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Chemical Compound Review:

Litoxetina 4-(naphthalen-2- ylmethoxy)piperidine

Synonyms: Litoxetine, Litoxetinum, CHEMBL471036, SureCN119884, AG-H-49990, ...

Patat, A. et al., Lucchelli, A. et al., Fairweather, D.B. et al., Angel, I. et al., Brocco, M. et al., et al.

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Psychiatry related information on Litoxetine

4. Overall, there were few changes in any of the psychometric tests and although the higher doses of litoxetine improved CFF, these effects were weak in that differences could only be detected when the results were pooled against time [1].

High impact information on Litoxetine

Litoxetine had an IC50 of 0.3 microM [2].
The aim was to assess the EEG profile of litoxetine in parallel with its pharmacokinetics after a single dose or multiple administrations for 4 days (6 doses) of two dosages (10 mg and 25 mg) [3].
3. In single or multiple doses, litoxetine induced EEG changes characterised by a dose-related increase in fast beta energies, mainly beta 2, without any changes in slow waves (delta and theta) [3].
The possibility that the antiemetic effects of litoxetine may be mediated through an interaction with 5HT3 receptors was studied using [3H]quipazine or [3H]BRL 43694 to label the 5HT3 receptor [4].
The selective serotonin (5-HT) reuptake inhibitors (SSRIs), citalopram, fluoxetine, paroxetine, fluvoxamine, litoxetine and zimelidine, dose-dependently enhanced LA [5].

Anatomical context of Litoxetine

The influence of two selective serotonin reuptake inhibitors (SSRIs), litoxetine and fluoxetine, has been studied on 5-HT4 receptor-mediated relaxation in the rat isolated oesophageal muscularis mucosae [6].

Associations of Litoxetine with other chemical compounds

However, in tissues from pCPA treated animals GR 125487 (10 nM) exerted a slight but significant antagonism of litoxetine response (P = 0.037: ANOVA for continuous-by-class effects) mainly involving the high potency phase [6].

Analytical, diagnostic and therapeutic context of Litoxetine

EEG profile of litoxetine after single and repeated administration in healthy volunteers [3].

References

The psychomotor and cognitive effects of litoxetine in young and middle aged volunteers. Fairweather, D.B., Patat, A., Rosenzweig, P., Curson, V.H., Dunmore, C., Dubruc, C., Hindmarch, I. British journal of clinical pharmacology. (1995) [Pubmed]
The interaction of antidepressant drugs with central and peripheral (enteric) 5-HT3 and 5-HT4 receptors. Lucchelli, A., Santagostino-Barbone, M.G., Barbieri, A., Candura, S.M., Tonini, M. Br. J. Pharmacol. (1995) [Pubmed]
EEG profile of litoxetine after single and repeated administration in healthy volunteers. Patat, A., Trocherie, S., Thébault, J.J., Rosenzweig, P., Dubruc, C., Bianchetti, G., Morselli, P.L., Court, L.A. British journal of clinical pharmacology. (1994) [Pubmed]
Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties. Angel, I., Schoemaker, H., Prouteau, M., Garreau, M., Langer, S.Z. Eur. J. Pharmacol. (1993) [Pubmed]
Induction of hyperlocomotion in mice exposed to a novel environment by inhibition of serotonin reuptake. A pharmacological characterization of diverse classes of antidepressant agents. Brocco, M., Dekeyne, A., Veiga, S., Girardon, S., Millan, M.J. Pharmacol. Biochem. Behav. (2002) [Pubmed]
Influence of fluoxetine and litoxetine on 5-HT4 receptor-mediated relaxation in the rat isolated oesophagus. Lucchelli, A., Santagostino-Barbone, M.G., Masoero, E., Baiardi, P., Tonini, M. Fundamental & clinical pharmacology. (1999) [Pubmed]

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