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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Hoe-892     methyl4-[[(1R,5S,7R,8S)-7- hydroxy-8-[(E...

Synonyms: Hoe 892, AC1O5YLY, S 79 2892 A, 75111-35-2, beta-Thia-imino-prostacyclin
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Disease relevance of beta-Thia-imino-prostacyclin


High impact information on beta-Thia-imino-prostacyclin

  • Both PGI2 and Hoe 892 given subcutaneously (s.c.) reduced dose-dependent gastric acid secretion, the ID50 (dose producing 50% inhibition) being about 48.6 and 11.8 micrograms/kg, respectively [1].
  • Short- or long-term treatment with PGI2 or its stable analogue (Hoe 892), injected in doses causing about 50% inhibition of acid secretion and significant increments in serum gastrin levels, failed to affect any of the growth-related parameters in the stomach, duodenum, or pancreas [3].
  • Hoe 892 stimulated renin release in anesthetized rats [2].
  • Single oral administration of Hoe 892 in conscious rabbits inhibited platelet aggregation for more than 3 hrs with an ID50 of 0.2 mg/kg using collagen and 1.5 mg/kg using AA [2].


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