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Chemical Compound Review

Cprg-hcl     3-[(E)-[(5Z)-3-methoxy-5- pyrrol-2-ylidene...

Synonyms: AC1O5SFD, 86797-91-3, Cycloprodigiosin, Cycloprodigiosin hydrochloride
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Disease relevance of Cprg-hcl


High impact information on Cprg-hcl


Biological context of Cprg-hcl


Anatomical context of Cprg-hcl


Gene context of Cprg-hcl

  • Cycloprodigiosin had no effect on degradation of the inhibitory subunit of NF-kappaB (IkappaBalpha), but lessened the recovery of IkappaBalpha levels [4].

Analytical, diagnostic and therapeutic context of Cprg-hcl


  1. Synergistic effects induced by cycloprodigiosin hydrochloride and epirubicin on human breast cancer cells. Yamamoto, D., Tanaka, K., Nakai, K., Baden, T., Inoue, K., Yamamoto, C., Takemoto, H., Kamato, K., Hirata, H., Morikawa, S., Inubushi, T., Hioki, K. Breast Cancer Res. Treat. (2002) [Pubmed]
  2. Cycloprodigiosin hydrochloride, a H+/Cl- symporter, induces apoptosis in human colon cancer cell lines in vitro. Yamamoto, C., Takemoto, H., Kuno, K., Yamamoto, D., Nakai, K., Baden, T., Kamata, K., Hirata, H., Watanabe, T., Inoue, K. Oncol. Rep. (2001) [Pubmed]
  3. Cycloprodigiosin hydrocloride suppresses tumor necrosis factor (TNF) alpha-induced transcriptional activation by NF-kappaB. Kamata, K., Okamoto, S., Oka, S., Kamata, H., Yagisawa, H., Hirata, H. FEBS Lett. (2001) [Pubmed]
  4. Cycloprodigiosin up-regulates inducible nitric oxide synthase gene expression in hepatocytes stimulated by interleukin-1beta. Teshima, S., Nakanishi, H., Kamata, K., Kaibori, M., Kwon, A.H., Kamiyama, Y., Nishizawa, M., Ito, S., Okumura, T. Nitric Oxide (2004) [Pubmed]
  5. Induction of apoptosis of activated murine splenic T cells by cycloprodigiosin hydrochloride, a novel immunosuppressant. Azuma, T., Watanabe, N., Yagisawa, H., Hirata, H., Iwamura, M., Kobayashi, Y. Immunopharmacology (2000) [Pubmed]
  6. Demonstration of Cl- requirement for inhibition of vacuolar acidification by cycloprodigiosin in situ. Nakayasu, T., Kawauchi, K., Hirata, H., Shimmen, T. Plant Cell Physiol. (2000) [Pubmed]
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