudecin could be promising as an anti-angiogenic agent and that its anti-angiogenic action involves an inhibitory effect on vascular endothelial cell growth [5].

Associations of depudecin with other chemical compounds

  • Acid/urea/Triton gel electrophoresis analysis show anti-parasitic activity of depudecin appears to be due to the inhibition of protozoal histone deacetylase, which induces hyperacetylation of histones in N. caninum [6].

Gene context of depudecin


  1. Synthesis and cellular characterization of the detransformation agent, (-)-depudecin. Shimada, J., Kwon, H.J., Sawamura, M., Schreiber, S.L. Chem. Biol. (1995) [Pubmed]
  2. Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase. Kwon, H.J., Owa, T., Hassig, C.A., Shimada, J., Schreiber, S.L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Inhibition of angiogenesis by rhizoxin, a microbial metabolite containing two epoxide groups. Onozawa, C., Shimamura, M., Iwasaki, S., Oikawa, T. Jpn. J. Cancer Res. (1997) [Pubmed]
  4. A novel compound, depudecin, induces production of transformation to the flat phenotype of NIH3T3 cells transformed by ras-oncogene. Sugita, K., Yoshida, H., Matsumoto, M., Matsutani, S. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  5. Depudecin, a microbial metabolite containing two epoxide groups, exhibits anti-angiogenic activity in vivo. Oikawa, T., Onozawa, C., Inose, M., Sasaki, M. Biol. Pharm. Bull. (1995) [Pubmed]
  6. Anti-parasitic activity of depudecin on Neospora caninum via the inhibition of histone deacetylase. Kwon, H.J., Kim, J.H., Kim, M., Lee, J.K., Hwang, W.S., Kim, D.Y. Vet. Parasitol. (2003) [Pubmed]
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