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Chemical Compound Review

Litoxetina     4-(naphthalen-2- ylmethoxy)piperidine

Synonyms: Litoxetine, Litoxetinum, CHEMBL471036, SureCN119884, AG-H-49990, ...
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Psychiatry related information on Litoxetine

  • 4. Overall, there were few changes in any of the psychometric tests and although the higher doses of litoxetine improved CFF, these effects were weak in that differences could only be detected when the results were pooled against time [1].

High impact information on Litoxetine


Anatomical context of Litoxetine


Associations of Litoxetine with other chemical compounds

  • However, in tissues from pCPA treated animals GR 125487 (10 nM) exerted a slight but significant antagonism of litoxetine response (P = 0.037: ANOVA for continuous-by-class effects) mainly involving the high potency phase [6].

Analytical, diagnostic and therapeutic context of Litoxetine

  • EEG profile of litoxetine after single and repeated administration in healthy volunteers [3].


  1. The psychomotor and cognitive effects of litoxetine in young and middle aged volunteers. Fairweather, D.B., Patat, A., Rosenzweig, P., Curson, V.H., Dunmore, C., Dubruc, C., Hindmarch, I. British journal of clinical pharmacology. (1995) [Pubmed]
  2. The interaction of antidepressant drugs with central and peripheral (enteric) 5-HT3 and 5-HT4 receptors. Lucchelli, A., Santagostino-Barbone, M.G., Barbieri, A., Candura, S.M., Tonini, M. Br. J. Pharmacol. (1995) [Pubmed]
  3. EEG profile of litoxetine after single and repeated administration in healthy volunteers. Patat, A., Trocherie, S., Thébault, J.J., Rosenzweig, P., Dubruc, C., Bianchetti, G., Morselli, P.L., Court, L.A. British journal of clinical pharmacology. (1994) [Pubmed]
  4. Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties. Angel, I., Schoemaker, H., Prouteau, M., Garreau, M., Langer, S.Z. Eur. J. Pharmacol. (1993) [Pubmed]
  5. Induction of hyperlocomotion in mice exposed to a novel environment by inhibition of serotonin reuptake. A pharmacological characterization of diverse classes of antidepressant agents. Brocco, M., Dekeyne, A., Veiga, S., Girardon, S., Millan, M.J. Pharmacol. Biochem. Behav. (2002) [Pubmed]
  6. Influence of fluoxetine and litoxetine on 5-HT4 receptor-mediated relaxation in the rat isolated oesophagus. Lucchelli, A., Santagostino-Barbone, M.G., Masoero, E., Baiardi, P., Tonini, M. Fundamental & clinical pharmacology. (1999) [Pubmed]
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