Disease relevance of Cprg-hcl

• Synergistic effects induced by cycloprodigiosin hydrochloride and epirubicin on human breast cancer cells [1].
• Recently, we reported that cycloprodigiosin hydrochloride (cPrG.HCl), a novel H+/Cl- symporter, induces acidification of the cytosol and leads to apoptosis on rat and human liver cancer cells [2].

High impact information on Cprg-hcl

• Cycloprodigiosin hydrocloride suppresses tumor necrosis factor (TNF) alpha-induced transcriptional activation by NF-kappaB [3].
• These results indicate that cycloprodigiosin up-regulates the induction of iNOS by increasing NF-kappaB activation, at least partly through enhancement of type 1 interleukin-1 receptor expression [4].
• Cycloprodigiosin is an anticancer drug that induces apoptosis through NF-kappaB-dependent mechanisms [4].
• Cycloprodigiosin alone had no effect on NO production by primary cultured rat hepatocytes [4].
• Consistent with this observation, cycloprodigiosin promoted the translocation of p65 (a subunit of NF-kappaB) to the nucleus [4].

Biological context of Cprg-hcl

• Cycloprodigiosin up-regulates inducible nitric oxide synthase gene expression in hepatocytes stimulated by interleukin-1beta [4].

Anatomical context of Cprg-hcl

• Induction of apoptosis of activated murine splenic T cells by cycloprodigiosin hydrochloride, a novel immunosuppressant [5].
• Applying vacuole-perfusion and plasma membrane permeabilization techniques to internodal cells of Chara, we analyzed the requirement of Cl- for the action of cycloprodigiosin (cPrG) to inhibit vacuole acidification in situ [6].

Gene context of Cprg-hcl

• Cycloprodigiosin had no effect on degradation of the inhibitory subunit of NF-kappaB (IkappaBalpha), but lessened the recovery of IkappaBalpha levels [4].

Analytical, diagnostic and therapeutic context of Cprg-hcl

• The electrophoretic mobility shift assay revealed that cycloprodigiosin caused an increase of NF-kappaB activation [4].

References