Disease relevance of NSC672222

• Toxicity to Artemia salina larvae within most species was correlated with the concentration of either beauvericin or fusaproliferin produced [1].

High impact information on NSC672222

• Fusaproliferin was also toxic to the human nonneoplastic B-lymphocyte cell line IARC/LCL 171 (50% cytotoxic concentration, approximately 55 microM in culture in stationary phase after a 48-h exposure) [2].
• Hexane partitioning was effective in removing many impurities from the crude fusaproliferin extracts prior to the liquid chromatography step [3].
• Interaction of fusarium mycotoxins, fusaproliferin and fumonisin B1, with DNA studied by electrospray ionization mass spectrometry [4].
• These findings can be of use in the understanding of molecular mechanisms of action during apoptosis and can be correlated with the teratogenic effect of fusaproliferin [4].
• Using mild experimental ESI conditions specific noncovalent interactions were detected between both single- and double-stranded model oligonucleotides and fusaproliferin with 1:1 stoichiometry [4].

Biological context of NSC672222

• The kinetics of the production of fusaproliferin by Fusarium subglutinans ITEM 2404 in maize and rice cultures was investigated at various incubation temperatures [5].

Associations of NSC672222 with other chemical compounds

• Production of beauvericin, moniliformin, fusaproliferin, and fumonisins b(1), b(2), and b(3) by fifteen ex-type strains of fusarium species [6].

References